Actively Recruiting
Decreasing Cardiometabolic Risk in Childhood Cancer Survivors: The STRENGTH Study Evaluating Time-Restricted Eating with Motivational Coaching
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-05-27
300
Participants Needed
4
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether combining motivational sessions with time-restricted eating (TRE) can help adult survivors of childhood cancer lose weight and reduce cardiometabolic risk. The study compares this approach to the usual care, which consists of reviewing educational materials and monthly weight measurements. This research focuses on weight management and does not provide treatment for any cancer or disease. Participants in the intervention group will gradually build up to a daily 16-hour fasting period, avoiding calorie-containing foods and drinks during this time. They will receive motivational coaching calls bi-weekly for the first three months, then monthly, along with daily text reminders and monthly weight checks. The comparison group will receive standard educational materials and monthly weight monitoring through an online platform. During the study, participants will complete questionnaires about health beliefs, worry, and physical activity. They will also provide dried blood spot samples at home to measure glucose, insulin, hemoglobin A1c, and lipids. Weight and other body measurements will be collected remotely. The main outcome is the percent change in weight after 12 months, with additional measures including changes in glucose, insulin, and hemoglobin A1c levels. The study will monitor participants over a 12-month period with regular check-ins and data collection.
CONDITIONS
Brief Title
A Study of Time-Restricted Eating in Childhood Cancer Survivors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Enrolled in the Childhood Cancer Survivor Study (5+ year survivors diagnosed under age 21 between 1970-1999)
- 18 years old or older
- Body mass index (BMI) of 25 kg/m2 or higher
- Not pregnant and no plans to become pregnant in the next year
- Stable weight over the past 3 months within plus or minus 10 pounds
- Stable medication dose for insulin resistance, high blood pressure, or dyslipidemia if applicable for over 3 months
- Have internet access via smartphone or computer (device provided if needed)
You will not qualify if you...
- Do not live in the United States
- Do not speak English
- Eating window less than 12 hours per day
- Currently using insulin or GLP-1 agonist medications
- Diagnosed with type 1 diabetes mellitus
- Enrolled in another formal weight management or weight loss program
- History of an eating disorder
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (remote)
Duration - 12 months
Participants follow assigned interventions: the experimental group engages in time-restricted eating with motivational coaching and monthly weight check-ins; the control group receives educational materials and monthly weight check-ins. Both groups complete questionnaires and provide dried blood spot samples remotely.
Bi-weekly calls for months 1-3, monthly calls for months 4-6 (intervention group); monthly weight check-ins (all participants)
Trial Site Locations
Total: 4 locations
1
Hunter College
New York, New York, United States, 10065
Not Yet Recruiting
2
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
3
St. Jude Children's Research Hospital (Data Collection Only)
Memphis, Tennessee, United States, 38105
Actively Recruiting
4
Fred Hutchinson Cancer Research Center (Data Collection Only)
Seattle, Washington, United States, 98109
Not Yet Recruiting
Research Team
D
Danielle Friedman, MD
C
Chaya Moskowitz, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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