Actively Recruiting
A Study of VRT106 for Injection in Patients With Recurrent/Progressive Glioblastoma
Led by Guangzhou Virotech Pharmaceutical Co., Ltd. · Updated on 2026-01-02
42
Participants Needed
11
Research Sites
199 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is an open-label, single-arm Phase I/II clinical trial with the primary objective of evaluating the safety, tolerability, and efficacy of VRT106 in patients with recurrent/progressive glioblastoma.
CONDITIONS
Official Title
A Study of VRT106 for Injection in Patients With Recurrent/Progressive Glioblastoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects willingly participate, understand the study, and can complete all procedures
- Male or female aged 18 to 70 years
- Diagnosed with recurrent or progressive glioblastoma
- Karnofsky Performance Status score of 60 or higher within 28 days before first study drug dose
- Expected survival time of at least 3 months
- Have sufficient organ function
- Female patients of childbearing potential must have a negative pregnancy test within 7 days before first study drug dose
- Subjects of childbearing potential agree to use effective birth control from consent signing to at least 90 days after last dose
You will not qualify if you...
- Patients with extracranial metastases
- Prior treatment with oncolytic viruses or gene therapy
- Received other unlisted investigational drugs or devices within 4 weeks before first VRT106 dose
- Known allergy to any components of VRT106
- Unable to have a cranial MRI scan
- Women who are breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 11 locations
1
The First Affiliated Hospital of USTC
Hefei, Anhui, China
Not Yet Recruiting
2
Sanbo Brain Hospital Capital Medical University
Beijing, Beijing Municipality, China
Not Yet Recruiting
3
The Cancer Hospital Affiliated to Chongqing University
Chongqing, Chongqing Municipality, China
Not Yet Recruiting
4
Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China
Not Yet Recruiting
5
Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China
Actively Recruiting
6
Shenzhen Second People's Hospital
Shenzhen, Guangdong, China
Actively Recruiting
7
The Fifth Affiliated Hospital of Sun Yat-sen University
Zhuhai, Guangdong, China
Actively Recruiting
8
Guangxi Medical University Cancer Hospital
Nanning, Guangxi, China
Actively Recruiting
9
Qilu Hospital of Shandong University
Jinan, Shandong, China
Not Yet Recruiting
10
Tangdu Hospital of Air Force Medical University of the PLA
Xi’an, Shanxi, China
Not Yet Recruiting
11
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Actively Recruiting
Research Team
C
Chengcheng Guo
CONTACT
K
Ke Sai
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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