Brillouin microscopy of collagen crosslinking: noncontact depth-dependent analysis of corneal elastic modulus.
Giuliano Scarcelli, Sabine Kling, Elena Quijano...
https://pubmed.ncbi.nlm.nih.gov/23361513Actively Recruiting
Age: 20Years - 75Years
All Genders
Healthy Volunteers
ID02118922
A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia
Led by Massachusetts General Hospital · Updated on 2025-11-06
168
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
M
Massachusetts General Hospital
Lead Sponsor
H
Harvard Medical School (HMS and HSDM)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the potential of a new technique called Brillouin microscopy to diagnose corneal conditions such as keratoconus and ectasia. The study compares the biomechanical properties of corneas in people with keratoconus, those with post-LASIK ectasia, and individuals with normal corneas. This observational study aims to better understand differences in corneal tissue using this advanced imaging method. Participants include volunteers with normal corneas, patients diagnosed with various stages of keratoconus, individuals who had LASIK surgery with or without complications, people scheduled for PRK or LASIK surgery, and patients with Fuch's endothelial corneal dystrophy. The study involves axial scans of the cornea using Brillouin imaging to assess and compare corneal biomechanics across these groups. Specific inclusion and exclusion criteria apply to each group based on diagnosis, prior surgeries, and other eye health factors. During the study, participants undergo corneal imaging to measure the cornea's elastic modulus, reflecting its biomechanical properties. Researchers monitor these properties over time to evaluate the diagnostic capabilities of Brillouin microscopy. Participants will be assessed for corneal health through topography, pachymetry, and clinical evaluations, with the study lasting several years to gather comprehensive data. The research team also excludes individuals unable to understand imaging instructions or with certain eye conditions to ensure accurate measurements.
CONDITIONS
Brief Title
A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia
Who Can Participate
Age: 20Years - 75Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Adults aged 20 to 75 years
- Healthy subjects with normal corneas, normal topography, and pachymetry
- Patients diagnosed with mild, moderate, or advanced keratoconus based on expert evaluation
- Healthy subjects who had LASIK surgery in the past 12 months without complications, with normal post-operative topography and pachymetry
- Patients aged 20 to 60 diagnosed with post-LASIK ectasia at least 12 months after surgery based on clinical evaluation
- Patients diagnosed with myopia scheduled for PRK surgery, excluding those with high astigmatism > 2 diopters or prior ocular surgeries
- Patients diagnosed with myopia scheduled for LASIK surgery, excluding those with high astigmatism > 2 diopters or prior ocular surgeries
- Patients diagnosed with Fuch's endothelial corneal dystrophy at early, mild, or advanced stages, including those with or without keratoconus, excluding other corneal disorders or history of surgeries affecting endothelial cells
You will not qualify if you...
- Volunteers with occludable narrow angles without a patent peripheral iridotomy
- Monocular subjects
- Individuals who do not or cannot understand instructions for the imaging
- Patients with high astigmatism greater than 2 diopters in PRK or LASIK groups
- Patients with prior ocular surgeries other than specified LASIK or PRK
- Patients taking ocular medications other than seasonal allergy medicines such as ketotifen or artificial tears
- Patients with corneal disorders other than keratoconus or Fuch's dystrophy or history of surgeries affecting corneal endothelium, such as cataract surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Up to 1 day
Participants undergo Brillouin imaging to assess the corneal properties related to ectasia and other corneal conditions.
1 visit (in-person)
Long-term Monitoring
Duration - Up to 10 years
Participants may be observed over time to monitor changes in corneal properties and disease progression.
Follow-up visits as scheduled depending on participant group
Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
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Research Team
F
Fatima Clouser, MS
A
Andy Yun, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
7
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Published Research Related To This Trial
In vivo Brillouin optical microscopy of the human eye.
Giuliano Scarcelli, Seok Hyun Yun
https://pubmed.ncbi.nlm.nih.gov/22513631Brillouin optical microscopy for corneal biomechanics.
Giuliano Scarcelli, Roberto Pineda, Seok Hyun Yun
https://pubmed.ncbi.nlm.nih.gov/22159012Confocal Brillouin microscopy for three-dimensional mechanical imaging.
Giuliano Scarcelli, Seok Hyun Yun
https://pubmed.ncbi.nlm.nih.gov/19812712