Actively Recruiting
Study of WAL0921 in Patients With Glomerular Kidney Diseases
Led by Walden Biosciences · Updated on 2026-04-02
96
Participants Needed
50
Research Sites
152 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is an adaptive prospective, multi-center, randomized, double-blind, placebo-controlled study to evaluate the safety, efficacy, pharmacokinetics, and pharmacodynamics of WAL0921 in subjects with glomerular kidney disease and proteinuria, including diabetic nephropathy and rare glomerular kidney diseases (primary focal segmental glomerulosclerosis \[FSGS\], treatment-resistant minimal change disease \[TR MCD\], primary immunoglobulin A nephropathy \[IgAN\], and primary membranous nephropathy \[PMN\]). Subjects in this study will be randomized to receive the investigational drug WAL0921 or placebo as an intravenous infusion once every 2 weeks for 7 total infusions. All subjects will be followed for 24 weeks after their last infusion.
CONDITIONS
Official Title
Study of WAL0921 in Patients With Glomerular Kidney Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults, age 18-75 years
- Diagnosis of one of the following glomerular kidney diseases: diabetic nephropathy; primary focal segmental glomerulosclerosis; treatment resistant-minimal change disease; primary IgA nephropathy; primary membranous nephropathy
- eGFR greater than or equal to 30 mL/min/1.73 m2
You will not qualify if you...
- Currently pregnant or planning to become pregnant
- History of organ transplantation
- History of alcohol or substance use disorder
- Acute dialysis or acute kidney injury within 6 months of Screening
- Any prior or current medical condition that would prevent safe participation or completion of study requirements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 50 locations
1
Academic Medical Research Institute
Los Angeles, California, United States, 90022
Actively Recruiting
2
Colorado Kidney and Vascular Care
Denver, Colorado, United States, 80012
Actively Recruiting
3
D & H Tamarac Research Center
Tamarac, Florida, United States, 33321
Actively Recruiting
4
Fides Clinical Research
Atlanta, Georgia, United States, 30342
Actively Recruiting
5
Nephrology Associates of Northern Illinois and Indiana (NANI)
Hinsdale, Illinois, United States, 60521
Actively Recruiting
6
Dunes Clinical Research
Dakota Dunes, South Dakota, United States, 57049
Actively Recruiting
7
Prolato Clinical Research Center
Houston, Texas, United States, 77054
Actively Recruiting
8
Clinical Trial Network
Houston, Texas, United States, 77074
Actively Recruiting
9
Clinical Advancement Center
San Antonio, Texas, United States, 78212
Actively Recruiting
10
Westmead Hospital
Westmead, New South Wales, Australia, 2145
Actively Recruiting
11
Western Health Sunshine Hospital
St Albans, Victoria, Australia, 3021
Actively Recruiting
12
AIIMS Hospital
Raipur, Chhattisgarh, India, 492099
Actively Recruiting
13
Muljibhai Patel Urological Hospital
Nadiād, Gujarat, India, 387003
Actively Recruiting
14
Dhiraj Hospital
Vadodara, Gujarat, India, 391760
Actively Recruiting
15
MS Ramaiah Medical College and Hospitals
Bangalore, Karnataka, India, 560054
Actively Recruiting
16
Mazumdar Shah Medical Center
Bangalore, Karnataka, India, 560099
Actively Recruiting
17
Manipal Hospital
Pune, Maharashtra, India, 411045
Actively Recruiting
18
MGM Medical Care and Hospital
Sambhajinagar, Maharashtra, India, 431003
Actively Recruiting
19
Sir Ganga Ram Hospital
New Delhi, National Capital Territory of Delhi, India, 110060
Actively Recruiting
20
Max Super Speciality Hospital
Patparganj, National Capital Territory of Delhi, India, 110092
Actively Recruiting
21
SUM Hospital
Bhubaneswar, Odisha, India, 751029
Actively Recruiting
22
SMS Medical College and Hospital
Jaipur, Rajasthan, India, 302004
Actively Recruiting
23
Osmania General Hospital
Hyderabad, Telangana, India, 500012
Actively Recruiting
24
Nizam's Institute of Medical Sciences
Hyderabad, Telangana, India, 500082
Actively Recruiting
25
Sanjay Gandhi Post Graduate Institute of Medical Sciences
Lucknow, Uttar Pradesh, India, 226014
Actively Recruiting
26
Nutema Hospital
Meerut, Uttar Pradesh, India, 250002
Actively Recruiting
27
Shri Guru Ram Rai Institute of Medical and Health Sciences
Dehradun, Uttarakhand, India, 248001
Actively Recruiting
28
NRS Medical College and Hospital Kolkata
Kolkata, West Bengal, India, 700014
Actively Recruiting
29
Hospital Canselor Tuanku Muhriz UKM
Cheras, Kuala Lumpur, Malaysia, 56000
Actively Recruiting
30
Hospital Kuala Lumpur
Kuala Lumpur, Kuala Lumpur, Malaysia, 50586
Actively Recruiting
31
University Malaya Medical Centre
Kuala Lumpur, Kuala Lumpur, Malaysia, 50603
Actively Recruiting
32
Hospital Tengku Ampuan Afzan
Kuantan, Pahang, Malaysia, 25100
Actively Recruiting
33
Hospital Sultan Idris Shah Serdang
Kajang, Selangor, Malaysia, 43000
Actively Recruiting
34
Sunway Medical Centre
Petaling Jaya, Selangor, Malaysia, 47500
Actively Recruiting
35
Hallym University Sacred Heart Hospital
Anyang, South Korea, 14068
Actively Recruiting
36
Pusan National University Hospital
Busan, South Korea, 49241
Actively Recruiting
37
Seoul National University Bundang Hospital
Seongnam-si, South Korea, 13620
Actively Recruiting
38
Severance Hospital - Yonsei Cancer Center
Seoul, South Korea, 03722
Actively Recruiting
39
Samsung Medical Center
Soeul, South Korea, 06351
Actively Recruiting
40
Ajou University Hospital
Suwon, South Korea, 16499
Actively Recruiting
41
National Hospital of Sri Lanka
Colombo, Sri Lanka, 00700
Not Yet Recruiting
42
Jaffna Teaching Hospital
Jaffna, Sri Lanka, 40000
Not Yet Recruiting
43
Kandy National Hospital
Kandy, Sri Lanka, 20000
Not Yet Recruiting
44
Kurunegala Teaching Hospital
Kurunegala, Sri Lanka, 60000
Not Yet Recruiting
45
Kothalawala Defence University Hospital
Werahera, Sri Lanka, 10290
Not Yet Recruiting
46
Royal Derby Hospital
Derby, United Kingdom, DE22 3NE
Not Yet Recruiting
47
College of Life Sciences, University of Leicester
Leicester, United Kingdom, LE1 7RH
Not Yet Recruiting
48
Barts Health NHS Trust
London, United Kingdom, E1 2ES
Not Yet Recruiting
49
Manchester University NHS Foundation Trust
Manchester, United Kingdom, M13 9WL
Not Yet Recruiting
50
Salford Royal NHS Foundation Trust
Salford, United Kingdom, M6 8HD
Not Yet Recruiting
Research Team
M
Michelle Skupien
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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