Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
ID07019298

Evaluation of the Success Rate of Endodontic Treatment Using Different Obturation Techniques and Root Canal Sealer Cements: A Randomized Controlled Trial

Led by University of Siena · Updated on 2025-06-13

270

Participants Needed

1

Research Sites

178 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This research aims to compare the success of root canal treatments using two different sealers, AH Plus and NeoSealer Flo, along with two obturation techniques: continuous wave and single cone. The study involves 270 patients with conditions such as pulpal necrosis, irreversible pulpitis, and various periapical pathologies. It focuses on evaluating healing and quality of treatment over at least six months to understand the effectiveness of bioceramic sealer regardless of technique used. Participants will receive root canal filling using one of four combinations: AH Plus with continuous wave condensation, AH Plus with single cone, NeoSealer Flo with continuous wave, or NeoSealer Flo with single cone. AH Plus is a resin-based sealer, while NeoSealer Flo is a bioceramic, calcium silicate-based sealer. The continuous wave method uses heated gutta-percha to fill the canal densely, whereas the single cone technique uses a single cone and a high-flow sealer for simpler application. During the study, clinical and radiographic assessments will be made, including evaluating obturation quality, lesion healing, and restorations. The main measure is radiographic success based on Periapical Index criteria at a minimum of six months after treatment. Secondary measures include clinical symptom absence and CBCT imaging outcomes. Patient follow-up and adherence to evaluation schedules are important to monitor treatment success, with participation lasting at least six months post-treatment.

CONDITIONS

Brief Title

Success of Endodontic Treatment With Different Obturation Techniques and Sealer Cements

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients aged 18 years and older
  • Teeth diagnosed with pulpal necrosis or irreversible pulpitis
  • Provided informed consent for data usage
Not Eligible

You will not qualify if you...

  • Patients with systemic conditions that may impair healing (e.g., uncontrolled diabetes, immunosuppression)
  • Teeth with root fractures, resorption, or open apices
  • Incomplete clinical or radiographic records
  • Poor-quality or non-standardized radiographs for evaluation

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - Single session on treatment day

Participants receive root canal treatment using one of four obturation techniques combining different sealers and filling methods.

1 treatment visit (in-person)

Follow-up

Duration - Minimum 6 months

Participants are monitored for clinical and radiographic success and healing after the root canal treatment.

At least 1 follow-up visit for evaluation

Trial Site Locations

Total: 1 location

1

Universidad Rey Juan Carlos

Madrid, Spain, Spain, 28922

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Research Team

G

Giulia Malvicini, DDS

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

4

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