Actively Recruiting
Evaluation of the Success Rate of Endodontic Treatment Using Different Obturation Techniques and Root Canal Sealer Cements: A Randomized Controlled Trial
Led by University of Siena · Updated on 2025-06-13
270
Participants Needed
1
Research Sites
178 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to compare the success of root canal treatments using two different sealers, AH Plus and NeoSealer Flo, along with two obturation techniques: continuous wave and single cone. The study involves 270 patients with conditions such as pulpal necrosis, irreversible pulpitis, and various periapical pathologies. It focuses on evaluating healing and quality of treatment over at least six months to understand the effectiveness of bioceramic sealer regardless of technique used. Participants will receive root canal filling using one of four combinations: AH Plus with continuous wave condensation, AH Plus with single cone, NeoSealer Flo with continuous wave, or NeoSealer Flo with single cone. AH Plus is a resin-based sealer, while NeoSealer Flo is a bioceramic, calcium silicate-based sealer. The continuous wave method uses heated gutta-percha to fill the canal densely, whereas the single cone technique uses a single cone and a high-flow sealer for simpler application. During the study, clinical and radiographic assessments will be made, including evaluating obturation quality, lesion healing, and restorations. The main measure is radiographic success based on Periapical Index criteria at a minimum of six months after treatment. Secondary measures include clinical symptom absence and CBCT imaging outcomes. Patient follow-up and adherence to evaluation schedules are important to monitor treatment success, with participation lasting at least six months post-treatment.
CONDITIONS
Brief Title
Success of Endodontic Treatment With Different Obturation Techniques and Sealer Cements
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years and older
- Teeth diagnosed with pulpal necrosis or irreversible pulpitis
- Provided informed consent for data usage
You will not qualify if you...
- Patients with systemic conditions that may impair healing (e.g., uncontrolled diabetes, immunosuppression)
- Teeth with root fractures, resorption, or open apices
- Incomplete clinical or radiographic records
- Poor-quality or non-standardized radiographs for evaluation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single session on treatment day
Participants receive root canal treatment using one of four obturation techniques combining different sealers and filling methods.
1 treatment visit (in-person)
Duration - Minimum 6 months
Participants are monitored for clinical and radiographic success and healing after the root canal treatment.
At least 1 follow-up visit for evaluation
Trial Site Locations
Total: 1 location
1
Universidad Rey Juan Carlos
Madrid, Spain, Spain, 28922
Actively Recruiting
Research Team
G
Giulia Malvicini, DDS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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