Study to Investigate How Acute Kidney Injury Develops After Heart Surgery Using Heart-Lung Machine

What This Trial Is About

Researchers are investigating cardiac surgery-associated acute kidney injury CSA-AKI, a frequent complication where the kidneys malfunction after heart surgeries involving a heart-lung machine. The study focuses on understanding how CSA-AKI develops, especially in the early hours and days post-surgery, by examining certain biological markers biomarkers that may signal this condition. The aim is to better understand CSA-AKI mechanisms and identify potential targets for prevention or treatment. Participants scheduled for heart surgeries using cardiopulmonary bypass will be observed without receiving any experimental treatments. Blood and urine samples will be collected before and after surgery for biomarker analysis. The study involves participants receiving their usual medical care during and after surgery, with no investigational interventions administered. Throughout the study, which lasts up to two months per participant, researchers will collect blood and urine samples, review medical records and test results from hospitalization, and monitor overall health. The primary outcome is the number of participants developing CSA-AKI within three days after surgery. Secondary outcomes include changes and levels of specific biomarkers up to seven days post-surgery, helping to understand the relationship between these markers and CSA-AKI occurrence.

A Study to Understand How Cardiac Surgery-associated Acute Kidney Injury Develops in Participants Who Undergo Heart Surgery With the Use of Heart-lung Machine