Actively Recruiting
Subtyping Primary Aldosteronism With Para-chloro-2-[18F]Fluoroethyl-etomidate
Led by University Medical Center Groningen · Updated on 2025-01-27
12
Participants Needed
1
Research Sites
129 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to investigate the uptake characteristics of \[18F\]CETO in adrenal tissue in patients with two different subtypes of primary aldosteronism. The main questions it aims to answer are: * What are the uptake characteristics of \[18F\]CETO in adrenal tissue in patients with primary aldosteronism? * What is the concordance between the adrenal vein sampling and the \[18F\]CETO PET/CT scan results? * What is the effect of adrenal perfusion on \[18F\]CETO uptake in the adrenal glands? Researchers will compare the results of the adrenal vein sampling to a \[18F\]CETO PET/CT scan to see if the PET/CT can accurately identify the subtypes of primary aldosteronism. Participants will: * Take dexamethasone three days prior to the scan * Undergo a \[18F\]CETO PET/CT * Report burden of pre-treatment and PET/CT scan
CONDITIONS
Official Title
Subtyping Primary Aldosteronism With Para-chloro-2-[18F]Fluoroethyl-etomidate
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged above 18 years
- Biochemically confirmed diagnosis of primary aldosteronism
- Completion of standard diagnostic work-up for primary aldosteronism
- Ability to follow and understand study instructions
- Ability to provide written informed consent
You will not qualify if you...
- Diabetes mellitus with HbA1c above 42 mmol/mol or elevated fasting/non-fasting plasma glucose
- Serious health problems preventing surgery
- Severe claustrophobia
- Pregnancy, breastfeeding, or inability/unwillingness to use effective contraception (female only)
- Active infections such as viral, fungal, or parasitic infections
- Difficult venous access
- Unwillingness or inability to take dexamethasone before the PET/CT scan
- Inability to temporarily stop medications that affect aldosterone secretion
- Use of ketoconazole, metyrapone, or cytostatic drugs in the past 6 months
- Long-term use of prednisolone or dexamethasone
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Medical Center Groningen
Groningen, Provincie Groningen, Netherlands, 9713 GZ
Actively Recruiting
Research Team
D
dr. M.N. Kerstens
CONTACT
M
Merit Schaafsma, MD-PhD candidate
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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