Actively Recruiting
Study of VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease (VIVID)
Led by Vega Therapeutics, Inc · Updated on 2025-08-26
116
Participants Needed
25
Research Sites
350 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The VIVID study is structured in a master protocol format comprised of multiple parts that evaluate intravenous (IV) and subcutaneous (SC) VGA039 in healthy volunteers and subjects with von Willebrand Disease (VWD) and other bleeding disorders.
CONDITIONS
Official Title
Study of VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease (VIVID)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 60 years for Parts 1 and 2
- Age 12 to 60 years for Parts 3 and 5
- No clinically significant abnormal laboratory results, ECG, or vital signs
- Body mass index between 18 and 32 kg/m2 (Part 1 only)
- For Part 2, subjects must have symptomatic von Willebrand Disease with a history of bleeding or bruising
- Hemoglobin level of at least 8 g/dL and platelet count of at least 150 x 10^9/L at screening (Part 2 only)
You will not qualify if you...
- Use of hormonal contraceptives within 56 days before study drug administration
- Detection of certain blood clotting mutations or deficiencies at screening, including FV Leiden, Prothrombin G20210A mutation, protein C or S deficiency, antithrombin deficiency, or antiphospholipid antibody syndrome
- Known pro-thrombotic disorders or abnormal thrombophilia lab results
- History of arterial or venous thrombosis, including superficial thrombophlebitis or embolism
- Kidney, liver, nervous system, respiratory, heart, brain, blood vessel, or metabolic diseases
- Baseline factor VIII activity greater than 150 IU/dL (Part 1 only)
- Baseline factor VIII activity greater than 50 IU/dL (Parts 2, 3, 4, and 5)
- Any acute bleeding event needing surgical or procedural intervention within 7 days before receiving study drug (Parts 2, 3, 4, and 5)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 25 locations
1
Orthopedic Institute for Children (UCLA)
Los Angeles, California, United States, 90007
Actively Recruiting
2
UC Davis Medical Center
Sacramento, California, United States, 95817
Actively Recruiting
3
University of Colorado School of Medicine
Aurora, Colorado, United States, 80045
Actively Recruiting
4
Hemophilia of Georgia Center for Bleeding & Clotting Disorders of Emory
Atlanta, Georgia, United States, 30308
Actively Recruiting
5
Science 37, Inc.
Morrisville, North Carolina, United States, 27560
Actively Recruiting
6
Hemophilia Center of Western PA
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
7
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
8
University of Texas Southwestern
Dallas, Texas, United States, 75235
Actively Recruiting
9
Washington Center for Bleeding Disorders
Seattle, Washington, United States, 98101
Actively Recruiting
10
Versiti Comprehensive Center for Bleeding Disorders
Milwaukee, Wisconsin, United States, 53233
Actively Recruiting
11
Royal Brisbane & Women's Hospital, Queensland Haemophilia Centre
Herston, Queenland, Australia, 4029
Actively Recruiting
12
Medical University of Vienna
Vienna, State of Vienna, Austria
Completed
13
Centro de Hemoterapia e Hematologia do Rio de Janeiro HEMORIO
Rio de Janeiro, Rio de Janeiro, Brazil, 20211-030
Actively Recruiting
14
Hemocentro Unicamp
Campinas, São Paulo, Brazil, 13083-878
Actively Recruiting
15
Hospital das Clinicas - USP Endereco
São Paulo, São Paulo, Brazil, 05403-010
Actively Recruiting
16
Hamilton Health Sciences Corporation
Hamilton, Ontario, Canada, L8N 3Z5
Actively Recruiting
17
Queens University
Kingston, Ontario, Canada, K7L 3N6
Actively Recruiting
18
St. Michaels Hospital
Toronto, Ontario, Canada, M5B 1W8
Actively Recruiting
19
K J Somaiya Super Speciality Hospital & Research Centre
Sion, Mumbai, India, 400022
Actively Recruiting
20
Charlotte Maxeke Johannesburg Academic Hospital
Johannesburg, South Africa
Actively Recruiting
21
Queen Elizabeth Hospital Birmingham
Birmingham, Edgbaston, United Kingdom, B15 2TT
Actively Recruiting
22
University Hospital Southampton NHS Foundation Trust
Southampton, Hampshire, United Kingdom, SO16 6YD.
Actively Recruiting
23
Royal Free Hospital
London, London, United Kingdom, NW3 2QG
Actively Recruiting
24
Royal London Hospital, Clinical Haematology Research
Whitechapel, London, United Kingdom, E12ES
Actively Recruiting
25
Imperial College Healthcare NHS Trust- Queen Charlotte's & Chelsea Hospital
London, United Kingdom
Actively Recruiting
Research Team
C
Clinical Trials
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
5
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here