Actively Recruiting
Study of A Venetoclax-based, Anthracycline-free Regimen in Newly Diagnosed CBFβ::MYH11(+) AML
Led by The First Affiliated Hospital of Soochow University · Updated on 2025-09-04
40
Participants Needed
2
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This investigator-initiated, single-arm, phase II trial is aimed to evaluate the efficacy and safety of a venetoclax-based, anthracycline-free regimen in patients with newly diagnosed CBFβ::MYH11-positive acute myeloid leukemia.
CONDITIONS
Official Title
Study of A Venetoclax-based, Anthracycline-free Regimen in Newly Diagnosed CBFβ::MYH11(+) AML
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years or older
- Newly diagnosed with CBFβ::MYH11-positive acute myeloid leukemia
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 3
- Voluntarily signed informed consent prior to any study procedures
- Patients deemed unfit for intensive chemotherapy if meeting any Ferrara criteria: age over 75 years; serious heart, lung, kidney, or liver complications; active infections unresponsive to treatment; cognitive impairment; or other comorbidities deemed unsuitable by doctor
You will not qualify if you...
- Previous treatment with hypomethylating agents, chemotherapy, or targeted drugs for AML (except oral hydroxyurea or leukocytometry)
- Pregnant or breastfeeding women
- Inability to complete all study visits or procedures, including follow-up
- Other conditions considered unsuitable for participation by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Ethical Committee of the First Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China, 215000
Actively Recruiting
2
The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology
Suzhou, Jiangsu, China, 215000
Actively Recruiting
Research Team
Y
Ying Wang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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