PERSEVERE: longitudinal assessment of quality of life and treatment toxicities in Chinese breast cancer patients - a multicentre cohort study protocol.
Zheng Qu, Haijun Wang, Qi Li...
https://pubmed.ncbi.nlm.nih.gov/41922058Actively Recruiting
Age: 18Years +
FEMALE
Healthy Volunteers
ID07010939
A Prospective Multi-modal Cohort Study of Local Treatment-related Toxicities and Quality of Life in Chinese Breast Cancer Patients (PERSEVERE)
Led by FangYi · Updated on 2025-09-12
3000
Participants Needed
3
Research Sites
34 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the effects of local treatment on health and daily life in people with early-stage breast cancer in China. The focus is on those with stage I to III invasive breast cancer receiving surgery and other therapies before or after surgery. The study aims to understand both short- and long-term physical, emotional, and social effects of treatment, including tiredness, sleep problems, emotional distress, pain, and changes in heart or lung function, to improve recovery and quality of life. Participants will receive local therapy with curative intent, which may include surgery, chemotherapy, radiotherapy, endocrine therapy, or targeted therapy given before or after surgery. This observational study involves no experimental treatment. At the start, participants undergo clinical assessments, including heart and lung tests, lab work, and collection of blood and tissue samples. They also complete questionnaires about symptoms and well-being at multiple time points over five years. During the study, participants will complete surveys about their physical symptoms, emotional health, and quality of life at baseline, one week, one month, three months, six months, one year, and then annually up to five years. Researchers will monitor treatment-related toxicities and quality of life changes through these patient-reported outcomes. The study uses electronic data collection with quality checks to ensure accurate and consistent information for analysis and future research.
CONDITIONS
Brief Title
A Study of Treatment-Related Toxicities and Quality of Life After Local Therapy in Chinese Breast Cancer Patients
Who Can Participate
Age: 18Years +
FEMALE
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Women aged 18 years or older
- Diagnosed with stage I, II, or III invasive breast cancer confirmed by pathology or cytology
- No signs of metastatic disease
- Scheduled to receive local treatment including surgery and/or neoadjuvant or adjuvant therapy such as chemotherapy, radiation, hormone therapy, or targeted therapy
- Willing and able to complete health questionnaires and attend follow-up visits
- Provided written informed consent to join the study
You will not qualify if you...
- Have metastatic breast cancer or local recurrence
- Have already received curative treatment for current breast cancer before joining
- Currently pregnant or breastfeeding
- History of another cancer within past 5 years except non-melanoma skin cancer or in-situ cervical cancer
- Unable to participate due to mental, physical, or legal reasons, such as legal guardianship or imprisonment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Baseline visit
Participants undergo baseline clinical assessments and biospecimen collection to evaluate their health status before local therapy.
1 visit (in-person)
Long-term Monitoring
Duration - Up to 5 years
Participants complete electronic questionnaires to monitor treatment-related toxicities and quality of life after local therapy over time.
Questionnaire assessments at postoperative week 1, month 1, month 3, and every 6-12 months thereafter
Trial Site Locations
Total: 3 locations
1
National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Beijing, Beijing Municipality, China, 100021
Actively Recruiting
2
Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center
Shenzhen, Guangdong, China, 518116
Active, Not Recruiting
3
Shanxi Cancer Hospital
Taiyuan, Shanxi, China, 030013
Active, Not Recruiting
Loading map...
Research Team
Z
Zheng Qu, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here