MOUNTAINEER-03 phase III study design: first-line mFOLFOX6 + tucatinib + trastuzumab for HER2+ metastatic colorectal cancer.
John H Strickler, Tanios Bekaii-Saab, Andrea Cercek...
https://pubmed.ncbi.nlm.nih.gov/39723627Actively Recruiting
Phase 3
Age: 18Years +
All Genders
ID05253651
An Open-label Randomized Phase 3 Study of Tucatinib with Trastuzumab and mFOLFOX6 Versus mFOLFOX6 with or without Cetuximab or Bevacizumab as First-line Treatment for HER2+ Metastatic Colorectal Cancer
Led by Seagen, a wholly owned subsidiary of Pfizer · Updated on 2026-06-04
400
Participants Needed
381
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether adding tucatinib to trastuzumab and mFOLFOX6 works better than the current standard treatments for people with HER2 positive metastatic colorectal cancer. This study focuses on participants whose cancer has spread or cannot be removed by surgery. The trial also monitors side effects that might occur from taking these drug combinations. Participants are randomly assigned to one of two groups. One group receives tucatinib taken orally twice daily along with trastuzumab given intravenously every three weeks and mFOLFOX6 chemotherapy every two weeks. The other group receives standard care, which includes mFOLFOX6 alone or combined with bevacizumab or cetuximab given by intravenous infusion. The study treatments continue as per the assigned schedule. During the study, participants undergo regular scans and evaluations to measure progression-free survival and other outcomes up to approximately three years. Researchers also assess overall survival, response rates, duration of response, quality of life, and side effects for up to about six years. Safety monitoring continues for around one year after the last treatment. Participants are closely followed to understand the impact of these treatments on their cancer and well-being.
CONDITIONS
Brief Title
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Histologically or cytologically confirmed adenocarcinoma of the colon or rectum that is locally advanced unresectable or metastatic
- Able to provide recent tumor tissue samples before treatment
- HER2 positive disease confirmed by central lab assay
- RAS wild-type disease confirmed by testing within 1 year of biopsy
- At least one measurable tumor site per RECIST v1.1 criteria
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- No evidence of brain metastases or previously treated asymptomatic brain metastases
You will not qualify if you...
- Prior systemic anticancer therapy for colorectal cancer in metastatic or unresectable setting, except up to 2 doses of mFOLFOX6
- Radiation therapy within 14 days before enrollment (7 days for stereotactic radiosurgery)
- Previous treatment with anti-HER2 therapy
- Ongoing Grade 3 or higher neuropathy
- Active or untreated gastrointestinal perforation at screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
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3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Up to approximately 3 years
Participants receive active treatment with either tucatinib plus trastuzumab and mFOLFOX6 or standard of care treatment involving mFOLFOX6 with or without bevacizumab or cetuximab.
Visits every 2 to 3 weeks for drug administration and monitoring
Follow-up
Duration - Up to approximately 3 years after treatment
Participants are monitored for overall survival, adverse events, dose alterations, and quality of life after treatment ends.
Periodic visits for up to 1 year after last treatment
Trial Site Locations
Total: 381 locations
1
Palo Verde Hematology Oncology
Glendale, Arizona, United States, 85304
Actively Recruiting
2
Mayo Clinic Building - Phoenix
Phoenix, Arizona, United States, 85054
Actively Recruiting
3
Mayo Clinic Hospital
Phoenix, Arizona, United States, 85054
Actively Recruiting
4
Mayo Clinic
Scottsdale, Arizona, United States, 85259
Actively Recruiting
5
Los Angeles Cancer Network - Anaheim
Anaheim, California, United States, 92801
Actively Recruiting
6
Kaiser Permanente Anaheim Kraemer Medical Offices
Anaheim, California, United States, 92806
Active, Not Recruiting
7
Kaiser Permanente Baldwin Park Medical Center
Baldwin Park, California, United States, 91706
Active, Not Recruiting
8
Kaiser Permanente Bellflower Medical Offices
Bellflower, California, United States, 90706
Active, Not Recruiting
9
Kaiser Permanente Fontana Medical Center
Fontana, California, United States, 92335
Active, Not Recruiting
10
Los Angeles Cancer Network - Fountain Vally
Fountain Valley, California, United States, 92708
Actively Recruiting
11
Los Angeles Hematology Oncology Medical Group
Glendale, California, United States, 91204
Actively Recruiting
12
Los Angeles Hematology Oncology Medical Group
Glendale, California, United States, 91206
Actively Recruiting
13
Kaiser Permanente South Bay Medical center
Harbor City, California, United States, 90710
Active, Not Recruiting
14
Kaiser Permanente Alton/Sand Canyon Medical Offices
Irvine, California, United States, 92618
Active, Not Recruiting
15
Los Angeles Hematology Oncology Medical Group
Los Angeles, California, United States, 90017
Actively Recruiting
16
USC Norris Koreatown - Medical Oncology
Los Angeles, California, United States, 90020
Terminated
17
Kaiser Permanente Los Angeles Medical Offices
Los Angeles, California, United States, 90027
Active, Not Recruiting
18
Keck Hospital of USC
Los Angeles, California, United States, 90033
Terminated
19
Los Angeles General Medical Center
Los Angeles, California, United States, 90033
Terminated
20
University of Southern California
