Actively Recruiting
Subcision With Injection of Poly Deoxyribonucleotide Versus Subcision With Injection of Non-cross Linked Hyaluronic Acid in Rolling Acne Scars Treatment : A Split Face Randomized Controlled Clinical Trial
Led by Cairo University · Updated on 2026-04-23
20
Participants Needed
1
Research Sites
39 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study is to evaluate and compare the efficacy and safety of two different injectable agents combined with subcision for treating rolling acne scars. In this split-face clinical trial, each participant will receive subcision on both sides of the face. One side will then be treated with an injection of Polydeoxyribonucleotide (PDRN), while the other side will receive an injection of non-cross linked Hyaluronic acid (HA). The clinical outcomes and improvement in scar appearance will be assessed and compared between both treatments
CONDITIONS
Official Title
Subcision With Injection of Poly Deoxyribonucleotide Versus Subcision With Injection of Non-cross Linked Hyaluronic Acid in Rolling Acne Scars Treatment : A Split Face Randomized Controlled Clinical Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Moderate to severe mainly rolling acne scars according to Goodman & Baron Grade 3-4
- Scars must be present on both sides of the face to allow split-face comparison
- Stable acne with no active nodulocystic lesions, pustules, or outbreaks for at least 6 months
- No scar treatments (such as fillers, laser, or microneedling) within the past 12 months
- All skin types eligible
- Both genders, aged 18 years or older
You will not qualify if you...
- Use of systemic retinoid treatment within the last 6 months
- Presence of active inflammatory acne
- Sensitivity to lidocaine
- Pregnancy or breastfeeding
- Severe systemic illness or cancer
- Use of anticoagulant or antiplatelet medications unless cleared by a doctor
- Use of oral isotretinoin within the past 6 months
- Infections such as herpes labialis, bacterial infections, or viruses like HBV, HCV, or HIV
- Tendency to form keloid scars
- Allergy to fish or salmon
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cairo University, Dermatology Department
Cairo, Egypt
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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