Actively Recruiting
SUCCESS Score Validation in Fuchs Dystrophy
Led by Instituto Ramón y Cajal de Investigación Sanitaria · Updated on 2025-12-04
250
Participants Needed
1
Research Sites
339 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This prospective multicenter diagnostic study aims to externally validate and extend the SUCCESS Score for predicting the need for endothelial keratoplasty after cataract surgery in patients with Fuchs endothelial corneal dystrophy (FECD). The model's performance and clinical utility are assessed using discrimination, calibration, and reclassification metrics.
CONDITIONS
Official Title
SUCCESS Score Validation in Fuchs Dystrophy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 60 years.
- Clinical diagnosis of Fuchs endothelial corneal dystrophy (FECD) grade 62 on the modified Krachmer scale.
- Presence of visually significant cataract requiring phacoemulsification surgery.
- Ability to provide informed consent and comply with study procedures.
- Availability of preoperative Scheimpflug tomography and corneal densitometry measurements.
You will not qualify if you...
- Epithelial or stromal edema precluding reliable corneal imaging.
- Previous ocular surgery (including corneal or intraocular procedures).
- Corneal trauma, infection, or inflammation affecting endothelial integrity.
- Coexisting ocular pathologies that could confound postoperative assessment (e.g., advanced glaucoma, macular degeneration).
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hospital Universitario Ramón y Cajal, Universidad de Alcalá, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)
Madrid, Madrid, Spain, 28034
Actively Recruiting
Research Team
F
Francisco Arnalich-Montiel, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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