Actively Recruiting
Submaximal Cardiopulmonary Exercise Testing for Detection of Myocardial Injury After Noncardiac Surgery
Led by Yale University · Updated on 2026-02-06
61
Participants Needed
1
Research Sites
96 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn whether physicians can associate evidence of myocardial injury after surgery with findings obtained from submaximal cardiopulmonary exercise testing. The main questions are: Is detection of postoperative myocardial injury with submaximal cardiopulmonary exercise testing superior to using usual care? And which submaximal cardiopulmonary exercise testing measure is better? Participants will undergo evaluation with a short submaximal cardiopulmonary exercise test, then undergo surgery. Myocardial injury will be measured on postoperative days 0, 1, 2, and 3 (during and up to 3 days after surgery). These results will analyzed by comparing it to findings from the submaximal cardiopulmonary exercise test. If there is a relationship, this will help anesthesiologists and surgeons assign certain treatments that may reduce the risk of developing myocardial injury after surgery.
CONDITIONS
Official Title
Submaximal Cardiopulmonary Exercise Testing for Detection of Myocardial Injury After Noncardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent form.
- Willing to comply with all study procedures and be available for the study duration.
- Biological male or female aged 45 years or older.
- In good general health or able to climb one flight of stairs.
- Revised Cardiac Risk Index of 3 or less.
- Willing to have blood samples taken on operative day 0, 1, 2, and 3.
- Scheduled for moderate to high-risk elective non-cardiac surgery with a 24-72 hour hospital stay expected within 60 days of enrollment.
You will not qualify if you...
- Unable to perform study procedures or climb one flight of stairs reliably.
- Pregnancy or breastfeeding.
- Unable to provide independent informed consent.
- Revised Cardiac Risk Index greater than 3.
- Myocardial infarction within the last 6 weeks.
- Anginal symptoms within the past 6 months.
- Hospital admission for congestive heart failure within 6 months.
- Hospital admission for syncope within 6 months.
- Symptomatic abnormal heart rhythms (tachycardia or bradycardia).
- Severe uncorrected heart valve disease.
- Pulmonary embolism or deep vein thrombosis within past 6 months.
- Uncontrolled pulmonary edema or symptomatic cardiac arrhythmias.
- Active infections such as endocarditis, myocarditis, or pericarditis.
- Active wheezing or recent COPD exacerbation requiring admission.
- Physical limitations affecting test performance (severe hip/knee osteoarthritis, limb immobilization, balance problems).
- Diagnosis of symptomatic vertigo.
- Allergies to components of the test equipment mouthpiece.
- Current enrollment in another interventional clinical trial.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Yale University; Yale New Haven Hospital
New Haven, Connecticut, United States, 06510
Actively Recruiting
Research Team
Z
Zyad J Carr, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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