Los Angeles, California, United States, 90033
Terminated
21
USC/Norris Comprehensive Cancer Center
Los Angeles, California, United States, 90033
Terminated
22
Kaiser Permanente West Los Angeles Medical Center
Los Angeles, California, United States, 90034
Active, Not Recruiting
23
USC Norris Oncology/Hematology - Newport Beach
Newport Beach, California, United States, 92663
Terminated
24
Kaiser Permanente Ontario Medical Center
Ontario, California, United States, 91761
Active, Not Recruiting
25
Kaiser Permanente Panorama City Medical Center
Panorama City, California, United States, 91402
Active, Not Recruiting
26
Keck Medical Center of USC Pasadena
Pasadena, California, United States, 91105
Terminated
27
Los Angeles Hematology Oncology Medical Group
Pasadena, California, United States, 91105
Actively Recruiting
28
Kaiser Permanente Riverside Medical Center
Riverside, California, United States, 92505
Active, Not Recruiting
29
Kaiser Permanente San Diego Mission Road (Regulatory and Lab Supplies)
San Diego, California, United States, 92108
Active, Not Recruiting
30
Kaiser Permanente Zion Medical Center
San Diego, California, United States, 92120
Active, Not Recruiting
31
Kaiser Permanente San Marcos Medical Offices
San Marcos, California, United States, 92078
Active, Not Recruiting
32
Los Angeles Hematology Oncology Medical Group
Van Nuys, California, United States, 91405
Actively Recruiting
33
Kaiser Permanente Woodland Hills Medical Center
Woodland Hills, California, United States, 91367
Active, Not Recruiting
34
Rocky Mountain Cancer Centers, LLP
Aurora, Colorado, United States, 80012
Actively Recruiting
35
Rocky Mountain Cancer Centers, LLP
Boulder, Colorado, United States, 80303
Actively Recruiting
36
Rocky Mountain Cancer Centers, LLP
Colorado Springs, Colorado, United States, 80907
Actively Recruiting
37
Rocky Mountain Cancer Centers, LLP
Denver, Colorado, United States, 80218
Actively Recruiting
38
Rocky Mountain Cancer Centers, LLP
Denver, Colorado, United States, 80220
Actively Recruiting
39
Rocky Mountain Cancer Centers, LLP
Lakewood, Colorado, United States, 80228
Actively Recruiting
40
Rocky Mountain Cancer Centers, LLP
Littleton, Colorado, United States, 80120
Actively Recruiting
41
Rocky Mountain Cancer Centers, LLP
Lone Tree, Colorado, United States, 80124
Actively Recruiting
42
Rocky Mountain Cancer Centers, LLP
Longmont, Colorado, United States, 80504
Actively Recruiting
43
Rocky Mountain Cancer Centers, LLP
Pueblo, Colorado, United States, 81003
Actively Recruiting
44
Rocky Mountain Cancer Centers, LLP
Thornton, Colorado, United States, 80260
Actively Recruiting
45
Mount Sinai Medical Center Aventura ER
Aventura, Florida, United States, 33180
Actively Recruiting
46
Mount Sinai Comprehensive Cancer Center
Miami Beach, Florida, United States, 33140
Actively Recruiting
47
Mount Sinai Medical Center
Miami Beach, Florida, United States, 33140
Actively Recruiting
48
Grady Health System
Atlanta, Georgia, United States, 30303
Actively Recruiting
49
Emory University Hospital Midtown
Atlanta, Georgia, United States, 30308
Actively Recruiting
50
Emory University Hospital
Atlanta, Georgia, United States, 30322
Actively Recruiting
51
Winship Cancer Institute
Atlanta, Georgia, United States, 30322
Actively Recruiting
52
Alliance for Multispecialty Research LLC.
Merriam, Kansas, United States, 66204
Terminated
53
Baptist Health Lexington
Lexington, Kentucky, United States, 40503
Actively Recruiting
54
Norton Cancer Institute - Downtown
Louisville, Kentucky, United States, 40202
Actively Recruiting
55
Norton Cancer Institute, Downtown
Louisville, Kentucky, United States, 40202
Actively Recruiting
56
Norton Hospital
Louisville, Kentucky, United States, 40202
Actively Recruiting
57
Norton Audubon Hospital
Louisville, Kentucky, United States, 40217
Actively Recruiting
58
Norton Cancer Institute, Audubon Hospital Campus
Louisville, Kentucky, United States, 40217
Actively Recruiting
59
Norton Brownsboro Hospital
Louisville, Kentucky, United States, 40241
Actively Recruiting
60
Norton Cancer Institute, Brownsboro Hospital Campus
Louisville, Kentucky, United States, 40241
Actively Recruiting
61
Minnesota Oncology Hematology, PA
Burnsville, Minnesota, United States, 55337
Actively Recruiting
62
Allina Health Cancer institute
Coon Rapids, Minnesota, United States, 55433
Actively Recruiting
63
Minnesota Oncology Hematology, PA
Coon Rapids, Minnesota, United States, 55433
Actively Recruiting
64
M Health Fairview Cancer Clinic-Edina
Edina, Minnesota, United States, 55435
Actively Recruiting
65
Minnesota Oncology Hematology, PA
Edina, Minnesota, United States, 55435
Actively Recruiting
66
Minnesota Oncology Hematology, PA
Fridley, Minnesota, United States, 55432
Actively Recruiting
67
Minnesota Oncology Hematology, PA
Maple Grove, Minnesota, United States, 55369
Actively Recruiting
68
M Health Fairview St. John's Hospital
Maplewood, Minnesota, United States, 55109
Actively Recruiting
69
Minnesota Oncology Hematology, PA
Maplewood, Minnesota, United States, 55109
Actively Recruiting
70
Allina Health Cancer Institute (Virginia Piper Cancer Institute)
Minneapolis, Minnesota, United States, 55404
Actively Recruiting
71
Minnesota Oncology Hematology, PA
Minneapolis, Minnesota, United States, 55404
Actively Recruiting
72
Hennepin County Medical Center
Minneapolis, Minnesota, United States, 55415
Actively Recruiting
73
North Memorial Health Cancer Center
Robbinsdale, Minnesota, United States, 55422
Actively Recruiting
74
Mayo Clinic Cancer Center Outpatient Pharmacy
Rochester, Minnesota, United States, 55905
Actively Recruiting
75
