Actively Recruiting
Sufentanil Infusion vs Intravenous Methadone for Postoperative Analgesia Following Head and Neck Dissection With Free Flap or Rotational Reconstruction
Led by Indiana University · Updated on 2026-05-01
128
Participants Needed
1
Research Sites
146 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main purpose of this study is to determine which type of medication, sufentanil or methadone, is better at controlling pain during and, more importantly, after surgery in patients undergoing a head and neck dissection with free flap or rotational tissue reconstruction. Prior to their operation, subjects will be randomized to receive either Sufentanil or Methadone. After surgery, research staff will obtain information about recovery and pain levels.
CONDITIONS
Official Title
Sufentanil Infusion vs Intravenous Methadone for Postoperative Analgesia Following Head and Neck Dissection With Free Flap or Rotational Reconstruction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing head and neck dissection with free flap or rotational reconstruction at Indiana University Health Adult Academic Health Center
- ASA class 1, 2, or 3
- Age between 18 and 80 years
- Male or female
- Able and willing to provide written informed consent
You will not qualify if you...
- Any contraindication to opiates, including allergy to opioids or substance use disorder
- Currently on home methadone at any dose
- Physical, mental, or medical conditions that may affect measuring postoperative pain
- Known true allergy to sufentanil or methadone
- History of substance abuse in the past 6 months, including heroin or illegal drugs
- End stage liver disease or end stage renal disease
- Patient remaining intubated or on mechanical ventilation after surgery
- Taking more than 30 mg oral morphine equivalent per day at home
- Undergoing additional or concurrent surgical procedures
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Indiana University
Indianapolis, Indiana, United States, 46202
Actively Recruiting
Research Team
L
Lyla S Farlow
CONTACT
A
Angie M Plummer
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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