Actively Recruiting
Study of Volrustomig in Women With High Risk Locally Advanced Cervical Cancer (eVOLVE-Cervical)
Led by AstraZeneca · Updated on 2026-04-30
800
Participants Needed
204
Research Sites
366 weeks
Total Duration
On this page
Sponsors
A
AstraZeneca
Lead Sponsor
G
Gynecologic Oncology Group Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a phase III, randomized, double-blind, placebo-controlled, multi-center, global study to explore the efficacy and safety of volrustomig in women with high-risk LACC (FIGO 2018 stage IIIA to IVA cervical cancer) who have not progressed following platinum-based CCRT.
CONDITIONS
Official Title
Study of Volrustomig in Women With High Risk Locally Advanced Cervical Cancer (eVOLVE-Cervical)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female.
- Aged at least 15 years at the time of screening, with physical changes aligned with Tanner Stage III if under 18.
- Body weight greater than 35 kg.
- Histologically confirmed FIGO 2018 Stage IIIA to IVA cervical adenocarcinoma, squamous carcinoma, or adenosquamous carcinoma without metastatic disease.
- Initial staging performed within 56 days before first dose of concurrent chemoradiation therapy (CCRT).
- Provision of FFPE tumor sample for PD-L1 expression assessment.
- No progression following platinum-based CCRT; persistent disease must be unsuitable for curative therapies.
- WHO/ECOG performance status of 0 or 1 with life expectancy of at least 12 weeks.
- Adequate organ and bone marrow function.
- Able to provide signed informed consent.
You will not qualify if you...
- Diagnosis of small cell (neuroendocrine) or mucinous adenocarcinoma of cervical cancer.
- Evidence of metastatic disease.
- Planned fertility-sparing treatment.
- History of organ or allogenic stem cell transplant.
- Active primary immunodeficiency or documented autoimmune/inflammatory disorders.
- Uncontrolled intercurrent illness.
- History of another primary malignancy except if treated with curative intent with no active disease for at least 2 years, or adequately treated nonmelanoma skin cancer, lentigo maligna, or carcinoma in situ without disease evidence.
- Unresolved toxicities from prior CCRT except irreversible toxicity not expected to worsen.
- Prior or current vesicovaginal, colovaginal, or rectovaginal fistula.
- History of anaphylaxis to biologic therapies or vaccines.
- Immunosuppressive medication use within 14 days before study intervention except specified exceptions.
- Previous hysterectomy or planned hysterectomy as part of initial cervical cancer therapy.
- Any prior or concurrent cervical cancer treatment other than CCRT.
- Major surgery within 4 weeks before study intervention or incomplete recovery.
- Prior exposure to immune-mediated therapy.
- Live attenuated vaccine within 30 days before study intervention.
- Known allergy or hypersensitivity to study treatment or its components.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 204 locations
1
Research Site
Birmingham, Alabama, United States, 35233
Withdrawn
2
Research Site
Phoenix, Arizona, United States, 85016
Withdrawn
3
Research Site
Tucson, Arizona, United States, 85711
Withdrawn
4
Research Site
Little Rock, Arkansas, United States, 72205
Withdrawn
5
Research Site
La Jolla, California, United States, 92093
Withdrawn
6
Research Site
West Hollywood, California, United States, 90048
Withdrawn
7
Research Site
Atlanta, Georgia, United States, 30322
Withdrawn
8
Research Site
Augusta, Georgia, United States, 30912
Withdrawn
9
Research Site
Savannah, Georgia, United States, 31405
Terminated
10
Research Site
Melrose Park, Illinois, United States, 60160
Withdrawn
11
Research Site
Indianapolis, Indiana, United States, 46202
Withdrawn
12
Research Site
New Orleans, Louisiana, United States, 70112
Withdrawn
13
Research Site
New Orleans, Louisiana, United States, 70121
Withdrawn
14
Research Site
Shreveport, Louisiana, United States, 71103
