Understanding Acute Kidney Injury Development After Heart Surgery with Heart-Lung Machine Use

What this Trial Is About

Researchers are investigating how cardiac surgery-associated acute kidney injury CSA-AKI develops in people undergoing heart surgeries that use a heart-lung machine. CSA-AKI is a common complication where the kidneys stop working properly, especially in older adults or those with kidney disease and diabetes. The study focuses on understanding the biological processes and biomarkers involved in CSA-AKI during the early hours and days after surgery. Participants in this study will undergo scheduled heart surgeries involving cardiopulmonary bypass as part of their normal medical treatment. The study does not involve any investigational treatments. Instead, blood and urine samples will be collected before and after surgery for biomarker analysis, while patients receive standard care. The study aims to compare these biomarkers between those who develop CSA-AKI within a week after surgery and those who do not. During the study, which lasts up to 2 months per participant, researchers will collect blood and urine samples, review medical records and test reports during hospitalization, and monitor participants overall health. The primary outcome measured is the number of participants developing CSA-AKI within 3 days post-surgery. Secondary outcomes include changes in biomarkers up to 7 days after surgery. This monitoring and data collection will help understand CSA-AKI better and guide future prevention strategies.

A Study to Understand How Cardiac Surgery-associated Acute Kidney Injury Develops in Participants Who Undergo Heart Surgery With the Use of Heart-lung Machine