Actively Recruiting
Sun Yat-Sen Prospective Cohort Study of Central Nervous System Idiopathic Inflammatory Demyelinating Diseases
Led by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Updated on 2024-08-07
450
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to understand the causes and clinical outcomes of central nervous system idiopathic inflammatory demyelinating diseases (CNS IIDD) in the Chinese population. It focuses on clarifying the clinical features and factors that affect prognosis for diseases like multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), and others. The study also investigates how biomarkers relate to disease occurrence, progression, and prognosis to help guide clinical treatment decisions. Participants are diagnosed according to established criteria such as the 2017 McDonald criteria for MS, the 2015 IPND diagnostic panel for NMOSD, and other international expert panel standards for related disorders. They receive diagnosis and treatment plans based on current international and national guidelines or expert consensus, without any additional special interventions. The study groups include those with MS, NMOSD, MOGAD, acute disseminated encephalomyelitis (ADEM), clinically isolated syndrome (CIS), or undefined CNS IIDD. Treatment and clinical management follow recommended practices from diagnosis onward. During participation, patients undergo clinical evaluations, follow-up visits, and management by neuroimmunology specialists. Researchers monitor outcomes such as disease relapse and long-term neurological function over an average of five years. Assessments include neurological function scales, optical coherence tomography of the eyes, immune marker changes, antibody levels, and various evoked potential tests at baseline and regular intervals up to three years. The study aims to provide comprehensive data on disease progression and prognosis with continuous monitoring and follow-up care.
CONDITIONS
Brief Title
Sun Yat-Sen Cohort of CNS Idiopathic Inflammatory Demyelinating Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18-65 years with central nervous system idiopathic inflammatory demyelinating diseases (CNS IIDD)
- Clinical syndrome of the attack meets one of the following: MS, NMOSD, MOGAD, ADEM, clinically isolated syndrome, demyelinating encephalopathy, demyelinating myelitis, or brainstem encephalitis
- Agree to participate in this study and sign the informed consent form
You will not qualify if you...
- History of tumors or diagnosis of central nervous system tumors
- Infectious lesions of the central nervous system
- Hereditary, metabolic, toxic, vascular, or traumatic demyelinating diseases of the brain or spinal cord
- Non-compliance with treatment and follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Average of 5 years
Participants are observed over several years to monitor relapses and assess long-term neurological function through regular assessments.
Assessments at baseline, 6 months, 1 year, 2 years, and approximately 3 years
Trial Site Locations
Total: 1 location
1
Sun Yat-sen Memorial Hospital
Guangzhou, Guangdong, China, 510120
Actively Recruiting
Research Team
H
Hongxuan Wang
W
Wanru Chen
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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