Metro Minnesota Community Oncology Research Consortium
Saint Louis Park, Minnesota, United States, 55416
Actively Recruiting
76
Park Nicollet Frauenshuh Cancer Center
Saint Louis Park, Minnesota, United States, 55426
Actively Recruiting
77
Regulatory Location: MMCORC
Saint Louis Park, Minnesota, United States, 55426
Actively Recruiting
78
Regions Hospital
Saint Paul, Minnesota, United States, 55101
Actively Recruiting
79
Allina Health Cancer Institute-United(VPCI)
Saint Paul, Minnesota, United States, 55102
Actively Recruiting
80
Minnesota Oncology Hematology, PA Cornerstone Medical Specialty Center
Woodbury, Minnesota, United States, 55125
Actively Recruiting
81
MSK Basking Ridge
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
82
MSK Monmouth
Middletown, New Jersey, United States, 07748
Actively Recruiting
83
MSK Bergen
Montvale, New Jersey, United States, 07645
Actively Recruiting
84
MSK Commack
Commack, New York, United States, 11725
Actively Recruiting
85
MSK Westchester
Harrison, New York, United States, 10604
Actively Recruiting
86
Rockefeller Outpatient Pavilion (53rd Street)
New York, New York, United States, 10022
Actively Recruiting
87
Memorial Solan Kettering Cancer Center- Main Campus
New York, New York, United States, 10065
Actively Recruiting
88
MSK Nassau
Uniondale, New York, United States, 11553
Actively Recruiting
89
Duke University Hospital
Durham, North Carolina, United States, 27710
Actively Recruiting
90
Duke University Medical Center, Duke Cancer Center
Durham, North Carolina, United States, 27710
Actively Recruiting
91
Duke University Medical Center
Durham, North Carolina, United States, 27710
Actively Recruiting
92
FirstHealth Cancer Center
Pinehurst, North Carolina, United States, 28374
Actively Recruiting
93
FirstHealth Moore Regional Hospital
Pinehurst, North Carolina, United States, 28374
Actively Recruiting
94
Gabrail Cancer Center Research
Canton, Ohio, United States, 44718
Terminated
95
Northwest Cancer Specialists, P.C.
Portland, Oregon, United States, 97213
Actively Recruiting
96
Providence Cancer Institute Franz Clinic
Portland, Oregon, United States, 97213
Actively Recruiting
97
Providence Portland Medical Center
Portland, Oregon, United States, 97213
Actively Recruiting
98
Providence Oncology and Hematology Care Clinic - Westside
Portland, Oregon, United States, 97225
Actively Recruiting
99
Providence St. Vincent Medical Center
Portland, Oregon, United States, 97225
Actively Recruiting
100
Northwest Cancer Specialists, P.C.
Portland, Oregon, United States, 97227
Actively Recruiting
101
Northwest Cancer Specialists, P.C.
Tigard, Oregon, United States, 97223
Actively Recruiting
102
UPMC Hillman Cancer Center - Beaver
Beaver, Pennsylvania, United States, 15009
Actively Recruiting
103
UPMC Hillman Cancer Center at Butler Health System
Butler, Pennsylvania, United States, 16001
Actively Recruiting
104
UPMC Hillman Cancer Center Erie
Erie, Pennsylvania, United States, 16505
Actively Recruiting
105
UPMC Hillman Cancer Center at Arnold Palmer Pavilion, In Partnership with Excela Health
Greensburg, Pennsylvania, United States, 15601
Actively Recruiting
106
UPMC Hillman Cancer Center - Pinnacle (Community Osteopathic / Medical Sciences Pavillion)
Harrisburg, Pennsylvania, United States, 17109
Actively Recruiting
107
UPMC Hillman Cancer Center at Arnold Palmer Pavilion, In Partnership with Excela Health
Irwin, Pennsylvania, United States, 15642
Actively Recruiting
108
UPMC Hillman Cancer Center - Pinnacle (Ortenzio)
Mechanicsburg, Pennsylvania, United States, 17050
Actively Recruiting
109
UPMC Hillman Cancer Center - Monroeville
Monroeville, Pennsylvania, United States, 15146
Actively Recruiting
110
UPMC Hillman Cancer Center - St Margarets
Pittsburgh, Pennsylvania, United States, 15215
Actively Recruiting
111
UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
112
UPMC Hillman Cancer Center - Passavant (HOA)
Pittsburgh, Pennsylvania, United States, 15237
Actively Recruiting
113
St. Clair Cancer Center Medical Oncology
Pittsburgh, Pennsylvania, United States, 15243
Actively Recruiting
114
UPMC Hillman Cancer Center - Washington
Washington, Pennsylvania, United States, 15301
Actively Recruiting
115
Avera Cancer Institute
Sioux Falls, South Dakota, United States, 57105
Actively Recruiting
116
Henry-Joyce Cancer Clinic
Nashville, Tennessee, United States, 37232
Actively Recruiting
117
Texas Oncology - DFW
Dallas, Texas, United States, 75246
Actively Recruiting
118
The University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
119
US Oncology Investigational Product Center (IPC)
Irving, Texas, United States, 75063
Actively Recruiting
120
US Oncology Investigational Products Center (IPC)
Irving, Texas, United States, 75063
Actively Recruiting
121
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care
Blacksburg, Virginia, United States, 24060
Actively Recruiting
122
Oncology & Hematology Associates of Southwest Virginia
Low Moor, Virginia, United States, 24457
Actively Recruiting
123
Oncology & Hematology Associates of Southwest Virginia Inc dba Blue Ridge Cancer Care
Roanoke, Virginia, United States, 24014
Actively Recruiting
124
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care
Salem, Virginia, United States, 24153
Actively Recruiting
125
Oncology & Hematology Associates of Southwest Virginia
Wytheville, Virginia, United States, 24382
Actively Recruiting
126
Providence Regional Cancer Partnership
Everett, Washington, United States, 98201
Actively Recruiting
127
Providence Regional Medical Center Everett
Everett, Washington, United States, 98201
Actively Recruiting
128
Northwest Cancer Specialists, P.C.
