Actively Recruiting

Phase 2
Age: 15Years +
All Genders
NCT05376111

Study of Venetoclax Combined With Azacitidine Regimen in Newly Diagnosed T-ALL Patients

Led by The First Affiliated Hospital of Soochow University · Updated on 2026-03-19

28

Participants Needed

1

Research Sites

243 weeks

Total Duration

On this page

Sponsors

T

The First Affiliated Hospital of Soochow University

Lead Sponsor

J

Jining Medical University

Collaborating Sponsor

AI-Summary

What this Trial Is About

The purpose of this study is to evaluate the efficacy and safety of venetoclax combined with azacitidine regimen for newly diagnosed T-ALL patients.

CONDITIONS

Official Title

Study of Venetoclax Combined With Azacitidine Regimen in Newly Diagnosed T-ALL Patients

Who Can Participate

Age: 15Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients aged 215.
  • Diagnosed with T-cell acute lymphoblastic leukemia based on 2016 WHO precursor lymphoid neoplasm criteria.
  • ECOG performance status less than 3.
  • No serious heart, lung, liver, or kidney dysfunction.
  • Able to understand and provide informed consent voluntarily.
Not Eligible

You will not qualify if you...

  • Allergy to the study drug or similar chemical structures.
  • Pregnant or breastfeeding women, or women of childbearing potential not using effective contraception.
  • Uncontrolled active infection.
  • Active bleeding.
  • New thrombosis, embolism, cerebral hemorrhage, or related conditions within one year before enrollment.
  • Mental disorders or conditions preventing informed consent or study compliance.
  • Significant liver dysfunction or renal anomalies as defined by lab values.
  • History of significant heart issues including QTc prolongation, tachycardia, atrial fibrillation, heart block, myocardial infarction within one year, congestive heart failure, or symptomatic coronary heart disease.
  • Surgery on major organs within six weeks prior.
  • Drug or long-term alcohol abuse affecting evaluation.
  • Previous chemotherapy treatments related to the disease.

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 1 location

1

The First Affliated Hospital of Soochow University

Suzhou, Jiangsu, China, 215006

Actively Recruiting

Loading map...

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here