Actively Recruiting
A Study of Trastuzumab DeRuxtecan for Patients With Advanced HER2-pOsitive GaStric or GastroesoPhageal Junction AdEnocarcinoma Who Have Received a PrIor Trastuzumab-based Regimen Accompanied by a Disease RegistrY of Patients Treated With Conventional Therapies (PROSPERITY)
Led by Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company · Updated on 2026-05-08
257
Participants Needed
76
Research Sites
195 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Trastuzumab deruxtecan (T-DXD) as monotherapy is indicated for the treatment of adult patients with advanced HER2-positive advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma who have received a prior trastuzumab-based regimen. This study will assess the effectiveness of T-DXd, patient demographic and clinical characteristics, and treatment patterns in patients with advanced HER2-positive advanced gastric or GEJ adenocarcinoma.
CONDITIONS
Official Title
A Study of Trastuzumab DeRuxtecan for Patients With Advanced HER2-pOsitive GaStric or GastroesoPhageal Junction AdEnocarcinoma Who Have Received a PrIor Trastuzumab-based Regimen Accompanied by a Disease RegistrY of Patients Treated With Conventional Therapies (PROSPERITY)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult male or female patients aged 18 years or older with HER2-positive advanced gastric or gastroesophageal junction adenocarcinoma
- Histological or cytological confirmed diagnosis of advanced HER2-positive gastric cancer or GEJ
- Documented HER2-positive status from an archival or recent sample before second-line therapy
- Decision made to start monotherapy with trastuzumab deruxtecan or conventional therapies according to physician's choice
- Signed and dated informed consent to participate in the study
You will not qualify if you...
- Participation in a blinded interventional study at time of data collection or previous participation in such a study
- Pregnancy or breastfeeding
- No other specific exclusion criteria; patients will be treated according to the SmPC indication statements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 76 locations
1
KABEG Klinikum Klagenfurt am Wörthersee - Landeskrankenanstalten LKH
Klagenfurt, Austria, 9020
Withdrawn
2
Ordensklinikum Linz GmbH Barmherzige Schwestern
Linz, Austria, 4010
Active, Not Recruiting
3
Universitätsklinikum St. Pölten - Lilienfeld
Sankt Pölten, Austria, 3100
Withdrawn
4
Medizinische Universität Wien
Vienna, Austria, 1090
Active, Not Recruiting
5
St. Josef Krankenhaus GmbH Ein Unternehmen der Vinzenz Gruppe
Vienna, Austria, 1130
Withdrawn
6
Klinik Ottakring, Wilhelminenspital der Stadt Wien
Vienna, Austria, 1160
Withdrawn
7
Kepler Universitätsklinikum
Wels, Austria, 4600
Active, Not Recruiting
8
Landesklinikum Wiener Neustadt
Wiener Neustadt, Austria, 2700
Active, Not Recruiting
9
Krankenhaus St. Vinzenz in Zams
Zams, Austria, 6511
Active, Not Recruiting
10
OLV Hospital Aalst
Aalst, Belgium, 9300
Active, Not Recruiting
11
Imelda vzw
Bonheiden, Belgium, 1090
Withdrawn
12
HUB institut Jules Bordet
Brussels, Belgium, 1070
Withdrawn
13
Grand hôpital de Charleroi
Charleroi, Belgium, 6000
Withdrawn
14
Antwerp University Hospital
Edegem, Belgium, 2650
Active, Not Recruiting
15
UZ Gent
Ghent, Belgium, 9000
Active, Not Recruiting
16
CHU Helora Hospital de La Louvière - Site Jolimont
Haine-Saint-Paul, Belgium, 7100
Active, Not Recruiting
17
JESSA Hasselt
Hasselt, Belgium, 3500
Active, Not Recruiting
18
UZ Brussel
Jette, Belgium, 3000
Active, Not Recruiting
19
UZ Leuven
Leuven, Belgium, 3000
Withdrawn
20
AZ Delta
Roeselare, Belgium, 8800
Withdrawn
21
MVZ am Klinikum Aschaffenburg
Aschaffenburg, Germany, 63739
Active, Not Recruiting
22
Universitätsklinikum Augsburg
Augsburg, Germany, 86156
Withdrawn
23
Vivantes Klinikum im Friedrichshain
Berlin, Germany, 10249
Active, Not Recruiting
24
Charite Campus Benjamin Franklin
Berlin, Germany, 12203
Active, Not Recruiting
25
Klinikum Chemnitz gGmbH
Chemnitz, Germany, 09116
Withdrawn
26
MV-Zentrum für Hämatologie & Onkologie