Vancouver, Washington, United States, 98684
Actively Recruiting
129
Centro de Investigacion Pergamino SA
Pergamino, Buenos Aires, Argentina, 2700
Actively Recruiting
130
Instituto Medico de la Fundacion Estudios Clinicos
Rosario, Santa Fe Province, Argentina, S2000DEJ
Actively Recruiting
131
Instituto Medico Especializado Alexander Fleming
Buenos Aires, Argentina, 1426
Actively Recruiting
132
Hospital Britanico de Buenos Aires
CABA, Argentina, 1280
Actively Recruiting
133
IONC Instituto Oncologico de Cordoba Fundacion Richardet Longo
Córdoba, Argentina, X5001 HWE
Actively Recruiting
134
CEMAIC - Centro Medico Privado
Córdoba, Argentina
Actively Recruiting
135
Chris O'Brien Lifehouse
Camperdown, New South Wales, Australia, 2050
Not Yet Recruiting
136
Princess Alexandra Hospital
Woolloongabba, Queensland, Australia, 4102
Actively Recruiting
137
St Vincent's Hospital
Fitzroy, Victoria, Australia, 3065
Actively Recruiting
138
Klinikum Wels-Grieskirchen GmbH Austria
Wels, Upper Austria, Austria, A-4600
Actively Recruiting
139
Landesapotheke Salzburg
Salzburg, Austria, 5020
Actively Recruiting
140
Uniklinikum Salzburg, Landeskrankenhaus
Salzburg, Austria, 5020
Actively Recruiting
141
AKH - Medizinische Universitat Wien
Vienna, Austria, 1090
Not Yet Recruiting
142
Klinikum Wels-Grieskirchen GmbH Austria
Wels, Austria, 4600
Actively Recruiting
143
Landesklinikum Wiener Neustadt
Wiener Neustadt, Austria, 2700
Not Yet Recruiting
144
Institut Jules Bordet
Anderlecht, Belgium, 1070
Actively Recruiting
145
Cliniques Universitaires Saint-Luc
Brussels, Belgium, 1200
Actively Recruiting
146
UZA
Edegem, Belgium, 2650
Actively Recruiting
147
CHU HELORA - Hopital de Jolimont
Haine-Saint-Paul, Belgium, 7100
Actively Recruiting
148
Universitair Ziekenhuis Leuven
Leuven, Belgium, 3000
Not Yet Recruiting
149
Centre Hospitalier Chretien - Clinique MontLegia
Liège, Belgium, 4000
Actively Recruiting
150
Maag-,Darm- en Leverziekten AZ Turnhout
Turnhout, Belgium, 2300
Actively Recruiting
151
Oncologisch Dagziekenhuis AZ Turnhout Campus Sint-Elisabeth
Turnhout, Belgium, 2300
Actively Recruiting
152
CIONC-Centro Integrado de Oncologia de Curitiba
Curitiba, Paraná, Brazil, 80810-050
Actively Recruiting
153
Instituto De Educação, Pesquisa e Gestão em Saúde - Instituto Américas
Barra da Tijuca, Rio de Janeiro, Brazil, 22.775-001
Actively Recruiting
154
Institute de Educacao, Pesquisa e Gestao em Saude - Instituto COI
Rio de Janeiro, Rio de Janeiro, Brazil, 22775-001
Actively Recruiting
155
Institute de Educacao, Pesquisa e Gestao em Saude - Instituto COI
Rio de Janeiro, Rio de Janeiro, Brazil, 22793-080
Actively Recruiting
156
Centro Integrado de Pesquisa em Oncologia CIPO-GHC / Hospital Nossa Senhora da Conceicao
Porto Alegre, Rio Grande do Sul, Brazil, 91350-200
Actively Recruiting
157
Hospital de Cancer de Barretos/Fundacao Pio XII
Barretos, São Paulo, Brazil, 14784-400
Actively Recruiting
158
Centro de Pesquisas Clinicas da Fundação Doutor Amaral Carvalho
Jaú, São Paulo, Brazil, 17210-120
Actively Recruiting
159
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia.
Santo André, São Paulo, Brazil, 09060-650
Actively Recruiting
160
Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto, São Paulo, Brazil, CEP 15090-000
Actively Recruiting
161
ICESP - Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira.
São Paulo, Brazil, 01245-000
Actively Recruiting
162
The Ottawa Hospital Cancer Centre
Ottawa, Ontario, Canada, K1H 8L6
Actively Recruiting
163
Sunnybrook Research Institute
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
164
Mount Sinai Hospital
Toronto, Ontario, Canada, M5G 1X5
Actively Recruiting
165
Jewish General Hospital
Montreal, Quebec, Canada, H3T 1E2
Actively Recruiting
166
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, Canada, S7N 4H4
Actively Recruiting
167
Oncocentro Apys
Viña del Mar, Valparaiso, Chile
Actively Recruiting
168
Biocenter
Concepción, Chile
Actively Recruiting
169
Centro de estudios clinicos SAGA
Santiago, Chile
Actively Recruiting
170
Fujian Medical University Union Hospital
Fuzhou, Fujian, China, 350001
Active, Not Recruiting
171
The 900th Hospital of The Chinese People's Liberation Army Joint Logistics Support Force
Fuzhou, Fujian, China, 350025
Terminated
172
The First Hospital of Lanzhou University
Lanzhou, Gansu, China, 730000
Active, Not Recruiting
173
The Sixth Affiliated hospital, Sun Yat-sen University
Guangzhou, Guangdong, China, 510655
Active, Not Recruiting
174
Meizhou People's hospital
Meizhou, Guangdong, China, 514031
Active, Not Recruiting
175
The Second Affiliated Hospital of Hainan Medical University
Haikou, Hainan, China, 570216
