Actively Recruiting
Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)
Led by Daiichi Sankyo · Updated on 2026-03-05
582
Participants Needed
180
Research Sites
358 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This clinical trial is designed to evaluate the efficacy and safety of T-DXd in combination with bevacizumab versus bevacizumab monotherapy as first-line maintenance therapy, in participants with human epidermal growth factor 2 (HER2)-expressing (immunohistochemistry \[IHC\] 3+/2+/1+) advanced high-grade epithelial ovarian cancer.
CONDITIONS
Official Title
Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent forms for tissue prescreening and main study participation
- Adults aged 18 years or older at consent
- Histologically confirmed diagnosis of epithelial high-grade ovarian, fallopian tube, or primary peritoneal carcinoma
- Newly diagnosed FIGO Stage III or IV disease
- HER2 expression of 3+, 2+, or 1+ by central testing following 2016 ASCO-CAP gastric cancer IHC guidelines
- Adequate tumor tissue available for HER2 assessment and HRD status determination
- Local HRD or BRCA test results available
- Received up to 6 cycles of bevacizumab with frontline platinum-based chemotherapy and eligible for bevacizumab maintenance
You will not qualify if you...
- Non-epithelial ovarian, fallopian tube, or peritoneal cancer
- Known or suspected deleterious BRCA alteration making patient eligible for PARP inhibitor
- Planned use of PARP inhibitor maintenance therapy
- History of severe hypersensitivity to drug components or other monoclonal antibodies
- Stroke, transient ischemic attack, or subarachnoid hemorrhage within 6 months prior to randomization
- Evidence of bleeding disorders or significant coagulopathy without anticoagulation
- History of hemorrhagic disorders, abdominal fistula, gastrointestinal perforation, or active GI bleeding within 6 months
- Active or ongoing bowel obstruction
- Myocardial infarction within 6 months, symptomatic congestive heart failure (NYHA Class II-IV)
- Corrected QT interval prolongation >480 msec on screening ECG
- History or current interstitial lung disease or pneumonitis requiring steroids, or suspected ILD/pneumonitis not ruled out by imaging
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 180 locations
1
Scripps Clinic
La Jolla, California, United States, 92037
Actively Recruiting
2
Broward Health Medical Center
Fort Lauderdale, Florida, United States, 33316
Actively Recruiting
3
Jupiter Medical Center
Jupiter, Florida, United States, 33458
Actively Recruiting
4
Mount Sinai Medical Center
Miami Beach, Florida, United States, 33140
Actively Recruiting
5
AdventHealth Cancer Institute
Orlando, Florida, United States, 32804
Actively Recruiting
6
Woman's Care FL
St. Petersburg, Florida, United States, 33713
Actively Recruiting
7
Nancy N. & J.C Lewis Cancer & Research Pavillion- St. Josephs/ Candler Health System
Savannah, Georgia, United States, 31405
Actively Recruiting
8
Indiana University
Indianapolis, Indiana, United States, 46202
Actively Recruiting
9
Trials365 LLC
Shreveport, Louisiana, United States, 71103
Actively Recruiting
10
Greater Baltimore Medical Center
Towson, Maryland, United States, 21204
Actively Recruiting
11
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
12
Trinity Health St. Joseph Mercy Ann Arbor
Ann Arbor, Michigan, United States, 48106
Actively Recruiting
13
Corewell Health
Grand Rapids, Michigan, United States, 49503
Actively Recruiting
14
St. Vincent Gynecologic Oncology
Billings, Montana, United States, 59102
Actively Recruiting
15
Valley Health System
Paramus, New Jersey, United States, 07652
Actively Recruiting
16
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York, United States, 10016
Actively Recruiting
17
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029
Actively Recruiting
18
UNC Hospital
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
19
Miami Valley Hospital South
Centerville, Ohio, United States, 45459
Actively Recruiting
20
Legacy Medical Group Gynecologic Oncology
Portland, Oregon, United States, 97210