Completed
15
Research Site
New York, New York, United States, 10016
Withdrawn
16
Research Site
Syracuse, New York, United States, 13210
Withdrawn
17
Research Site
Cleveland, Ohio, United States, 44195
Withdrawn
18
Research Site
Columbus, Ohio, United States, 43210
Withdrawn
19
Research Site
Eugene, Oregon, United States, 97401
Withdrawn
20
Research Site
Philadelphia, Pennsylvania, United States, 19107
Withdrawn
21
Research Site
Providence, Rhode Island, United States, 02905
Withdrawn
22
Research Site
Dallas, Texas, United States, 75390
Withdrawn
23
Research Site
Fort Worth, Texas, United States, 76104
Terminated
24
Research Site
Houston, Texas, United States, 77030
Withdrawn
25
Research Site
Tyler, Texas, United States, 75702
Withdrawn
26
Research Site
Charlottesville, Virginia, United States, 22908
Completed
27
Research Site
Fairfax, Virginia, United States, 22031
Withdrawn
28
Research Site
Richmond, Virginia, United States, 23298
Withdrawn
29
Research Site
Barretos, Brazil, 14784-400
Actively Recruiting
30
Research Site
Belo Horizonte, Brazil, 30130-100
Actively Recruiting
31
Research Site
Curitiba, Brazil, 80730-150
Actively Recruiting
32
Research Site
Fortaleza, Brazil, 60336-045
Actively Recruiting
33
Research Site
Fortaleza, Brazil, 60430-230
Not Yet Recruiting
34
Research Site
Goiânia, Brazil, 74110-060
Not Yet Recruiting
35
Research Site
Natal, Brazil, 59075-740
Actively Recruiting
36
Research Site
Porto Alegre, Brazil, 90570-060
Not Yet Recruiting
37
Research Site
Porto Alegre, Brazil, 90619-900
Actively Recruiting
38
Research Site
Porto Alegre, Brazil, 98850-170
Actively Recruiting
39
Research Site
Porto Velho, Brazil, 76834-899
Actively Recruiting
40
Research Site
Recife, Brazil, 52010-075
Actively Recruiting
41
Research Site
Rio de Janeiro, Brazil, 20220-410
Actively Recruiting
42
Research Site
Salvador, Brazil, 40050 410
Actively Recruiting
43
Research Site
São Paulo, Brazil, 01246-000
Actively Recruiting
44
Research Site
São Paulo, Brazil, 01323-000
Not Yet Recruiting
45
Research Site
São Paulo, Brazil, 1323001
Actively Recruiting
46
Research Site
Teresina, Brazil, 64049-200
Actively Recruiting
47
Research Site
Hamilton, Ontario, Canada, L8V 1C3
Actively Recruiting
48
Research Site
London, Ontario, Canada, N6A 5W9
Withdrawn
49
Research Site
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
50
Research Site
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
51
Research Site
Montreal, Quebec, Canada, H2X 0C1
Actively Recruiting
52
Research Site
Montreal, Quebec, Canada, H3G 1A4
Actively Recruiting
53
Research Site
Ste-Foy, Quebec, Canada, G1V 4G2
Withdrawn
54
Research Site
Beijing, China, 100026
Not Yet Recruiting
55
Research Site
Beijing, China, 100142
Actively Recruiting
56
Research Site
Beijing, China, 100730
Actively Recruiting
57
Research Site
Changde, China, 415000
Actively Recruiting
58
Research Site
Changsha, China, 410008
Actively Recruiting
59
Research Site
Changsha, China, 410013
Actively Recruiting
60
Research Site
Chengdu, China, 610041
Actively Recruiting
61
Research Site
Chengdu, China, 610044
Actively Recruiting
62
Research Site
Chongqing, China, 400030
Actively Recruiting
63
Research Site
Fuzhou, China, 350014
Actively Recruiting
64
Research Site
Ganzhou, China, 341000
Actively Recruiting
65
Research Site
Guangzhou, China, 510060
Actively Recruiting
66
Research Site
Guangzhou, China, 510120
Suspended
67
Research Site
Hangzhou, China, 310022
Actively Recruiting
68
Research Site
Harbin, China, 150081
Actively Recruiting
69
Research Site
Kunming, China, 650118
Actively Recruiting
70
Research Site
Lanzhou, China, 730000
Actively Recruiting
71
Research Site
Lanzhou, China, 730050
Actively Recruiting
72
Research Site
Linyi, China, 276001
Actively Recruiting
73
Research Site
Luzhou, China, 646000
Withdrawn
74
Research Site
Nanchang, China, 330006
Actively Recruiting
75
Research Site
Nanchang, China, 330029
Actively Recruiting
76
Research Site