Cologne, Germany, 50677
Active, Not Recruiting
27
Universitätsklinikum Düsseldorf
Düsseldorf, Germany, 40225
Withdrawn
28
University Hospital Essen
Essen, Germany, 45147
Active, Not Recruiting
29
Universitaetsklinikum Giessen und Marburg, Standort Giessen
Giessen, Germany, 35392
Withdrawn
30
Alb Fils Kliniken GmbH
Göppingen, Germany, 73035
Active, Not Recruiting
31
Hämatologisch-Onkologische Praxis Eppendorf (HOPE)
Hamburg, Germany, 20249
Active, Not Recruiting
32
Studienzentrum am Raschplatz GbR
Hanover, Germany, 30161
Active, Not Recruiting
33
KRH Klinikum Siloah
Hanover, Germany, 30459
Active, Not Recruiting
34
Gemeinschaftspraxis Dr. Haytham Kamal / Dr. David C. Dorn
Hanover, Germany, 30625
Active, Not Recruiting
35
Städtisches Klinikum Karlsruhe
Karlsruhe, Germany, 76133
Withdrawn
36
ÜBAG MVZ Mitte / MVZ Delitzsch GmbH
Leipzig, Germany, 04103
Withdrawn
37
Praxis Hämatologie und Onkologie Magdeburg
Magdeburg, Germany, 39104
Withdrawn
38
Universitätsklinik für Gastroenterologie, Hepatologie und Infektiologie
Magdeburg, Germany, 39120
Withdrawn
39
Klinikum rechts der Isar der Technischen Universität München
München, Germany, 81675
Active, Not Recruiting
40
Pi.Tri-Studien GmbH
Offenburg, Germany, 77654
Withdrawn
41
Klinikum am Steinenberg Reutlingen
Reutlingen, Germany, 72764
Active, Not Recruiting
42
Nädler GmbH
Rinteln, Germany, 31737
Withdrawn
43
CaritasKlinikum Saarbrücken
Saarbrücken, Germany, 66113
Active, Not Recruiting
44
Praxis Onkologie Rheinsieg
Troisdorf, Germany, 53840
Active, Not Recruiting
45
Universitätsklinikum Würzburg (UKW)
Würzburg, Germany, 97080
Withdrawn
46
AOU delle Marche
Ancona Torrette, Italy, 60126
Withdrawn
47
ASL AT - Presidio Ospedaliero "Cardinal Massaia"
Asti, Italy, 14100
Withdrawn
48
IRCCS "S. De Bellis"
Castellana Grotte, Italy, 70013
Actively Recruiting
49
ARNAS Garibaldi - PO Nesima
Catania, Italy, 95122
Actively Recruiting
50
AOU Careggi
Florence, Italy, 50134
Actively Recruiting
51
IRCCS AOU San Martino
Genova, Italy, 16132
Actively Recruiting
52
IRCCS Ospedale San Raffaele
Milan, Italy, 20132
Actively Recruiting
53
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy, 20133
Actively Recruiting
54
Azienda Ospedaliero-Universitaria di Modena
Modena, Italy, 41124
Actively Recruiting
55
A.O.U. Cagliari - Policlinico Universitario Duilio Casula
Monserrato, Italy, 09042
Withdrawn
56
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale
Naples, Italy, 80131
Actively Recruiting
57
Università degli studi di Napoli Federico II
Naples, Italy, 80131
Actively Recruiting
58
Università della Campania 'Luigi Vanvitelli'
Naples, Italy, 80131
Actively Recruiting
59
AOU Pisana - Stabilimento Santa Chiara
Pisa, Italy, 56126
Actively Recruiting
60
Azienda Sanitaria Locale di Biella - Ospedale degli Infermi
Ponderano, Italy, 13875
Withdrawn
61
AUSL della Romagna - Ospedale "S. Maria delle Croci" di Ravenna
Ravenna, Italy, 48121
Actively Recruiting
62
Policlinico Universitario Campus Bio-Medico
Roma, Italy, 00128
Actively Recruiting
63
AO San Camillo Forlanini
Roma, Italy, 00182
Withdrawn
64
AO San Giovanni Addolorata
Roma, Italy, 00184
Withdrawn
65
IRCCS Ospedale Casa Sollievo della Sofferenza
San Giovanni Rotondo, Italy, 71013
Withdrawn
66
AO "Cardinale Giovanni Panico"
Tricase, Italy, 73039
Actively Recruiting
67
ASU FC - Ospedale "Santa Maria della Misericordia"
Udine, Italy, 33100
Withdrawn
68
Azienda ULSS 8 Berica - Ospedale San Bortolo
Vicenza, Italy, 36100
Withdrawn
69
ULS Almada-Seixal
Almada, Portugal, 2805-267
Withdrawn
70
USL Braga
Braga, Portugal, 4710-243
Withdrawn
71
ULS Coimbra
Coimbra, Portugal, 3004-561
Withdrawn
72
IPO Lisboa
Lisbon, Portugal, 1099-023
Withdrawn
73
CC Champalimaud
Lisbon, Portugal, 1400-038
Withdrawn
74
Hospital da Luz
Lisbon, Portugal, 1500-650
Withdrawn
75
ULS Santo António
Porto, Portugal, 4050-342
Withdrawn
76
Vila Real
Vila Real, Portugal, 5000-508
Withdrawn
Research Team
C
Contact for Clinical Trial Information
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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