Active, Not Recruiting
176
Affiliated Hospital of Chengde Medical University
Chengde, Hebei, China, 067000
Active, Not Recruiting
177
Affiliated Hospital of Chengde Medical University
Chengde, Hebei, China, 067055
Active, Not Recruiting
178
Tangshan People's Hospital
Tangshan, Hebei, China, 063001
Active, Not Recruiting
179
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, China, 150081
Terminated
180
Nanyang Second General Hospital
Nanyang, Henan, China, 473009
Actively Recruiting
181
Henan Provincial People's Hospital
Zhengzhou, Henan, China, 450003
Active, Not Recruiting
182
Hubei Cancer Hospital
Wuhan, Hubei, China, 430000
Active, Not Recruiting
183
The Second Xiangya Hospital of Central South University
Changsha, Hunan, China, 410011
Terminated
184
The First People's Hospital of Changzhou
Changzhou, Jiangsu, China, 213003
Terminated
185
The First Affiliated Hospital of Suzhou University
Suzhou, Jiangsu, China, 215031
Active, Not Recruiting
186
Xuzhou Central Hospital
Xuzhou, Jiangsu, China, 221009
Terminated
187
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China, 330006
Active, Not Recruiting
188
The First Affiliated Hospital of Jinzhou Medical University
Jinzhou, Liaoning, China, 121001
Active, Not Recruiting
189
Liaoning Cancer Hospital & Institute
Shenyang, Liaoning, China, 110042
Active, Not Recruiting
190
Jinan Central Hospital
Jinan, Shandong, China, 250013
Active, Not Recruiting
191
Shandong Cancer Hospital
Jinan, Shandong, China, 250117
Active, Not Recruiting
192
LinYi Cancer Hospital
Linyi, Shandong, China, 276034
Terminated
193
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China, 200092
Terminated
194
Shanxi Province Cancer Hospital
Taiyuan, Shanxi, China, 030013
Terminated
195
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310009
Active, Not Recruiting
196
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310016
Active, Not Recruiting
197
Beijing Cancer Hospital
Beijing, China, 100142
Active, Not Recruiting
198
Hunan Cancer Hospital
Changsha, China, 410013
Active, Not Recruiting
199
Army Specialty Medical Center of The Chinese People's Liberation Army
Chongqing, China, 400042
Active, Not Recruiting
200
Shanghai General Hospital
Shanghai, China, 201620
Terminated
201
Centre Hospitalier Regional et Universitaire de Besancon - Hopital Jean-Minjoz
Besançon, Other, France, 25000
Actively Recruiting
202
Institut Sainte Catherine
Avignon, France, 84918
Actively Recruiting
203
CHU Brest Hopital Cavale Blanche
Brest, France, 29200
Actively Recruiting
204
CHU Estaing
Clermont-Ferrand, France, 63100
Actively Recruiting
205
Hopital Henri Mondor
Créteil, France, 94000
Actively Recruiting
206
Center Georges-Francois Leclerc
Dijon, France, 21079
Actively Recruiting
207
Hopital Edouard Herriot
Lyon, France, 69437
Actively Recruiting
208
Höpital Saint-Joseph
Marseille, France, 13285
Actively Recruiting
209
Centre Hospitalier Universitaire Nantes-Hotel Dieu
Nantes, France, 44093
Actively Recruiting
210
Centre Antoine Lacassagne
Nice, France, 06189
Actively Recruiting
211
Hopital Saint-Louis
Paris, France, 75010
Actively Recruiting
212
Pharmacy Address:Hopital Saint-Louis
Paris, France, 75010
Actively Recruiting
213
Hopital Saint-Antoine
Paris, France, 75012
Actively Recruiting
214
Hopital Europeen Georges Pompidou
Paris, France, 75015
Actively Recruiting
215
CHU Bordeaux Hopital Haut Leveque
Pessac, France, 33604
Not Yet Recruiting
216
CHU Poitiers
Poitiers, France, 86000
Actively Recruiting
217
CHU de Rouen
Rouen, France, 76031
Not Yet Recruiting
218
Institut de Cancérologie de l'Ouest - Saint-Herblain
Saint-Herblain, France, 44805 Cedex
Actively Recruiting
219
Centre Hospitalier Universitaire Sainte-Etienne - Hopital Nord
Saint-Priest-en-Jarez, France, 42270
Actively Recruiting
220
Institut de Cancerologie Strasbourg Europe
Strasbourg, France, 67033
Actively Recruiting
221
CHU Toulouse-Rangueil
Toulouse, France, 31059
Actively Recruiting
222
CCC Muenchen TUM
Munich, Bavaria, Germany, D-81675
Actively Recruiting
223
LMU Klinikum - Campus Großhadern
München, Bavaria, Germany, D-81377
Actively Recruiting
224
Medizinische Hochschule Hannover (MHH)
Hanover, Lower Saxony, Germany, 30625
Actively Recruiting
225
Universitätsklinikum Leipzig
Leipzig, Saxony, Germany, 04103
Actively Recruiting
226
Landesdirektion Sachsen Dienststelle Leipzig
Leipzig, Saxony, Germany, 04107
Actively Recruiting
227
Klinikum St. Marien Amberg
Amberg, Germany, 92224
Not Yet Recruiting
228
Charité - Universitätsmedizin Berlin
Berlin, Germany, 13353
Actively Recruiting
229
Klinikum Chemnitz gGmbH
Chemnitz, Germany, 09116
Actively Recruiting
230
Apotheke Johannstadt
