French National Study on Sudden Cardiac Arrest and Death Related to Sports in Young People Aged 12 to 35 with Genetic Testing

What this Trial Is About

Researchers are investigating sudden cardiac arrest SCA and sudden cardiac death SCD related to sports in young people aged 12 to 35 years. This study focuses on understanding the causes of these events, especially when no cause is found after standard medical checks. The aim is to improve prevention for affected families by combining medical autopsies, genetic testing, and toxicological analysis in a national, prospective registry. The study highlights the importance of identifying genetic heart diseases and other causes in this population to reduce unexplained cases and help families understand these tragic events. The study observes two groups those who survived a sport-related sudden cardiac arrest resuscitated SCA group and those who did not survive non-resuscitated SCD group. All cases undergo thorough evaluation including autopsy for deceased victims, whole exome sequencing for genetic mutations in survivors, and toxicological testing. If a genetic cause is found, family members may be offered genetic screening and appropriate medical care. The study does not compare treatments but collects detailed data from both groups to better understand the causes. Participants and their families will provide information for this observational study, which includes medical and genetic assessments, autopsies when applicable, and toxicology tests. Researchers will track the identification of causes through these combined methods over roughly three years. They will also evaluate how genetic and toxicological analyses contribute to diagnosis. The study aims to provide answers to families, offer preventive care to relatives when needed, and improve screening and prevention strategies for sports-related cardiac events.

Sudden Cardiac Arrest Related to Sport in Young and Value of the Genetic Assessment: a French Prospective Register