Actively Recruiting
A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease
Led by Verve Therapeutics, Inc. · Updated on 2026-04-01
85
Participants Needed
22
Research Sites
169 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
VT-10201 is an Open-label, Phase 1b, Single-ascending Dose Study That Will Evaluate the Safety of VERVE-102 Administered to Patients With Heterozygous Familial Hypercholesterolemia (HeFH) or Premature Coronary Artery Disease (CAD) Who Require Additional Lowering of LDL-C. VERVE-102 Uses Base-editing Technology Designed to Disrupt the Expression of the PCSK9 Gene in the Liver and Lower Circulating PCSK9 and LDL-C. This Study is Designed to Determine the Safety and Pharmacodynamic Profile of VERVE-102 in This Patient Population.
CONDITIONS
Official Title
A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of heterozygous familial hypercholesterolemia or premature coronary artery disease
You will not qualify if you...
- Diagnosis of homozygous familial hypercholesterolemia
- Active or history of chronic liver disease
- Current or recent treatment with PCSK9 inhibitor
- Clinically significant or abnormal laboratory values as defined by the protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 22 locations
1
Clinical Study Center
Dothan, Alabama, United States, 36305
Actively Recruiting
2
Clinical Study Center
Pomona, California, United States, 91768
Actively Recruiting
3
Clinical Study Center
Boca Raton, Florida, United States, 33434
Actively Recruiting
4
Clinical Study Center
Jacksonville, Florida, United States, 32216
Actively Recruiting
5
Clinical Study Center
Winter Park, Florida, United States, 32789
Actively Recruiting
6
Clinical Study Center
High Point, North Carolina, United States, 27260
Actively Recruiting
7
Clinical Study Center
DeSoto, Texas, United States, 75115
Actively Recruiting
8
Clinical Study Center
Renton, Washington, United States, 98057
Actively Recruiting
9
Clinical Study Center
Adelaide, Australia
Actively Recruiting
10
Clinical Study Center
Melbourne, Australia
Actively Recruiting
11
Clinical Study Center
Sydney, Australia
Active, Not Recruiting
12
Clinical Study Center
Chicoutimi, Canada
Actively Recruiting
13
Clinical Study Center
Montreal, Canada
Actively Recruiting
14
Clinical Study Center
Toronto, Canada
Actively Recruiting
15
Clinical Study Center
Vancouver, Canada
Actively Recruiting
16
Clinical Study Center
Rehovot, Israel
Actively Recruiting
17
Clinical Study Center
Christchurch, New Zealand
Actively Recruiting
18
Clinical Study Center
Birmingham, United Kingdom
Actively Recruiting
19
Clinical Study Center
Edinburgh, United Kingdom
Actively Recruiting
20
Clinical Study Center
London, United Kingdom
Actively Recruiting
21
Clinical Study Center
Manchester, United Kingdom
Actively Recruiting
22
Clinical Study Center
Nottingham, United Kingdom
Actively Recruiting
Research Team
C
Clinical Development
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
10
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