Dresden, Germany, 01307
Actively Recruiting
231
Gemeinschaftspraxis Hämatologie - Onkologie
Dresden, Germany, 01307
Actively Recruiting
232
Technische Universität Dresden, Medizinische Fakultät Carl Gustav Carus
Dresden, Germany, 01307
Actively Recruiting
233
Universitätsklinikum Carl Gustav Carus Dresden
Dresden, Germany, 01307
Actively Recruiting
234
Hämatologisch Onkologische Praxis Eppendorf (HOPE)
Hamburg, Germany, 20249
Actively Recruiting
235
ZytoService Deutschland GmbH
Hamburg, Germany, 22045
Actively Recruiting
236
Asklepios Kliniken Hamburg GmbH
Hamburg, Germany, 22453
Actively Recruiting
237
Asklepios Tumorzentrum Hamburg, Asklepios Klinik Altona
Hamburg, Germany, 22763
Actively Recruiting
238
Medizinische Hochschule Hannover (MHH)
Hanover, Germany, 30625
Actively Recruiting
239
Universitätsklinikum Leipzig
Leipzig, Germany, 04103
Actively Recruiting
240
Klinikum rechts der Isar der Technischen Universitaet Muenchen
München, Germany, 81675
Actively Recruiting
241
Klinikum rechts der Isar der TU München, Krankenhausapotheke
München, Germany, 81675
Actively Recruiting
242
Universitaetsklinikum Ulm
Ulm, Germany, 89081
Actively Recruiting
243
Athens Medical Center - Psychikon branch
Athens, Attikí, Greece, 11525
Actively Recruiting
244
University General Hospital "Attikon"
Athens, Chaidari, Greece, 124 62
Not Yet Recruiting
245
"University General Hospital of Heraklion Oncology Unit "
Heraklion, Crete, Greece, 71500
Not Yet Recruiting
246
"Papageorgiou" General Hospital of Thessaloniki 2nd Internal Medicine/Oncology Clinic of Aristotle
Nea Efkarpia, Thessaloniki, Greece, 56403
Actively Recruiting
247
Evgenidion Clinic Agia Trias Oncology Department
Athens, Greece, 11528
Terminated
248
Cork University Hospital,Department of Medical Onncology
Cork, Ireland, T12 DC4A
Actively Recruiting
249
Bon Secours Hospital
Cork, Ireland, T12 DV56
Actively Recruiting
250
St Vincents University Hospital
Dublin, Ireland, D04 T6F4
Actively Recruiting
251
Mater Misericordiae University Hospital
Dublin, Ireland, D07 R2WY
Actively Recruiting
252
Mater Private Hospital
Dublin, Ireland, D07 WKW8
Actively Recruiting
253
Beaumont Hospital
Dublin, Ireland, D09 V2N0
Actively Recruiting
254
University Hospital Waterford
Waterford, Ireland, X91 ER8E
Actively Recruiting
255
Azienda Ospedaliera Universitaria Cagliari
Monserrato, Cagliari, Italy, 09042
Actively Recruiting
256
Farmacia AOU Cagliari - Presidio Ospedaliero ' Duilio Casula' di Monserrate
Monserrato, Cagliari, Italy, 09042
Actively Recruiting
257
UOC Oncologia Medica - Dipartimento Onco Ematologico AORN San Giuseppe Moscati di Avellino
Avellino, Campania, Italy, 83100
Actively Recruiting
258
IRCCS Ospedale Policlinico San Martino Farmacia
Genova, GE, Italy, 16132
Actively Recruiting
259
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rome, Lazio, Italy, 00168
Actively Recruiting
260
UOC Oncologia, Azienda Ospedaliera Cardinale Giovanni Panico
Tricase, Lecce, Italy, 73039
Actively Recruiting
261
Fondazione Poliambulanza Istituto Ospedaliero
Brescia, Lombardy, Italy, 25124
Actively Recruiting
262
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Lombardy, Italy, 20133
Actively Recruiting
263
lstituto Europeo di Oncologia
Milan, Lombardy, Italy, 20141
Actively Recruiting
264
Niguarda Cancer Center Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Milan, Lombardy, Italy, 20162
Actively Recruiting
265
UMaCA U.O.S.D. Farmacia Ospedaliera
Naples, Naples, Italy, 80131
Actively Recruiting
266
Ospedale S Chiara Farmacia
Pisa, Other, Italy, 56126
Actively Recruiting
267
Servizio Farmacia Azienda Ospedaliera Universitaria lntegrata (AOUI) di Verona
Verona, Other, Italy, 37134
Actively Recruiting
268
Farmacia Sperimentazioni
Reggio Emilia, RE, Italy, 42123
Actively Recruiting
269
UOC Oncologia Medica, ARNAS GARIBALDI - PRESIDIO OSPEDALIERO NESIMA
Catania, Sicily, Italy, 95122
Actively Recruiting
270
A.O.U. San Luigi Gonzaga
Orbassano, Turin, Italy, 10043
Actively Recruiting
271
SODc Oncologia Medica e Clinica, AOU Careggi
Florence, Tuscany, Italy, 50134
Actively Recruiting
272
Azienda Ospedaliero Universitaria Pisana
Pisa, Tuscany, Italy, 56126
Actively Recruiting
273
Istituto Oncologico Veneto - IRCCS
Padova, Veneto, Italy, 35128
Actively Recruiting
274
Struttura Semplice Dipartimentale di Oncologia Medica e Terapia Biomolecolare Azienda Ospedaliero
Foggia, Italy, 71122
Actively Recruiting
275
IRCCS Azienda Ospedaliera Metropolitana (IRCCS AOM)
Genova, Italy, 16132
Actively Recruiting
276
lstituto Europeo di Oncologia Servizio Farmacia
Milan, Italy, 20141
Actively Recruiting
277
Fondazione IRCCS Istituto Nazionale dei Tumori Farmacia
