Actively Recruiting
Subgrouping SLE - a New Approach to Understand the Pathogenesis and Improve Treatment
Led by Region Stockholm · Updated on 2025-08-03
900
Participants Needed
1
Research Sites
932 weeks
Total Duration
On this page
Sponsors
R
Region Stockholm
Lead Sponsor
K
Karolinska Institutet
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to investigate different phenotypes among patients with SLE and to compare with matched general population controls. The main questions we aim to answer are: A To investigate if subgroups of patients with systemic lupus erythematosus (SLE) defined by autoantibodies, genetic predisposition or biomarkers, rather than the present diagnostic entities account for the high risk of premature vascular disease. B To perform in depth studies of selected patient groups to shed light on the autoimmune mechanisms behind antiphospholipid (aPL) antibodies and nephritis and their association to vascular disease in SLE and APS Participants will be investigated in person by a nurse and a rheumatologist. Data on previous and present disease characteristics, anthropometric measurements and health related quality of life (according to selfreported questionnaires) will be entered into a data base. Blood samples (plasma serum and DNA), urine and saliva is stored in a corresponding biobank. Researchers will compare identified subgroups of SLE patients to each other and to matched population controls.
CONDITIONS
Official Title
Subgrouping SLE - a New Approach to Understand the Pathogenesis and Improve Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of systemic lupus erythematosus (SLE) according to ACR82 or SLICC 2012 criteria
- Consent to participate in the study
You will not qualify if you...
- Unable to read or understand patient information due to language difficulties or psychological/psychiatric conditions
- Not consenting to participate
AI-Screening
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Trial Site Locations
Total: 1 location
1
Karolinska University Hospital
Stockholm, Sweden, 17176
Actively Recruiting
Research Team
E
Elisabet Svenungsson, MD, PhD
CONTACT
I
Iva Gunnarsson, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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