Actively Recruiting
A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia
Led by Massachusetts General Hospital · Updated on 2025-11-06
168
Participants Needed
1
Research Sites
691 weeks
Total Duration
On this page
Sponsors
M
Massachusetts General Hospital
Lead Sponsor
H
Harvard Medical School (HMS and HSDM)
Collaborating Sponsor
AI-Summary
What this Trial Is About
We have developed novel Brillouin microscopy and we are testing its potential for keratoconus and ectasia diagnostics. We plan to perform axial scans of the cornea in human volunteers in order to compare biomechanical properties of Keratoconus vs. Normal corneas and compare biomechanical properties of post-LASIK ectasia vs. normal corneas.
CONDITIONS
Official Title
A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy subjects with normal corneas, topography, and pachymetry
- Patients diagnosed with mild, moderate, or advanced keratoconus based on topography and pachymetry
- Healthy subjects who underwent uncomplicated LASIK surgery within the past 12 months with normal post-operative topography and pachymetry
- Patients aged 20 to 60 years with post-LASIK ectasia diagnosed by topography, pachymetry, and clinical evaluation at least 12 months after LASIK
- Patients diagnosed with myopia scheduled for PRK surgery without high astigmatism (> 2 diopters) or prior ocular surgeries
- Myopic patients scheduled to receive LASIK surgery without high astigmatism (> 2 diopters) or prior ocular surgeries
- Patients diagnosed with early, mild, or advanced stages of Fuchs' Endothelial Corneal Dystrophy, including those with or without keratoconus
You will not qualify if you...
- Patients with high astigmatism greater than 2 diopters
- Patients with prior ocular surgeries other than those specified
- Patients taking ocular medications except seasonal allergy medicine like ketotifen or artificial tears
- Patients with occludable narrow angles without a patent peripheral iridotomy
- Monocular subjects
- Subjects unable to understand instructions for imaging procedures
- Patients with corneal disorders other than keratoconus or Fuchs' dystrophy
- Patients with history of ophthalmological surgeries that affect endothelial cell status, such as cataract surgeries
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
F
Fatima Clouser, MS
CONTACT
A
Andy Yun, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
7
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