Milan, Italy, 20133
Actively Recruiting
278
Istituto Oncologico Veneto-IRCCS Farmacia
Padova, Italy, 35128
Actively Recruiting
279
Fondazione IRCCS Policlinico San Matteo Farmacia
Pavia, Italy, 27100
Actively Recruiting
280
Fondazione IRCCS Policlinico San Matteo
Pavia, Italy, 27100
Actively Recruiting
281
Farmacia UFA
Reggio Emilia, Italy, 42123
Actively Recruiting
282
S.C Oncologia Arcispedale Santa Maria Nuova
Reggio Emilia, Italy, 42123
Actively Recruiting
283
Farmacia degli Sperimentali Policlinico Gemelli IRCCS
Roma, Italy, 00168
Actively Recruiting
284
ASST della Valtellina e dell'alto Lario - Presidio Ospedaliero di Sondrio
Sondrio, Italy, 23100
Actively Recruiting
285
ASST della Valtellina e dell'alto Lario- Presidio Ospedaliero di Sondrio Farmacia
Sondrio, Italy, 23100
Actively Recruiting
286
U.O.C. Oncologia Azienda Ospedaliera Universitaria lntegrata (AOUI) di Verona
Verona, Italy, 37134
Actively Recruiting
287
Chiba Cancer Center
Chiba, Chiba, Japan, 260-8717
Actively Recruiting
288
National Cancer Center Hospital East
Kashiwa-shi, Chiba, Japan, 277-8577
Actively Recruiting
289
NHO Shikoku Cancer Center
Matsuyama, Ehime, Japan, 791-0280
Active, Not Recruiting
290
National Hospital Organization Kyushu Cancer Center
Fukuoka, Fukuoka, Japan, 811-1395
Actively Recruiting
291
Hokkaido University Hospital
Sapporo, Hokkaido, Japan, 060-8648
Actively Recruiting
292
Kobe City Hospital Organization Kobe City Medical Center General Hospital
Kobe, Hyōgo, Japan, 650-0047
Actively Recruiting
293
Kagawa University Hospital
Kita-gun, Kagawa-ken, Japan, 761-0793
Actively Recruiting
294
St. Marianna University Hospital
Kawasaki-shi, Kanagawa, Japan, 216-8511
Actively Recruiting
295
Kanagawa Cancer Center
Yokohama, Kanagawa, Japan, 241-8515
Actively Recruiting
296
Osaka General Medical Center
Osaka, Osaka, Japan, 558-8558
Actively Recruiting
297
Kindai University Hospital
Osakasayama-shi, Osaka, Japan, 589-8511
Actively Recruiting
298
Kindai University Hospital
Sakai, Osaka, Japan, 590-0197
Actively Recruiting
299
Osaka University Hospital
Suita-shi, Osaka, Japan, 565-0871
Actively Recruiting
300
Osaka Medical and Pharmaceutical University Hospital
Takatsuki-shi, Osaka, Japan, 569-8686
Actively Recruiting
301
Saitama Cancer Center
Kitaadachi-gun, Saitama, Japan, 362-0806
Actively Recruiting
302
National Cancer Center Hospital
Chuo-Ku, Tokyo, Japan, 104-0045
Actively Recruiting
303
Cancer Institute Hospital of JFCR
Koto-ku, Tokyo, Japan, 135-8550
Actively Recruiting
304
National Hospital Organization Osaka National Hospital
Osaka, Japan, 540-0006
Actively Recruiting
305
St. Antonius Hospital
Nieuwegein, Other, Netherlands, 3435 CM
Actively Recruiting
306
Netherlands Cancer Institute
Amsterdam, Netherlands, 1066 CX
Actively Recruiting
307
Klinische Farmacie
Nieuwegein, Netherlands, 3534 CM
Actively Recruiting
308
St. Antonius Ziekenhuis - Ziekenhuis Utrecht
Utrecht, Netherlands, 3543 AZ
Actively Recruiting
309
Viecuri Medisch Centrum
Venlo, Netherlands, 5912 BL
Actively Recruiting
310
Sjukehusapoteket i Bergen [Bergen Hospital Pharmacy]
Bergen, Norway, N0-5053
Actively Recruiting
311
Helse Bergen HF, Haukeland University Hospital
Bergen, Norway, NO-5021
Actively Recruiting
312
Oslo University Hospital (OUH) - The Norwegian Radium Hospital
Oslo, Norway, 0379
Actively Recruiting
313
Przychodnia Lekarska KOMED Roman Karaszewski
Konin, Greater Poland Voivodeship, Poland, 62-500
Actively Recruiting
314
Narodowy lnstytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy lnstytut Badawczy
Warsaw, Masovian Voivodeship, Poland, 02-034
Actively Recruiting
315
Marii Sklodowskiej-Curie Panstwowy lnstytut Badawczy
Warsaw, Masovian Voivodeship, Poland, 02-781
Actively Recruiting
316
Wojskowy Instytut Medyczny Klinika Onkologii
Warsaw, Masovian Voivodeship, Poland, 04-141
Not Yet Recruiting
317
Wojskowy Instytut Medyczny
Warsaw, Masovian Voivodeship, Poland, 04-141
Not Yet Recruiting
318
MRUK-MED | Sp. z.o.o Apteka szpitalna
Rzeszów, Podkarpackie Voivodeship, Poland, 35-021
Not Yet Recruiting
319
MRUK-MED | Sp. z.o.o
Rzeszów, Podkarpackie Voivodeship, Poland, 35-021
Not Yet Recruiting
320
Apteka Szpitalna Uniwersytie Centrum Kliniczne
Gdansk, Pomeranian Voivodeship, Poland, 80-214
Actively Recruiting
321
Salve Medica Apteka Szpitalna
Lodz, Poland, 91-211
Actively Recruiting
322
Hospital Garcia de Orta
Almada, Portugal, 2805-267
Actively Recruiting
323
Unidade Local de Saude da Guarda-Hospital Sousa Martins
Guarda, Portugal, 6300-035
Actively Recruiting
324
Fundacao Champalimaud
Lisbon, Portugal, 1400-038
Actively Recruiting
325
Centro Hospitalar Universitário de Santo Antonio,E.P.E.
