Actively Recruiting
A Study of TYRA-300 in Children With Achondroplasia: BEACH301
Led by Tyra Biosciences, Inc · Updated on 2026-04-24
92
Participants Needed
15
Research Sites
273 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the safety, tolerability, and identify potentially effective dose(s) of TYRA-300 in children with achondroplasia with open growth plates.
CONDITIONS
Official Title
A Study of TYRA-300 in Children With Achondroplasia: BEACH301
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 3 to 10 years old (inclusive) at the time of consent
- Informed consent provided by parent(s) or legal guardian(s); participants able to provide written assent if applicable
- Molecular diagnosis of achondroplasia (FGFR3 G380R)
- Radiographically confirmed open growth plates at screening
- Able to stand and walk independently
- Able to take oral medication
- Sentinel Safety Cohort only: aged 5 to 10 years old (inclusive)
- Cohort 1 only: aged 3 to 10 years old and naive to prior growth accelerating therapy
- Cohort 2 only: aged 3 to 10 years old and have received prior growth accelerating therapy
You will not qualify if you...
- Any concurrent disease or condition interfering with study participation or safety evaluations
- Uncontrolled or untreated condition affecting pediatric growth
- Diagnosis of endocrine condition altering calcium/phosphate balance
- Prior limb lengthening surgery or plans to have surgery during the study
- Use of strong inhibitors or inducers of cytochrome P450 3A4
- History or current corneal, retinal disorder, or keratopathy
- Presence of guided growth hardware/8 plates or planned orthopedic surgeries
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 15 locations
1
Lundquist Institute for Biomedical Innovation
Torrance, California, United States, 90502
Actively Recruiting
2
Children's Hospital Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
3
Nemours Alfred I duPont Hospital for Children
Wilmington, Delaware, United States, 19803
Actively Recruiting
4
Johns Hopkins University School of Medicine
Baltimore, Maryland, United States, 21205
Actively Recruiting
5
Uncommon Cures
Chevy Chase, Maryland, United States, 20815
Actively Recruiting
6
University of Missouri
Columbia, Missouri, United States, 65201
Actively Recruiting
7
Washington University
St Louis, Missouri, United States, 63130
Actively Recruiting
8
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
9
Children's Medical Center, Dallas
Dallas, Texas, United States, 75235
Actively Recruiting
10
University of Texas Health Science Center Medical School at Houston
Houston, Texas, United States, 77030
Actively Recruiting
11
University of Wisconsin-Madison
Madison, Wisconsin, United States, 53715
Actively Recruiting
12
The Children's Hospital at Westmead
Westmead, New South Wales, Australia, 2145
Actively Recruiting
13
Royal Children's Hospital
Parkville, Victoria, Australia, 3052
Actively Recruiting
14
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G1X8
Actively Recruiting
15
Unidad de Cirugía Artroscópica (MIKS Hospital)
Vitoria-Gasteiz, Alava, Spain, 1008
Actively Recruiting
Research Team
S
Sinette Heys
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
4
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