Actively Recruiting
Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease
Led by National Human Genome Research Institute (NHGRI) · Updated on 2026-01-14
50
Participants Needed
1
Research Sites
250 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this research study is to look at genes and determine how they interact with each other to find changes that could explain why some people's immune systems may respond to blood transfusions. This response is called an alloimmune response. We strongly believe that when someone has an alloimmune response, it is caused by changes in their genes. We plan to compare changes in the genes of individuals that develop red blood cell alloimmunization after blood transfusions with those that do not develop alloimmunization. This may help us to create more targeted therapeutic interventions, which may improve the health of alloimmune responders.
CONDITIONS
Official Title
Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant is older than 2 years
- Confirmed diagnosis of sickle cell disease
- Meets at least one of the following: history of more than ten transfusions or 20 transfusion units, history of one or more antibody screens, or known candidate variant genotype
You will not qualify if you...
- Impaired decision-making ability, with or without a legally authorized representative
- History of transplant such as organ, bone marrow, or stem cell transplant
- Taking immunosuppressive medications at the time of enrollment
- Confirmed pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
E
Emilyn C Banfield
CONTACT
N
Neil A Hanchard, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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