Actively Recruiting
Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI
Led by Mayo Clinic · Updated on 2025-09-18
15
Participants Needed
1
Research Sites
307 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to investigate how gut hormones and brain areas respond differently to gastric distention, tasteless calories, or palatable food and how this alters appetite.
CONDITIONS
Official Title
Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- BMI 18-25 kg/m^2.
- Weight stable for 3 months prior to study entry.
- For females: study days will be scheduled during the follicular phase of their menstrual cycle (the first 13 days of the cycle).
- Able to provide written informed consent prior to any study procedures and willing and able to follow study procedures.
- Ability to perform light to moderate physical activity.
You will not qualify if you...
- Any contraindication for MRI scanning.
- Any history of childhood (> 95th percentile) or adult obesity (BMI >30 kg/m^2).
- Claustrophobia.
- High intensity training or physical activity.
- Any contraindication for intragastric balloon insertion.
- Any allergies to the study meals.
- Any history of eating disorder.
- Any substance abuse disorder (including alcohol and tobacco).
- Any history of psychiatric disorders.
- Any cardiovascular, endocrine, pulmonary, neurological, or gastrointestinal comorbidities.
- Pregnancy or nursing.
- Any history of bariatric surgery or endoscopic bariatric procedure.
- Use of any medication or supplement that alters appetite.
- Patient has a known history of any condition or factor judged by the investigator to prevent participation in the study or which might hinder study adherence.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Mayo Clinic Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
M
Megan Schaefer
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
1
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