Subarachnoid-subarachnoid bypass: a new surgical technique for posttraumatic syringomyelia.
Tetsuo Hayashi, Takayoshi Ueta, Masahiro Kubo...
https://pubmed.ncbi.nlm.nih.gov/23432327Actively Recruiting
Phase Not Applicable
Age: 18Years - 80Years
All Genders
ID06375759
Subarachnoid-Subarachnoid (S-S) Bypass Versus Adhesion Lysis in Spinal Arachnoiditis and Syringomyelia
Led by Xuanwu Hospital, Beijing · Updated on 2024-04-19
200
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether Subarachnoid-Subarachnoid (S-S) Bypass leads to better outcomes with fewer complications and improved quality of life compared to intradural adhesion lysis in people with Spinal Arachnoiditis and Syringomyelia. This study compares two surgical approaches to treat these conditions, focusing on patient recovery and symptom improvement over time. Participants will be randomly assigned to either receive the S-S Bypass or intradural adhesion lysis. The S-S Bypass involves placing silicone tubes between the normal subarachnoid spaces after careful dissection, while adhesion lysis involves microsurgical removal of scar tissue followed by dural repair. After surgery, participants will have follow-up visits at 3-6 months, 12 months, and 24 months. During these visits, doctors will conduct physical exams, assess symptoms, and collect questionnaire responses. Spine MRIs will be done at each follow-up to monitor changes. Researchers will track complications at 12 months and evaluate improvements in syrinx size, neurological function, and spinal condition scores over the 24-month period. This monitoring helps understand the safety and effectiveness of each surgical procedure.
CONDITIONS
Brief Title
Subarachnoid-Subarachnoid (S-S) Bypass Versus Adhesion Lysis in Spinal Arachnoiditis and Syringomyelia
Who Can Participate
Age: 18Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- History of traumatic spinal cord injury or other infection
- Evidence of progressive neurological deficit and/or pain syndrome
- MRI showing syringomyelia due to spinal trauma or infection
- Willingness to be followed for more than 1 year
You will not qualify if you...
- Presence of Chiari-malformation
- Presence of myelomalacia
- Presence of subarachnoid cyst
- Syringomyelia caused by other spinal diseases such as degenerative spinal disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Surgery
Duration - Single surgical procedure
Participants undergo either Subarachnoid-Subarachnoid (S-S) Bypass or Intradural Adhesion Lysis as treatment for spinal arachnoiditis and syringomyelia.
1 visit (in-person)
Post-operative Follow-up
Duration - Up to 24 months
After surgery, participants return for follow-up visits where physical exams, symptom assessments, and questionnaires are completed. Spine MRIs are performed to monitor progress.
Visits at 3 to 6 months, 12 months, and 24 months (in-person)
Trial Site Locations
Total: 1 location
1
Fengzeng Jian
Beijing, Beijing Municipality, China, 100053
Actively Recruiting
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Research Team
F
fengzeng jian
Y
yuan chenghua
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Cerebrospinal Fluid Hydrodynamics in Chiari I Malformation and Syringomyelia: Modeling Pathophysiology.
John D Heiss
https://pubmed.ncbi.nlm.nih.gov/36424067Aquaporin-4 expression and blood-spinal cord barrier permeability in canalicular syringomyelia.
Sarah J Hemley, Lynne E Bilston, Shaokoon Cheng...
https://pubmed.ncbi.nlm.nih.gov/23082850A novel scoring system for assessing adult syringomyelia associated with CM I treatment outcomes.
Jian Guan, Chenghua Yuan, Qingyu Yao...
https://pubmed.ncbi.nlm.nih.gov/37046133Intradural Pathology Causing Cerebrospinal Fluid Obstruction in Syringomyelia and Effectiveness of Foramen Magnum and Foramen of Magendie Dredging Treatment.
Jian Guan, Chenghua Yuan, Can Zhang...
https://pubmed.ncbi.nlm.nih.gov/32805463Long-Term Impairment of the Blood-Spinal Cord Barrier in Patients With Post-Traumatic Syringomyelia and its Effect on Prognosis.
Chenghua Yuan, Pingchuan Xia, Wanru Duan...
https://pubmed.ncbi.nlm.nih.gov/38014747