Actively Recruiting
A Study of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation
Led by Mayo Clinic · Updated on 2026-05-01
228
Participants Needed
3
Research Sites
258 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this research study is to compare the technique of performing bilateral lung transplantation off-pump vs venoarterial ECMO (VA ECMO). The goal of the trial is to determine which technique has lower rates of primary graft dysfunction.
CONDITIONS
Official Title
A Study of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Bilateral lung transplantation recipients
- Mean pulmonary artery pressure less than or equal to 35 mmHg
- Eligible for off-pump or VA ECMO based on the attending surgeon's judgment
You will not qualify if you...
- Single lung transplant
- Multiorgan transplant
- Donor after cardiac death (DCD)
- Re-transplant
- Intention to use prophylactic post-operative ECMO
- Previous major lung surgery (excluding VATS and wedge resection)
- Previous pleurodesis
- Preoperative ECMO and/or mechanical ventilation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
University Of Louisville
Louisville, Kentucky, United States, 40202
Actively Recruiting
2
Mayo Clinic Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
3
Baylor College of Medicine
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
M
Mauricio Villavicencio, MD, MBA
CONTACT
J
Jackie Reiter
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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