Actively Recruiting
A Study of Voice as a Way to Monitor for Side Effects in People Receiving CAR T-Cell Therapy
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-04-27
20
Participants Needed
8
Research Sites
84 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to collect voice recordings and nervous system (neurologic) assessments from people with non-Hodgkin lymphoma (NHL) or multiple myeloma (MM) who are receiving standard treatment with CAR T-cell therapy. Researchers will study whether these voice recordings and assessments are a practical (feasible) way to monitor for immune effector cell-associated neurotoxicity syndrome (ICANS). Feasibility will be measured by tracking how many participants join the study and complete the assessments.
CONDITIONS
Official Title
A Study of Voice as a Way to Monitor for Side Effects in People Receiving CAR T-Cell Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with non-Hodgkin lymphoma or multiple myeloma confirmed by pathology
- Scheduled to receive an FDA-approved CAR-T product: Axi-cel, Liso-cel, Tisa-cel, Ide-cel, Cilta-cel, or Brexu-cel
- Ability to comply with twice daily voice recordings and daily neurologic assessments
- Age 18 years or older
- ECOG Performance Status of 0, 1, or 2
- Ability to perform twice daily voice recordings using a smartphone
- Willingness to undergo daily neurologic assessments such as ICE score and tremor evaluation
- Ownership of a smartphone
- Sufficient English proficiency to complete structured voice tasks in the study app
You will not qualify if you...
- Pre-existing neurological conditions that significantly impair speech, such as severe dysarthria, expressive aphasia, or neurodegenerative disorders
- History of significant speech or voice disorders, including laryngeal paralysis, severe dysphonia, or recent vocal cord surgery or radiation
- Vocal cord pathology affecting voice analysis, such as vocal cord paralysis, chronic laryngitis, nodules, polyps, granulomas, or malignancies
- Severe hearing impairment interfering with voice assessments
- Language barriers preventing reliable completion of voice tasks or data interpretation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
Memorial Sloan Kettering at Basking Ridge (Consent Only)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (Consent only)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (Consent Only)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Suffolk-Commack (Consent Only)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (Consent only)
Harrison, New York, United States, 10604
Actively Recruiting
6
Weill Cornell Medical Center (Data Analysis Only)
New York, New York, United States, 10021
Not Yet Recruiting
7
Memorial Sloan Kettering Cancer Center (All Protocol Activites)
New York, New York, United States, 10065
Actively Recruiting
8
Memorial Sloan Kettering Nassau (Consent Only)
Rockville Centre, New York, United States, 11553
Actively Recruiting
Research Team
R
Roni Shouval, MD, PhD
CONTACT
M
Mohammad Alhomoud, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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