Actively Recruiting
21
Providence Cancer Center Oncology
Portland, Oregon, United States, 97213
Actively Recruiting
22
St. Lukes University Health Network
Bethlehem, Pennsylvania, United States, 18015
Actively Recruiting
23
Ann B Barshinger Cancer Institute
Lancaster, Pennsylvania, United States, 17601
Actively Recruiting
24
Avera Medical Group Gynecologic
Sioux Falls, South Dakota, United States, 57105
Actively Recruiting
25
Genesiscare St Andrews Hospital
Adelaide, Australia
Actively Recruiting
26
Icon Cancer Centre Wesley
Auchenflower, Australia
Actively Recruiting
27
Icon Cancer Centre Hobart
Hobart, Australia
Actively Recruiting
28
Genesis Care North Shore (Oncology)
St Leonards, Australia
Actively Recruiting
29
Westmead Hospital
Sydney, Australia
Actively Recruiting
30
Medizinische Universitat Innsbruck
Innsbruck, Austria
Actively Recruiting
31
AZ Sint-Lucas
Ghent, Belgium
Actively Recruiting
32
UZ Leuven
Leuven, Belgium
Actively Recruiting
33
Groupe Sante CHC/Clinique du MontLegia
Liège, Belgium
Actively Recruiting
34
CHU UCL Namur
Namur, Belgium
Actively Recruiting
35
Cliniques Universitaires Saint-LUC
Woluwe-Saint-Lambert, Belgium
Actively Recruiting
36
Oncocentro Belo Horizonte
Belo Horizonte, Brazil
Actively Recruiting
37
Centro De Pesquisas Clinica Reichow
Blumenau, Brazil
Actively Recruiting
38
Fundação Doutor Amaral Carvalho
Jaú, Brazil
Actively Recruiting
39
Liga Norte-Rio-Grandense Contra o Cancer
Natal, Brazil
Actively Recruiting
40
Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa Hospital Mae de Deus
Porto Alegre, Brazil
Actively Recruiting
41
Irmandade Da Santa Casa De Misericordia De Porto Alegre
Porto Alegre, Brazil
Actively Recruiting
42
Ceon Pesquisas
Santo André, Brazil
Actively Recruiting
43
Fundacao Faculdade Regional De Medicina De Sao Jose Do Rio Preto
Sao Jose Rio, Brazil
Actively Recruiting
44
BP A Beneficencia Portuguesa de Sao Paulo
São Paulo, Brazil
Actively Recruiting
45
Complex Oncology Center- Plovdiv EOOD
Plovdiv, Bulgaria
Actively Recruiting
46
MHAT Park Hospital EOOD
Plovdiv, Bulgaria
Actively Recruiting
47
MHAT Serdika EOOD
Sofia, Bulgaria
Actively Recruiting
48
UMHAT Sofiamed EOOD
Sofia, Bulgaria
Actively Recruiting
49
UMHAT Tsaritsa Yoanna ISUL EAD
Sofia, Bulgaria
Actively Recruiting
50
Ushato Prof Ivan Chernozemski Ead
Sofia, Bulgaria
Actively Recruiting
51
Beijing Cancer Hospital
Beijing, China
Actively Recruiting
52
The First Hospital of Jilin University
Changchun, China
Actively Recruiting
53
Sichuan University West China Second University Hospital
Chengdu, China
Actively Recruiting
54
Chongqing Cancer Hospital
Chongqing, China
Actively Recruiting
55
The Second Hospital of Dalian Medical University
Dalian, China
Actively Recruiting
56
Fujian Cancer Hospital
Fuzhou, China
Actively Recruiting
57
Sun Yat-Sen University Cancer Center
Guangzhou, China
Actively Recruiting
58
Harbin Medical University - Tumor Hospital
Haerbing, China
Actively Recruiting
59
Hainan General Hospital
Haikou, China
Actively Recruiting
60
Zhejiang Cancer Hospital
Hangzhou, China
Actively Recruiting
61
Women's Hospital School of Medicine Zhejiang University
Hangzhoushi, China
Actively Recruiting
62
Shandong Cancer Hospital
Jinan, China
Actively Recruiting
63
Yunnan Cancer Hospital
Kunming, China
Actively Recruiting
64
Jiangxi Maternal and Child Health Hospital
Nanchang, China
Actively Recruiting
65
Zhong Da Hospital, Southeast University
Nanjing, China
Actively Recruiting
66
Guangxi Medical University Cancer Hopstial
Nanning, China
Actively Recruiting
67
Fudan University Shanghai Cancer Center
Shanghai Shi, China, 200032
Actively Recruiting
68
Liaoning Cancer Hospital & Institute
Shenyang, China
Actively Recruiting
69
Affiliated Hospital (Suzhou First People's Hospital)
Suzhou, China
Actively Recruiting
70
Shanxi Cancer Hospital
Taiyuan, China
Actively Recruiting
71
Tianjin Medical University Cancer Institute & Hospital
Tianjin, China
Actively Recruiting
72
Hubei Cancer Hospital
Wuhan, China
Actively Recruiting
73
Tongji Hospital Tongji Medical College of HUST
Wuhan, China
Actively Recruiting
74
