Actively Recruiting
Submental Flap for the Reconstruction of Hypopharyngectomy
Led by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Updated on 2023-12-08
40
Participants Needed
1
Research Sites
365 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to assess the safety and efficacy of submental artery island flap (SMAIF) in the reconstruction of laryngeal and hypopharyngal defects after the surgical resection of hypopharyngeal cancer. The main questions it aims to answer are: * The survival of SMAIF and the recovery of laryngeal function. * The oncologic outcomes of SMAIF comparing with other reconstructions or radiotherapy. Participants will underwent partial laryngectomy and hypopharyngectomy and reconstruction of SMAIF. Postoperative adjuvant radiotherapy will be recommented when adverse pathologic features were noted.
CONDITIONS
Official Title
Submental Flap for the Reconstruction of Hypopharyngectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- T2-T3 hypopharyngeal squamous cell carcinoma located in the piriform sinus or posterior hypopharyngeal wall cancer
- The contralateral hemilarynx is mobile
- Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1
- No history of radiotherapy
You will not qualify if you...
- Invasion into the cricoid cartilage making larynx preservation impossible
- Pulmonary insufficiency with FEV1/FVC less than 50%
- Unresectable neck diseases including carotid artery involvement or tumor penetration to prevertebral fascia or mediastinum
- Heart insufficiency that prevents tolerating general anesthesia
- Presence of distant metastasis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China, 510120
Actively Recruiting
Research Team
R
Renhui Chen, MD
CONTACT
L
Liushan Ou, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here