Actively Recruiting
Substance Use in Pregnant People - Optimizing Retention in Treatment
Led by Washington University School of Medicine · Updated on 2026-02-04
40
Participants Needed
2
Research Sites
25 weeks
Total Duration
On this page
Sponsors
W
Washington University School of Medicine
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Substance use during pregnancy is a leading cause of maternal morbidity and mortality in the United States, with 55-80% of postpartum patients disengaging from substance use disorder (SUD) treatment within one year of delivery. Structural and social determinants of health, including housing instability, transportation barriers, and limited childcare access, further exacerbate disparities in treatment retention. This pilot study, conducted in two specialized prenatal care clinics, evaluates the feasibility and acceptability of two integrated strategies to promote sustained engagement in recovery-oriented services during the perinatal and postpartum periods. Aim 1 implements a standardized social needs screening and referral protocol to connect patients with community-based supports. Aim 2 pilots a contingency management intervention to incentivize recovery-supportive behaviors. Findings will inform the design of a larger multi-site randomized controlled trial to evaluate the impact of these interventions on treatment retention, overdose prevention, and maternal-infant health outcomes.
CONDITIONS
Official Title
Substance Use in Pregnant People - Optimizing Retention in Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed viable intrauterine pregnancy at any gestational age, or within three years postpartum
- Diagnosis of substance use disorder (SUD) as defined in DSM-5 or by clinician documentation
You will not qualify if you...
- Decline follow-up care at study site
- Require immediate hospitalization for unstable medical or psychiatric conditions making participation unsafe
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University of Maryland
Baltimore, Maryland, United States, 21201
Not Yet Recruiting
2
Washington University
St Louis, Missouri, United States, 63108
Actively Recruiting
Research Team
M
Melissa M Mills, BS
CONTACT
J
Jeannie C Kelly, MD, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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