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, China
Actively Recruiting
75
Yantai Yuhuangding Hospital
Yantai, China
Actively Recruiting
76
Henan Cancer Hospital
Zhengzhou, China
Actively Recruiting
77
Fakultni Nemocnice Ostrava
Ostrava-Poruba, Czechia
Actively Recruiting
78
Fakultni Nemocnice Bulovka
Prague, Czechia
Actively Recruiting
79
Fakultni Nemocnice Kralovske Vinohrady
Prague, Czechia
Actively Recruiting
80
Fakultni Nemocnice V Motole
Prague, Czechia
Actively Recruiting
81
Vseobecna Fakultni Nemocnice V Praze
Prague, Czechia
Actively Recruiting
82
Aarhus University Hospital
Aarhus, Denmark
Actively Recruiting
83
Sjællands Universitet Hospital
Roskilde, Denmark
Actively Recruiting
84
Institut Bergonie
Bordeaux, France
Actively Recruiting
85
Centre Georges Francois Leclerc
Dijon, France
Actively Recruiting
86
Hopital Claude Huriez- CHU Lille
Lille, France
Actively Recruiting
87
Centre Leon Berard
Lyon, France
Actively Recruiting
88
CHU Montpellier, Saint Eloi
Montpellier, France
Actively Recruiting
89
Hopital Prive Du Confluent
Nantes, France
Actively Recruiting
90
Hopital Saint Joseph- Paris
Paris, France
Actively Recruiting
91
Hospital Europeen Georges Pompidou
Paris, France
Actively Recruiting
92
CRLCC Eugene Marquis
Rennes, France
Actively Recruiting
93
CHU Saint Etienne
Saint-Etienne, France
Actively Recruiting
94
Gujarat Cancer & Research Institute
Ahmedabad, India
Actively Recruiting
95
Saroj Gupta Cancer Center and Research Institute SGCC&RI
Kolkata, India
Actively Recruiting
96
National Cancer Institute Nagpur
Nagpur, India
Actively Recruiting
97
HCG Manavata Cancer Centre
Nashik, India
Actively Recruiting
98
Ruby Hall Clinic
Pune, India
Actively Recruiting
99
HCG Cancer Centre Vadodara
Vadodara, India
Actively Recruiting
100
King George Hospital
Visakhapatnam, India
Actively Recruiting
101
The Lady Davis Carmel Medical Center
Haifa, Israel
Actively Recruiting
102
Shaare Zedek
Jerusalem, Israel
Actively Recruiting
103
Meir Medical Center
Kfar Saba, Israel
Actively Recruiting
104
Rabin Medical Center-Beilinson Campus
Petah Tikva, Israel
Actively Recruiting
105
Tel Aviv Sourasky Medical Center
Tel Aviv, Israel
Actively Recruiting
106
Sheba Medical Center
Tel Litwinsky, Israel
Actively Recruiting
107
Istituto Tumori Giovanni Paolo II Irccs Ospedale Oncologico Bari
Bari, Italy
Actively Recruiting
108
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS
Bologna, Italy
Actively Recruiting
109
Azienda Ospedaliera Per Lemergenza Cannizzaro
Catania, Italy
Actively Recruiting
110
Humanitas San Pio X
Milan, Italy
Actively Recruiting
111
IEO Istituto Europeo Di Oncologia
Milan, Italy
Actively Recruiting
112
Azienda Socio Sanitaria Territoriale Di Monza (Presidio San Gerardo)
Monza, Italy
Actively Recruiting
113
Istituto Nazionale Tumori Fondazione G. Pascale
Naples, Italy
Actively Recruiting
114
Azienda Ospedaliero Universitaria Pisana
Pisa, Italy
Actively Recruiting
115
Nuovo Ospedale Degli Infermi
Ponderano, Italy
Actively Recruiting
116
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma, Italy
Actively Recruiting
117
Istituto Nazionale Tumori Regina Elena Irccs
Roma, Italy
Actively Recruiting
118
Hyogo Cancer Center
Akashi, Japan, 673-8558
Actively Recruiting
119
National Cancer Center Hospital
Chūōku, Japan, 104-0045
Actively Recruiting
120
Fukushima Medical University Hospital
Fukushima, Japan, 960-1295
Actively Recruiting
121
Saitama Medical University International Medical Center
Hidaka-Shi, Japan, 350-1298
Actively Recruiting
122
Cancer Institute Hospital of JFCR
Kōtoku, Japan, 135-8550
Actively Recruiting
123
Kurume University Hospital
Kurume-shi, Japan
Actively Recruiting
124
Aichi Cancer Center Hospital
Nagoya, Japan
Actively Recruiting
125
Niigata Cancer Center Hospital
Niigata, Japan
Actively Recruiting
126
Okayama University Hosptial
Okayama, Japan, 700-8558
Actively Recruiting
127
Osaka International Cancer Institute
Osaka, Japan
Actively Recruiting
128
Kindai University Hospital
Osakasayama-shi, Japan
Actively Recruiting
129
NHO Hokkaido Cancer Center
Sapporo, Japan, 003-0804
Actively Recruiting
