Actively Recruiting
Study on Treatment Decision-Making and Prognostic Follow-Up for Untreated Cerebral Cavernous Malformations
Led by Beijing Tiantan Hospital · Updated on 2025-07-30
1200
Participants Needed
1
Research Sites
304 weeks
Total Duration
On this page
Sponsors
B
Beijing Tiantan Hospital
Lead Sponsor
R
RenJi Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to evaluate and predict the risk associated with cerebral cavernous malformations (CCMs) using advanced artificial intelligence and radiomics analysis technology. The study focuses on individuals who have been diagnosed with cerebral cavernous malformations (CCMs). Main Questions to Answer: How can AI-based radiomics features predict the risk of complications (such as bleeding or epilepsy) in individuals with CCMs? What are the most reliable imaging and clinical markers for assessing the prognosis of CCMs? Participants will be required to undergo regular medical imaging to gather traditional and radiomics imaging features. Participants will provide clinical data, including past medical history and results of any laboratory tests. Participants will be part of a three-year follow-up observation to monitor the progression or stability of CCMs. Contribution of biological samples for advanced testing might also be requested. This study aims to create an AI-based decision-making tool that will guide clinicians in the management of CCM, with the potential to significantly improve patient outcomes through personalized medical approaches.
CONDITIONS
Official Title
Study on Treatment Decision-Making and Prognostic Follow-Up for Untreated Cerebral Cavernous Malformations
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of CCM based on brain MRI (T1, T2, SWI, and T2-Fluid-Attenuated Inversion Recovery)
- No previous invasive treatment such as surgery, radiotherapy, or multimodal therapy
- Agreement to collect lesion tissue samples if undergoing surgery, with signed consent
- Agreement to collect imaging data if under conservative observation, with signed consent
- Willingness to participate in long-term follow-up
You will not qualify if you...
- Acute intracranial symptomatic hemorrhage requiring emergency surgery
- Presence of other intracranial diseases like aneurysms, tumors, or vascular malformations (excluding developmental venous anomalies)
- Severe underlying diseases affecting functional status and life expectancy
- Severe psychiatric or psychological disorders
- Incomplete clinical or imaging data
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Capital Medical University Affiliated Beijing Tiantan Hospital
Beijing, Beijing Municipality, China
Actively Recruiting
Research Team
S
shuo wang
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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