Actively Recruiting

Phase 4
Age: 55Years +
All Genders
NCT07220538

A Study Testing How Well the Drug Extract of Ginkgo Biloba Leaves Tablets Works for People With Memory or Thinking Problems After a Stroke When Added to Standard Treatment

Led by Dr. Willmar Schwabe GmbH & Co. KG · Updated on 2026-04-23

400

Participants Needed

30

Research Sites

109 weeks

Total Duration

On this page

Sponsors

D

Dr. Willmar Schwabe GmbH & Co. KG

Lead Sponsor

B

Beijing Tiantan Hospital

Collaborating Sponsor

AI-Summary

What this Trial Is About

The goal of this clinical trial is to learn if Extract of Ginkgo Biloba Leaves Tablets help improve thinking and memory in people aged 55 years and older who had an ischemic stroke (a type of stroke caused by a blocked blood vessel in the brain). It will also look at how safe the Extract of Ginkgo Biloba Leaves Tablets are. The main questions it aims to answer are: * Do the Extract of Ginkgo Biloba Leaves Tablets help people with memory or thinking problems after an ischemic stroke? * What medical problems do people have when taking the Extract of Ginkgo Biloba Leaves Tablets ? Researchers will compare people who take the Extract of Ginkgo Biloba Leaves Tablets along with their usual post-stroke treatment to people who only receive their usual post-stroke treatment. Participants will: * Have had an ischemic stroke confirmed by MRI (Magnet Resonance Imaging, a magnetic scan that helps seeing inside the body in great detail) 7 to 14 days before joining the study * Take Extract of Ginkgo Biloba Leaves Tablets (240 mg per day) in addition to usual post-stroke treatment for 12 months, or receive only usual post-stroke treatment for 12 months * Be treated initially at hospitals across China * Visit the clinic 4, 26, and 52 weeks following the baseline for checkups and tests, and receive follow-up calls after 12 and 38 weeks.

CONDITIONS

Official Title

A Study Testing How Well the Drug Extract of Ginkgo Biloba Leaves Tablets Works for People With Memory or Thinking Problems After a Stroke When Added to Standard Treatment

Who Can Participate

Age: 55Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Male and female participants aged 55 years or older who gave informed consent
  • Non-disabling acute ischemic stroke confirmed by MRI, with NIHSS score 5 or less and mRS score 2 or less at screening
  • Cognitive impairment shown by Montreal Cognitive Assessment score below 23 for up to 12 years of education or below 22 for more than 12 years of education
  • Sufficient Chinese language skills to understand questions, complete questionnaires, and undergo neuropsychological testing
Not Eligible

You will not qualify if you...

  • Participation in another experimental drug trial currently or within 4 weeks before enrollment
  • Severe speech, movement, vision, hearing, or language difficulties that prevent cooperation or test performance
  • Pre-stroke cognitive impairment or major neurocognitive disorders such as dementia
  • Cardiogenic ischemic stroke, atrial fibrillation, or conditions requiring anticoagulants
  • Need for thrombolytic treatment at screening or first visit
  • Stroke with hemorrhagic transformation
  • Use of traditional Chinese medicines
  • Major neurological disorders including brain tumors, Parkinson's disease, epilepsy, and others
  • Major depression or generalized anxiety disorder
  • Active malignant disease
  • Alcohol addiction or substance abuse
  • Known allergy to Ginkgo biloba or ingredients of the study drug
  • Inability to attend scheduled follow-ups due to hospitalization or nursing care
  • Severe comorbid conditions with life expectancy under 12 months

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 30 locations

1

The People's Hospital of Anyang City

Anyang, China

Actively Recruiting

2

Baotou Central Hospital

Baotou, China

Actively Recruiting

3

Tiantan Hospital

Beijing, China

Actively Recruiting

4

Beipiao Central Hospital

Beipiao, China

Actively Recruiting

5

Benxi Central Hospital

Benxi, China

Actively Recruiting

6

The First People's Hospital of Chenzhou

Chenzhou, China

Actively Recruiting

7

Affiliated Hospital of Chifeng University

Chifeng, China

Active, Not Recruiting

8

Dalian Lvshunkou District Traditional Chinese Medicine Hospital

Dalian, China

Actively Recruiting

9

Dalian University Affiliated Xinhua Hospital

Dalian, China

Actively Recruiting

10

Affiliated Hospital of Hebei University

Hebei, China

Actively Recruiting

11

The Second Hospital of Hebei Medical University

Hebei, China

Actively Recruiting

12

The Second Affiliated Hospital of Henan University of Science and Technology

Henan, China

Actively Recruiting

13

The First Affiliated Hospital of Jiamusi University

Jiamusi, China

Actively Recruiting

14

Liaocheng People´s Hospital

Liaocheng, China

Actively Recruiting

15

Liuzhou Workers´ Hospital

Liuzhou, China

Actively Recruiting

16

Luoyang Central Hospital

Luoyang, China

Actively Recruiting

17

Puyang Oilfield General Hospital

Pujiang, China

Actively Recruiting

18

Qilu Hospital of Shandong University

Qingdao, China

Actively Recruiting

19

First Hospital of Shanxi Medical University

Shanxi, China

Active, Not Recruiting

20

Second Hospital of Shanxi Medical University

Shanxi, China

Actively Recruiting

21

Shanxi Cardiovascular Hospital

Shanxi, China

Actively Recruiting

22

The First People's Hospital Of Shenyang

Shenyang, China

Actively Recruiting

23

Siping City Central People's Hospital

Siping, China

Actively Recruiting

24

Suining Central Hospital

Suining, China

Actively Recruiting

25

Weifang People´s Hospiztal

Weifang, China

Actively Recruiting

26

Zhongnan Hospital of Wuhan University

Wuhan, China

Active, Not Recruiting

27

Wuxi No.2 People's Hospital

Wuxi, China

Actively Recruiting

28

Yantaishan Hospital

Yantai, China

Actively Recruiting

29

Zhumadian Central Hospital

Zhumadian, China

Actively Recruiting

30

Zibo Municipal Hospital

Zibo, China

Actively Recruiting

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Research Team

C

Clinical Project Manager

CONTACT

S

Senior Medical Advisor, M.D., Ph.D

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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