130
Iwate Medical University Hospital
Shiwa-Gun, Japan, 028-3695
Actively Recruiting
131
Shizuoka Cancer Center
Sunto-gun, Japan
Actively Recruiting
132
Mie University Hospital
Tsu, Japan, 514-8507
Actively Recruiting
133
Yamagata University Hospital
Yamagata, Japan, 990-9585
Actively Recruiting
134
Hospital Sultan
Johor Bahru, Malaysia
Actively Recruiting
135
Sarawak General Hospital
Kuching, Malaysia
Actively Recruiting
136
HOSPITAL KUALA LUMPUR(HKL) Kuala
Lumpur, Malaysia
Actively Recruiting
137
National Cancer Institute / Institut Kanser Negara
Putrajaya, Malaysia
Actively Recruiting
138
Mazowiecki Szpital Wojewodzki W Siedlcach SP Zoo
Siedlce, Poland
Actively Recruiting
139
Gral Medical S.R.L
Bucharest, Romania
Actively Recruiting
140
Medeuropa SRL
Bucharest, Romania
Actively Recruiting
141
Memorial Healthcare International SRL
Bucharest, Romania
Actively Recruiting
142
Medeuropa SRL
Oradea, Romania
Actively Recruiting
143
National University Hospital
Singapore, Singapore
Actively Recruiting
144
Keimyung University Dongsan Hospital
Daegu, South Korea
Actively Recruiting
145
National Cancer Center
Goyang-si, South Korea
Actively Recruiting
146
CHA Bundang Medical Center, CHA University
Seongnam-si, South Korea
Actively Recruiting
147
Seoul National University Bundang Hospital
Seongnam-si, South Korea
Actively Recruiting
148
Asan Medical Center
Seoul, South Korea
Actively Recruiting
149
Gangnam Severance Hospital, Yonsei University Health System
Seoul, South Korea
Actively Recruiting
150
Samsung Medical Center
Seoul, South Korea
Actively Recruiting
151
Seoul National University Hospital
Seoul, South Korea
Actively Recruiting
152
Severance Hospital, Yonsei University Health System
Seoul, South Korea
Actively Recruiting
153
The Catholic University of Korea, Seoul St. Mary'S Hospital
Seoul, South Korea
Actively Recruiting
154
Complejo Hospitalario Universitario A Coruna
A Coruña, Spain
Actively Recruiting
155
Hospital Clinic De Barcelona
Barcelona, Spain
Actively Recruiting
156
Hospital Universitari Vall D'Hebron
Barcelona, Spain
Actively Recruiting
157
Hospital Universitario Reina Sofia
Córdoba, Spain
Actively Recruiting
158
Hospital Universitario Virgen De La Arrixaca
El Palmar, Spain
Actively Recruiting
159
Hospital Universitario 12 de Octubre
Madrid, Spain
Actively Recruiting
160
Hospital Universitario La Paz
Madrid, Spain
Actively Recruiting
161
Hospital Universitario Ramon y Cajal
Madrid, Spain
Actively Recruiting
162
Hospital Universitari Son Espases
Palma, Spain
Actively Recruiting
163
Clinica Universidad de Navarra (MAD)
Pamplona, Spain
Actively Recruiting
164
Hospital Universitario Donostia
Planta Baja, Spain
Actively Recruiting
165
Clinica Universidad de Navarra (Calle Marquesado de Santa Marta)
San Blas-Canillejas, Spain
Actively Recruiting
166
Hospital Universitario Virgen del Rocio
Seville, Spain
Actively Recruiting
167
Hospital Clinico Universitario De Valencia
Valencia, Spain
Actively Recruiting
168
Hospital Universitari I Politecnic La Fe
Valencia, Spain
Actively Recruiting
169
Skanes Universitetssjukhus Lund
Lund, Sweden
Actively Recruiting
170
Karolinska Universitet Ssjukhuset
Solna, Sweden
Actively Recruiting
171
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Taiwan
Actively Recruiting
172
Chang Gung Memorial Hospital
Linkou Taoyuan, Taiwan
Actively Recruiting
173
Taichung Veterans General Hospital
Taichung, Taiwan
Actively Recruiting
174
National Cheng Kung University Hospital
Tainan, Taiwan
Actively Recruiting
175
MacKay Memorial Hospital- Taipei Branch
Taipei, Taiwan
Actively Recruiting
176
National Taiwan University Hospital
Taipei, Taiwan
Actively Recruiting
177
Taipei Veterans General Hospital
Taipei, Taiwan
Actively Recruiting
178
Addenbrooke's Hospital
Cambridge, United Kingdom
Actively Recruiting
179
Barts Health NHS Trust
London, United Kingdom
Actively Recruiting
180
The Christie Hospital
Manchester, United Kingdom
Actively Recruiting
Research Team
C
Contact for Trial Information
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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