Actively Recruiting
A Study of XW003 in Obese Participants With Obstructive Sleep Apnea Receiving Positive Airway Pressure Therapy
Led by Hangzhou Sciwind Biosciences Co., Ltd. · Updated on 2026-04-13
140
Participants Needed
1
Research Sites
120 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of the study is to assess the efficacy and safety of XW003 injections in obese participants with OSA receiving PAP
CONDITIONS
Official Title
A Study of XW003 in Obese Participants With Obstructive Sleep Apnea Receiving Positive Airway Pressure Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Body mass index (BMI) greater than or equal to 28.0 kg/m2
- Diagnosis of obstructive sleep apnea with an Apnea-Hypopnea Index (AHI) of 15 or higher at screening
- On positive airway pressure (PAP) therapy for at least 3 consecutive months before screening and plan to continue during the study
- History of at least one unsuccessful attempt to lose body weight through diet
You will not qualify if you...
- History of endocrine disorders that significantly affect body weight
- Diagnosis of diabetes (except gestational diabetes), ketoacidosis, or hypertonic state/coma
- Hemoglobin A1c (HbA1c) of 6.5% or higher at screening
- Fasting blood glucose of 7.0 mmol/L or higher, or 2-hour blood glucose of 11.1 mmol/L or higher after oral glucose tolerance test at screening
- Diagnosis of Cheyne Stokes Respiration or central/mixed sleep apnea with 50% or more mixed or central apneas/hypopneas
- Respiratory or neuromuscular diseases that could affect trial results
- Diagnosis of Obesity Hypoventilation Syndrome or daytime high carbon dioxide levels
- Body weight change greater than 5% within 3 months prior to screening
- Prior or planned surgical treatment for obesity (except liposuction or abdominoplasty performed more than 1 year before screening)
- Use of medications for weight loss or blood glucose lowering, or medications causing significant weight gain, within 3 months prior to screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Rui Jin Hospital
Shanghai, Shanghai Municipality, China, 200025
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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