Shandong, China
Withdrawn
77
Research Site
Shanghai, China, 200032
Actively Recruiting
78
Research Site
Shanghai, China, 200080
Actively Recruiting
79
Research Site
Shenyang, China, 110004
Actively Recruiting
80
Research Site
Shenzhen, China, 518036
Not Yet Recruiting
81
Research Site
Shenzhen, China, 518116
Actively Recruiting
82
Research Site
Tianjin, China, 300060
Actively Recruiting
83
Research Site
Wuhan, China, 430022
Actively Recruiting
84
Research Site
Wuhan, China, 430030
Actively Recruiting
85
Research Site
Xi'an, China, 710061
Actively Recruiting
86
Research Site
Yibin, China, 610500
Withdrawn
87
Research Site
Yinchuan, China, 750004
Actively Recruiting
88
Research Site
Zhengzhou, China, 450008
Actively Recruiting
89
Research Site
Zhengzhou, China, 450052
Terminated
90
Research Site
Zhuzhou, China, 412007
Actively Recruiting
91
Research Site
Aarhus N, Denmark, 8200
Actively Recruiting
92
Research Site
København Ø, Denmark, 2100
Actively Recruiting
93
Research Site
Odense, Denmark, 5000
Actively Recruiting
94
Research Site
Berlin, Germany, 13353
Actively Recruiting
95
Research Site
Bonn, Germany, 53127
Actively Recruiting
96
Research Site
Hamburg, Germany, 20246
Actively Recruiting
97
Research Site
Leipzig, Germany, 04103
Actively Recruiting
98
Research Site
Calicut, India, 673601
Terminated
99
Research Site
Jaipur, India, 302017
Actively Recruiting
100
Research Site
Lucknow, India, 226003
Withdrawn
101
Research Site
Madurai, India, 625107
Actively Recruiting
102
Research Site
Mohali, India, 160055
Withdrawn
103
Research Site
Nagpur, India, 440001
Actively Recruiting
104
Research Site
Nashik, India, 422009
Actively Recruiting
105
Research Site
Nashik, India, 422011
Actively Recruiting
106
Research Site
New Delhi, India, 11029
Actively Recruiting
107
Research Site
Vadodara, India, 391760
Actively Recruiting
108
Research Site
Bari, Italy, 70124
Withdrawn
109
Research Site
Bologna, Italy, 40138
Actively Recruiting
110
Research Site
Catania, Italy, 95126
Actively Recruiting
111
Research Site
Florence, Italy, 50141
Actively Recruiting
112
Research Site
Lecco, Italy, 23900
Completed
113
Research Site
Milan, Italy, 20133
Actively Recruiting
114
Research Site
Milan, Italy, 20141
Actively Recruiting
115
Research Site
Milan, Italy, 20159
Actively Recruiting
116
Research Site
Monza, Italy, 20900
Actively Recruiting
117
Research Site
Naples, Italy, 80131
Actively Recruiting
118
Research Site
Roma, Italy, 161
Actively Recruiting
119
Research Site
Rome, Italy, 00168
Actively Recruiting
120
Research Site
Turin, Italy, 10128
Actively Recruiting
121
Research Site
Fukuoka, Japan, 812-8582
Actively Recruiting
122
Research Site
Ginowan-shi, Japan, 901-2725
Actively Recruiting
123
Research Site
Hidaka-shi, Japan, 350-1298
Actively Recruiting
124
Research Site
Kagoshima, Japan, 890-8520
Actively Recruiting
125
Research Site
Kōtoku, Japan, 135-8550
Actively Recruiting
126
Research Site
Kurume-shi, Japan, 830-0011
Actively Recruiting
127
Research Site
Maebashi, Japan, 371-8511
Actively Recruiting
128
Research Site
Matsuyama, Japan, 791-0280
Actively Recruiting
129
Research Site
Morioka, Japan, 028-3695
Actively Recruiting
130
Research Site
Nagoya, Japan, 464-8681
Actively Recruiting
131
Research Site
Osaka, Japan, 541-8567
Withdrawn
132
Research Site
Sapporo, Japan, 003-0804
Actively Recruiting
133
Research Site
Sapporo, Japan, 060-8638
Withdrawn
134
Research Site
Shinjuku-ku, Japan, 160-8582
Actively Recruiting
135
Research Site
Suita-shi, Japan, 565-0871
Actively Recruiting
136
Research Site
Sunto-gun, Japan, 411-8777
Actively Recruiting
137
Research Site
Toon-Shi, Japan, 791-0295
Actively Recruiting
138
Research Site
Coyoacán, Mexico, 04380
Actively Recruiting
139
Research Site
Culiacán, Mexico, 80040
Withdrawn
140
Research Site
Guadalajara, Mexico, 44650
Actively Recruiting
141
Research Site
Guadalajra, Mexico, 44260
Withdrawn
142
Research Site
Mexico City, Mexico, 03240
Actively Recruiting