Porto, Portugal, 4099-001
Actively Recruiting
326
Narodny Onkologicky ustav II.Onkologicka Klinika LFUK a NOU
Bratislava, Slovakia, 833 10
Actively Recruiting
327
Gachon University Gil Medical Center
Incheon, South Korea, 21565
Actively Recruiting
328
Korea University Anam Hospital
Seoul, South Korea, 02841
Actively Recruiting
329
Seoul National University Hospital
Seoul, South Korea, 03080
Actively Recruiting
330
Severance Hospital, Yonsei University Health System
Seoul, South Korea, 03722
Actively Recruiting
331
Asan Medical Center
Seoul, South Korea, 05505
Actively Recruiting
332
Samsung Medical Center
Seoul, South Korea, 06351
Actively Recruiting
333
Korea University Guro Hospital
Seoul, South Korea, 08308
Actively Recruiting
334
Hospital Duran i Reynals - Institut Catala d'Oncologia L'Hospitalet (ICO L'Hospitalet)
L'Hospitalet de Llobregat, Barcelona, Spain, 08908
Actively Recruiting
335
Clinica Universidad de Navarra
Pamplona, Navarre, Spain, 31008
Actively Recruiting
336
CETIR Viladomat
Barcelona, Other, Spain, 08029
Actively Recruiting
337
Complejo Hospitalario Universitario de Canarias
San Cristóbal de La Laguna, Santa CRUZ DE Tenerife, Spain, 38320
Actively Recruiting
338
Hospital General Universitario de Alicante
Alicante, Spain, 03010
Actively Recruiting
339
Radiology: CETIR Ascires
Barcelona, Spain, 08029
Actively Recruiting
340
Data review: Vall d'Hebron institute of Oncology (VHIO).
Barcelona, Spain, 08035
Actively Recruiting
341
Hospital Vall d'Hebron Unidad de Farmacia de Ensayos Clinicos Oncohematologia
Barcelona, Spain, 08035
Actively Recruiting
342
Hospital Vall d'Hebron
Barcelona, Spain, 08035
Actively Recruiting
343
Hospital Clinic de Barcelona
Barcelona, Spain, 08036
Actively Recruiting
344
Hospital Universitario Reina Sofia
Córdoba, Spain, 14004
Actively Recruiting
345
Hospital Universitari Arnau de Vilanova
Lleida, Spain, 25198
Actively Recruiting
346
Hospital General Universitario Gregorio Maranon
Madrid, Spain, 28007
Actively Recruiting
347
Clínica Universidad de Navarra (Madrid)
Madrid, Spain, 28027
Actively Recruiting
348
Hospital Universitario Ramon y Cajal
Madrid, Spain, 28034
Actively Recruiting
349
Hospital Universitario 12 de Octubre
Madrid, Spain, 28041
Actively Recruiting
350
Hospital Universitario La Paz
Madrid, Spain, 28046
Actively Recruiting
351
Hospital Regional Universitario de Malaga (Hospital Civil)
Málaga, Spain, 29011
Actively Recruiting
352
Complejo Hospitalario Universitario de Ourense
Ourense, Spain, 32005,
Actively Recruiting
353
Hospital Universitario Central de Asturias
Oviedo, Spain, 33011
Actively Recruiting
354
Complejo Hospitalario de Navarra
Pamplona, Spain, 31008
Actively Recruiting
355
Hospital Universitario Marques de Valdecilla
Santander, Spain, 39008
Actively Recruiting
356
Hospital Universitario Virgen del Rocio
Seville, Spain, 41013
Active, Not Recruiting
357
Hospital General Universitario de Valencia
Valencia, Spain, 46014
Actively Recruiting
358
Hospital Quiron Salud Zaragoza
Zaragoza, Spain, 50006
Actively Recruiting
359
Hospital Universitario Miguel Servet
Zaragoza, Spain, 50009
Actively Recruiting
360
Pharmacy:Kantonsspital Winterthur
Winterthur, Other, Switzerland, 8401
Actively Recruiting
361
Zuripharm AG
Schlieren, Switzerland, 8952
Actively Recruiting
362
Kantonsspital Winterthur
Winterthur, Switzerland, 8401
Actively Recruiting
363
Universitatsspital Zurich - Klinik fur Medizinische Onkologie und Hamatologie USZ
Zurich, Switzerland, 8091
Actively Recruiting
364
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Taiwan, 833, (R.O.C.)
Actively Recruiting
365
National Cheng Kung University Hospital
Tainan, Taiwan, 704, R.O.C.
Actively Recruiting
366
National Taiwan University Hospital
Taipei, Taiwan, 100 ROC
Actively Recruiting
367
National Taiwan University Hospital Clinical Trial Pharmacy
Taipei, Taiwan, 10048
Actively Recruiting
368
Taipei Veterans General Hospital
Taipei, Taiwan, 11217
Actively Recruiting
369
Chang Gung Memorial Hospital LinKou
Taoyuan, Taiwan, 333 (R.O.C.)
Actively Recruiting
370
The Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne, Chelsea, United Kingdom, NE7 7DN
Actively Recruiting
371
The Royal Marsden Hospital
Sutton, Surrey, United Kingdom, SM2 5PT
Actively Recruiting
372
University Hospitals Bristol and Weston NHS Foundation Trust
Bristol, United Kingdom, BS2 8ED
Actively Recruiting
373
Cambridge University Hospitals NHS Foundation Trust, Oncology Centre
Cambridge, United Kingdom, CB2 0QQ
Actively Recruiting
374
The Beatson West of Scotland Cancer Centre
Glasgow, United Kingdom, G12 OYN
Actively Recruiting
375
Leeds Teaching Hospitals NHS Trust, st James's Institute of Oncology
Leeds, United Kingdom, LS97TF
Actively Recruiting
376
Guy's and Saint Thomas' NHS Foundation Trust
London, United Kingdom, SE1 9RT
Actively Recruiting
377
The Royal Marsden Hospital - Chelsea Site
London, United Kingdom, SW3 6JJ
Actively Recruiting
378
The Royal Marsden NHS Foundation Trust
London, United Kingdom, SW3 6JJ
Actively Recruiting
379
Imperial College Healthcare NHS Trust
London, United Kingdom, W12 0NN
Actively Recruiting
380
The Christie NHS Foundation Trust
Manchester, United Kingdom, M20 4BX
Actively Recruiting
381
The Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne, United Kingdom, NE7 7DN
Actively Recruiting
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Research Team
P
Pfizer CT.gov Call Center
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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