Actively Recruiting
A Study of Ultra-fraction Radiotherapy Bridging CART in R/R DLBCL
Led by Peking Union Medical College Hospital · Updated on 2026-03-24
20
Participants Needed
1
Research Sites
326 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a single-arm single center study to prospectively evaluate the safety and efficacy of ultra-fraction radiotherapy bridging CAR-T therapy in relapsed/refractory diffuse large b cell lymphoma
CONDITIONS
Official Title
A Study of Ultra-fraction Radiotherapy Bridging CART in R/R DLBCL
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Over 18 years old
- Histologically confirmed diffuse large B cell lymphoma
- Relapsed or refractory disease after at least 2 lines of chemotherapy including rituximab and anthracycline
- Failed autologous hematopoietic stem cell transplantation or ineligible/not consenting to it
- Measurable disease with tumor size of 1.5 cm or greater
- Life expectancy of at least 12 weeks
- Able to receive radiotherapy as evaluated by a specialist
You will not qualify if you...
- Prior radiation therapy within 1 year of infusion
- Pregnant or nursing (lactating) women
- Uncontrolled acute life-threatening bacterial, viral, or fungal infection
- Previous solid tumor within 3 years or previous/concurrent hematological malignancy
- Severe organ dysfunction including LVEF less than 40%, DLCO less than 40%, eGFR less than 30 mL/min/1.73 m2, or total bilirubin over 3 times the upper limit of normal
- HIV positive, active or prior hepatitis B infection, or active hepatitis C infection
- Other conditions that the investigator deems risky or unsuitable for participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China, 100730
Actively Recruiting
Research Team
J
Jing Ruan, Docter
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here