Actively Recruiting
A Study Using Subject-specific MRD to Adopt Treatment After HSCT for Subjects With MDS
Led by Karolinska University Hospital · Updated on 2023-12-05
200
Participants Needed
1
Research Sites
210 weeks
Total Duration
On this page
Sponsors
K
Karolinska University Hospital
Lead Sponsor
N
Nordic MDS Group
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this interventional study is to evaluate if pre-emptive intervention using Azacitidine and / or donor lymphocytes or tapering of immune suppression in measurable residual disease (MRD) positive subjects can prevent clinical relapse. Participants will undergo MRD surveillance and be subjected to intervention in case of MRD positivity. Results will be compared with NMDSG14B, part one, in which MRD was analyzed in included patients without recieving intervention.
CONDITIONS
Official Title
A Study Using Subject-specific MRD to Adopt Treatment After HSCT for Subjects With MDS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent
- Age 18 years or older
- Eligible for stem cell transplantation
- Diagnosed with MDS, mixed myelodysplastic/myeloproliferative syndrome, or AML with myelodysplasia-related dysplasia and 20-29% marrow blasts
- Female participants of childbearing potential must have a negative pregnancy test within 2 weeks before joining the study
You will not qualify if you...
- No detectable genetic abnormality found in screening or diagnostic genetic testing
- Uncontrolled hypertension, heart, liver, kidney, or other serious medical or psychiatric conditions
- Mental inability, reluctance, or language difficulties preventing understanding of the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Hematology, Karolinska University Hospital
Stockholm, Sweden
Actively Recruiting
Research Team
M
Magnus Tobiasson, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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