Actively Recruiting
A Study to Understand How a Study Medicine Called PF-07328948 is Absorbed and Processed in the Body of Healthy Male Adults
Led by Pfizer · Updated on 2026-05-05
8
Participants Needed
1
Research Sites
24 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to learn how a certain amount of \[14C\] PF-07320948 is taken up into the bloodstream and removed from the body. This study is seeking participants who are: * Male between 18 to 64 years of age * Deemed to be healthy This is a 2 Part, 4 Period study where Part 1 has Periods 1 and 2 and Part 2, which is optional, has Periods 3 and 4. Part 1 * Period 1: The purpose is to see how much of the study medicine PF-07328948 gets into and leaves the body. * Period 2: The goal is to compare how much PF-07328948 is available in the body when taken by mouth versus by injection into the blood. Part 2 (Optional) * Period 3 (optional): If needed, the purpose is to see how PF-07328948 acts after taking it daily until the body reaches a steady level. * In Period 4 (optional), the goal is to check again how much PF-07328948 is absorbed and leaves the body after daily dosing. During study clinic stays and study visits, the study team will collect urine and blood samples and perform safety reviews. If only Part 1 is conducted, total time in the study (screening (start) through follow-up (end)) will be about 14 weeks. If both Part 1 and Part 2 are conducted, total time in the study will be about 22 weeks.
CONDITIONS
Official Title
A Study to Understand How a Study Medicine Called PF-07328948 is Absorbed and Processed in the Body of Healthy Male Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male participants aged 18 years to under 65 years at screening who are healthy based on medical evaluation including history, physical exam, labs, and ECGs
- Body mass index (BMI) between 17.5 and 32 kg/m2
- Body weight greater than 50 kg (110 lb)
You will not qualify if you...
- History or evidence of significant blood, kidney, hormone, lung, digestive, heart, liver, psychiatric, neurological, or allergy-related diseases
- Use of investigational drugs or vaccines within 30 days or 5 half-lives before first study dose or participation in other investigational studies during this study
- Elevated background radioactivity in plasma or urine above specified limits at screening
- Participation in a radiolabeled absorption, distribution, metabolism, and excretion (ADME) study within 12 months before screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fortrea Clinical Research Unit Inc.
Madison, Wisconsin, United States, 53704
Actively Recruiting
Research Team
P
Pfizer CT.gov Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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