143
Research Site
México, Mexico, 04700
Actively Recruiting
144
Research Site
México, Mexico, 14080
Withdrawn
145
Research Site
Monterrey, Mexico, 64460
Actively Recruiting
146
Research Site
Oslo, Norway, 424
Actively Recruiting
147
Research Site
Trondheim, Norway, 7030
Actively Recruiting
148
Research Site
Concepción, Peru, 12125
Terminated
149
Research Site
Lima, Peru, 15036
Actively Recruiting
150
Research Site
Lima, Peru, 15038
Actively Recruiting
151
Research Site
Lima, Peru, 15102
Actively Recruiting
152
Research Site
Lima, Peru, LIMA 29
Actively Recruiting
153
Research Site
Lima, Peru, Lima 34
Not Yet Recruiting
154
Research Site
Lima, Peru, Lima39
Actively Recruiting
155
Research Site
Bialystok, Poland, 15-027
Actively Recruiting
156
Research Site
Gdansk, Poland, 80-214
Actively Recruiting
157
Research Site
Gliwice, Poland, 44-101
Actively Recruiting
158
Research Site
Krakow, Poland, 30-348
Withdrawn
159
Research Site
Lodz, Poland, 90-513
Withdrawn
160
Research Site
Poznan, Poland, 61-866
Actively Recruiting
161
Research Site
Warsaw, Poland, 02-781
Withdrawn
162
Research Site
Wroclaw, Poland, 53-413
Actively Recruiting
163
Research Site
San Juan, Puerto Rico, 00927
Withdrawn
164
Research Site
Daegu, South Korea, 42601
Actively Recruiting
165
Research Site
Goyang-si, South Korea, 10408
Actively Recruiting
166
Research Site
Gyeonggi-do, South Korea, 13605
Actively Recruiting
167
Research Site
Seoul, South Korea, 03080
Actively Recruiting
168
Research Site
Seoul, South Korea, 03722
Actively Recruiting
169
Research Site
Seoul, South Korea, 06351
Actively Recruiting
170
Research Site
Seoul, South Korea, 5505
Actively Recruiting
171
Research Site
A Coruña, Spain, 15009
Actively Recruiting
172
Research Site
Barcelona, Spain, 08036
Actively Recruiting
173
Research Site
Barcelona, Spain, 8035
Actively Recruiting
174
Research Site
Córdoba, Spain, 14004
Actively Recruiting
175
Research Site
Girona, Spain, 17007
Actively Recruiting
176
Research Site
Hospitalet deLlobregat, Spain, 08907
Actively Recruiting
177
Research Site
Madrid, Spain, 28034
Actively Recruiting
178
Research Site
Madrid, Spain, 28040
Actively Recruiting
179
Research Site
Madrid, Spain, 28041
Actively Recruiting
180
Research Site
Madrid, Spain, 28046
Withdrawn
181
Research Site
Palma de Mallorca, Spain, 07010
Withdrawn
182
Research Site
Valencia, Spain, 46009
Actively Recruiting
183
Research Site
Valencia, Spain, 46010
Withdrawn
184
Research Site
Changhua, Taiwan, 50006
Actively Recruiting
185
Research Site
Kaohsiung City, Taiwan, 81362
Actively Recruiting
186
Research Site
Kaohsiung City, Taiwan, 833
Actively Recruiting
187
Research Site
New Taipei City, Taiwan, 220
Actively Recruiting
188
Research Site
Taichung, Taiwan, 40447
Actively Recruiting
189
Research Site
Taichung, Taiwan, 40705
Actively Recruiting
190
Research Site
Tainan, Taiwan, 704
Actively Recruiting
191
Research Site
Taipei, Taiwan, 10449
Actively Recruiting
192
Research Site
Taipei, Taiwan, 11217
Actively Recruiting
193
Research Site
Taoyuan, Taiwan, 333
Actively Recruiting
194
Research Site
Bangkok, Thailand, 10330
Actively Recruiting
195
Research Site
Bangkok, Thailand, 10400
Actively Recruiting
196
Research Site
Bangkok, Thailand, 10700
Actively Recruiting
197
Research Site
Muang, Thailand, 50200
Actively Recruiting
198
Research Site
Udon Thani, Thailand, 41330
Actively Recruiting
199
Research Site
Adana, Turkey (Türkiye), 01250
Actively Recruiting
200
Research Site
Ankara, Turkey (Türkiye), 06100
Actively Recruiting
201
Research Site
Ankara, Turkey (Türkiye), 06490
Actively Recruiting
202
Research Site
Cordaleo, Turkey (Türkiye), 35575
Actively Recruiting
203
Research Site
Istanbul, Turkey (Türkiye), 32098
Withdrawn
204
Research Site
Istanbul, Turkey (Türkiye), 34214
Withdrawn
Research Team
A
AstraZeneca Clinical Study Information Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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