Actively Recruiting
A Study to Test the Benefit of Vitamin B5 in Patients With Melanoma
Led by University Health Network, Toronto · Updated on 2025-07-14
12
Participants Needed
1
Research Sites
109 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is open to patients with a type of cancer called melanoma. Patients can join the study if their tumor cannot be removed by surgery or has spread to other organs, and are planned to receive immunotherapy as treatment for their cancer. This study is looking at whether taking calcium pantothenate supplement (a type of Vitamin B5) can increase its levels in the blood and have an effect in the immune system, when its used in combination with the immunotherapy.
CONDITIONS
Official Title
A Study to Test the Benefit of Vitamin B5 in Patients With Melanoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed written and voluntary informed consent.
- Age 18 years or older, male or female.
- Histologically or cytologically confirmed unresectable stage III or stage IV metastatic melanoma (AJCC 8th edition).
- No prior systemic treatment for advanced melanoma including chemotherapy, immunotherapy, or targeted therapy.
- Willing and able to provide stool and blood samples at specified times.
- Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.
- Females of childbearing potential must have a negative pregnancy test within 72 hours before study start.
You will not qualify if you...
- Unable to swallow oral medications or have gastrointestinal disorders interfering with absorption (e.g., bowel obstruction, short gut syndrome, blind loop syndrome, ileostomy), though colostomy patients may enroll.
- Diagnosis of inflammatory bowel disease.
- Any condition that could affect safety or study results at the investigator's discretion.
- Pregnant or planning pregnancy within 6 months.
- Breastfeeding female patients.
- Allergy to calcium pantothenate, Nivolumab, Ipilimumab, or their non-medicinal ingredients.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Health Network- Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
Research Team
M
Minge Xu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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