Actively Recruiting
A Study of ZW251 in Participants With Advanced Solid Tumors
Led by Zymeworks BC Inc. · Updated on 2026-05-07
100
Participants Needed
25
Research Sites
131 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to find out if ZW251, an antibody-drug conjugate targeting glypican-3 (GPC3), is safe and can treat participants with advanced cancers, including hepatocellular carcinoma (HCC), squamous cell non-small cell lung cancer (NSCLC), or germ cell tumors (GCT).
CONDITIONS
Official Title
A Study of ZW251 in Participants With Advanced Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis confirmed by pathology or cytology of hepatocellular carcinoma with locally advanced or metastatic disease
- Diagnosis confirmed by pathology or cytology of squamous cell non-small cell lung cancer with locally advanced or metastatic disease
- Diagnosis confirmed by pathology or cytology of germ cell tumor with yolk sac or choriocarcinoma component with locally advanced or metastatic disease
- Measurable disease according to RECIST v1.1
- ECOG Performance Status score of 0 or 1
- Liver function classified as Child-Pugh Class A (for hepatocellular carcinoma patients only)
- Adequate organ function
You will not qualify if you...
- Any other active malignancy progressing or treated within the last year
- History of hepatic encephalopathy in the past 6 months or need for medication to control it
- Main portal vein tumor invasion in hepatocellular carcinoma without sponsor approval
- Known gastrointestinal bleeding within the past 3 months
- Acute or chronic uncontrolled kidney disease, pancreatitis, or non-malignant liver disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 25 locations
1
UCSF Comprehensive Cancer Center
San Francisco, California, United States, 94158
Actively Recruiting
2
University of California Los Angeles - Cancer Care - Santa Monica (UCLA)
Santa Monica, California, United States, 90404
Actively Recruiting
3
Norton Cancer Institute
Louisville, Kentucky, United States, 40202
Actively Recruiting
4
START Midwest
Grand Rapids, Michigan, United States, 49546
Actively Recruiting
5
Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065-6800
Actively Recruiting
7
MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
8
START San Antonio
San Antonio, Texas, United States, 78229
Actively Recruiting
9
START - Dublin Mater Misericordiae University Hospital (MMUH)
Dublin, Ireland, D07 R2WY
Actively Recruiting
10
National Cancer Center East
Kashiwa, Japan, 2778577
Actively Recruiting
11
Kyoto University Hospital
Kyoto, Japan, 606-8507
Actively Recruiting
12
Kansai Medical University Hospital
Osaka, Japan, 573-1191
Actively Recruiting
13
National Cancer Center Hospital
Tokyo, Japan, 104-0045
Actively Recruiting
14
START Lisboa a - Unidade de Ensaios ClÃnicos - Hospital de Santa Maria
Lisbon, Portugal, 1649-035
Actively Recruiting
15
Unidade Local de Saúde Gaia e Espinho
Vila Nova de Gaia, Portugal, 4434-502
Actively Recruiting
16
Hospital Universitario Vall d'Hebron
Barcelona, Spain, 08035
Actively Recruiting
17
START Barcelona
Barcelona, Spain, 29010
Actively Recruiting
18
START - Rioja Hospital Universitario San Pedro
Logroño, Spain, 26006
Actively Recruiting
19
START Madrid Hospital Universitario Fundacion Jimenez Diaz
Madrid, Spain, 28040
Actively Recruiting
20
START Madrid Hospital Universitario HM Sanchinarro - CIOCC
Madrid, Spain, 28050
Actively Recruiting
21
NEXT Oncology Madrid
Madrid, Spain, 28223
Actively Recruiting
22
Hospital Universitario Virgen de la Victoria
Málaga, Spain, 29010
Actively Recruiting
23
Clinica Universidad de Navarra
Pamplona, Spain, 31008
Actively Recruiting
24
National Taiwan University Hospital
Taipei, Taiwan, 100225
Actively Recruiting
25
Taipei Veterans General Hospital
Taipei, Taiwan, 112201
Actively Recruiting
Research Team
Z
Zymeworks Clinical Trial Resource
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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