Actively Recruiting
Sudden Cardiac Arrest Related to Sport in Young and Value of the Genetic Assessment: a French Prospective Register
Led by Rennes University Hospital · Updated on 2025-01-08
80
Participants Needed
26
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating sudden cardiac arrest (SCA) and sudden cardiac death (SCD) related to sports in young people aged 12 to 35 years. This study focuses on understanding the causes of these events, especially when no cause is found after standard medical checks. The aim is to improve prevention for affected families by combining medical autopsies, genetic testing, and toxicological analysis in a national, prospective registry. The study highlights the importance of identifying genetic heart diseases and other causes in this population to reduce unexplained cases and help families understand these tragic events. The study observes two groups: those who survived a sport-related sudden cardiac arrest (resuscitated SCA group) and those who did not survive (non-resuscitated SCD group). All cases undergo thorough evaluation including autopsy for deceased victims, whole exome sequencing for genetic mutations in survivors, and toxicological testing. If a genetic cause is found, family members may be offered genetic screening and appropriate medical care. The study does not compare treatments but collects detailed data from both groups to better understand the causes. Participants and their families will provide information for this observational study, which includes medical and genetic assessments, autopsies when applicable, and toxicology tests. Researchers will track the identification of causes through these combined methods over roughly three years. They will also evaluate how genetic and toxicological analyses contribute to diagnosis. The study aims to provide answers to families, offer preventive care to relatives when needed, and improve screening and prevention strategies for sports-related cardiac events.
CONDITIONS
Brief Title
Sudden Cardiac Arrest Related to Sport in Young and Value of the Genetic Assessment: a French Prospective Register
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Victims of sudden cardiac arrest aged 12 to 35 years
- No known cardiovascular disease
- Sudden and non-traumatic cardiac arrest during or within one hour of sports activity (leisure, training, or competition)
- For resuscitated victims, no opposition to participation by the individual or legal representative
- For non-resuscitated victims, no formal objection to reuse of medical data
- First-degree relatives without opposition to participation by themselves or their legal representatives
You will not qualify if you...
- Individuals weighing less than 20 kg if resuscitated from sudden cardiac arrest
- Victims or legal representatives under legal protection or deprived of liberty
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 3 to 6 months after the event
Participants undergo medical autopsy if deceased or clinical assessment if resuscitated, alongside genetic and toxicological analyses to identify the cause of sports-related sudden cardiac arrest.
1 to 2 visits depending on participant status
Duration - 3 to 30 months after the event
Participants and their first-degree relatives receive follow-up evaluations to assess familial transmission of hereditary cardiovascular pathologies and conduct whole exome sequencing if applicable.
Periodic visits over up to 30 months
Trial Site Locations
Total: 26 locations
1
APHP Hôpital Bichat
Paris, France, France, 75877
Not Yet Recruiting
2
APHP Hôpital Européen Georges Pompidou
Paris, France, France, 75908
Not Yet Recruiting
3
CHU Rennes
Rennes, France, France, 35000
Actively Recruiting
4
CHRU Besançon
Besançon, France, 25030
Not Yet Recruiting
5
CHU Bordeaux
Bordeaux, France, 33600
Not Yet Recruiting
6
CHU Brest
Brest, France, 29609
Not Yet Recruiting
7
CHU Caen
Caen, France, 14033
Not Yet Recruiting
8
CHU Clermont-Ferrand
Clermont-Ferrand, France, 63003
Not Yet Recruiting
9
APHP Hôpital Henri-Mondor
Créteil, France, 94010
Not Yet Recruiting
10
CHU Dijon Bourgogne
Dijon, France, 21079
Not Yet Recruiting
11
CHU de Grenoble Alpes
Grenoble, France, 38700
Not Yet Recruiting
12
CHRU Lille
Lille, France, 59037
Not Yet Recruiting
13
Hospices Civils de Lyon
Lyon, France, 69229
Not Yet Recruiting
14
APHM Hôpitaux universitaires de Marseille
Marseille, France, 13364
Not Yet Recruiting
15
CHRU Montpellier
Montpellier, France, 34295
Not Yet Recruiting
16
CHRU Nancy
Nancy, France, 54035
Not Yet Recruiting
17
CHU Nantes
Nantes, France, 44093
Not Yet Recruiting
18
CHU de Nice
Nice, France, 06003
Actively Recruiting
19
APHP Hôpital Pitié-Salpêtrière
Paris, France, 75651
Not Yet Recruiting
20
CHU Poitiers
Poitiers, France, 86000
Not Yet Recruiting
21
CHU Reims
Reims, France, 51092
Not Yet Recruiting
22
CHU Rouen
Rouen, France, 76031
Not Yet Recruiting
23
CHU Saint-Etienne
Saint-Etienne, France, 42100
Not Yet Recruiting
24
CHRU Strasbourg
Strasbourg, France, 67091
Not Yet Recruiting
25
CHU Toulouse
Toulouse, France, 31059
Not Yet Recruiting
26
CHRU Tours
Tours, France, 37044
Actively Recruiting
Research Team
F
Frédéric SCHNELL
S
Stéphanie Jolly
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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