Actively Recruiting
Superior Hypogastric Plexus Block for Early Recovery After Laparoscopic Colorectal Cancer Surgery: A Randomized Controlled Trial
Led by Sixth Affiliated Hospital, Sun Yat-sen University · Updated on 2026-05-12
170
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of a superior hypogastric plexus block (SHPB) to improve early recovery quality after laparoscopic colorectal cancer surgery. This single-center, randomized, double-blind, placebo-controlled trial will enroll 170 patients to compare SHPB with a placebo block. The study aims to clarify the role of SHPB within the Enhanced Recovery After Surgery (ERAS) strategy for this type of surgery. Participants will be randomly assigned to receive either a SHPB containing 20 mL of 0.75% ropivacaine hydrochloride or a placebo block with 20 mL of 0.9% normal saline after pneumoperitoneum is established during surgery. The injection is performed by tenting the presacral peritoneum and using a laparoscopic needle-tip syringe for precise delivery. This intervention occurs during laparoscopic colorectal cancer surgery, with patients monitored closely afterward. During the study, researchers will assess the quality of recovery using the 15-item Quality of Recovery (QoR-15) score at 24 hours after surgery. They will also evaluate pain scores at rest and during movement, morphine use, time to first bowel movement, incidence of postoperative ileus, length of hospital stay, and inflammation markers such as interleukin-6 and C-reactive protein. Secondary measures include pain inventories and questionnaires up to 90 days after surgery. Safety and recovery progress will be tracked throughout the hospital stay and up to three months post-surgery.
CONDITIONS
Brief Title
Superior HypogastrIc plExus bLock During Laparoscopic Colorectal Cancer Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to provide informed consent
- Undergoing elective laparoscopic radical resection for colorectal cancer
- American Society of Anesthesiologists Physical Status (ASA) class I-III
You will not qualify if you...
- Allergy to block medication(s)
- Coagulation dysfunction
- Local or systemic infection
- Unable to cooperate with the completion of the study protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Surgery day and up to 2 postoperative days
Participants undergo laparoscopic colorectal cancer surgery with either a superior hypogastric plexus block containing ropivacaine or a placebo block containing saline to improve postoperative recovery.
1 surgery visit and daily visits for up to 2 days postoperatively
Duration - Up to 3 months after surgery
Participants are assessed for pain, recovery quality, and hospital stay length up to 3 months after surgery.
Visits up to postoperative day 90 including assessments for pain and recovery
Trial Site Locations
Total: 1 location
1
The Sixth Affiliated Hospital of Sun Yet-set University
Guangzhou, Guangdong, China, 510000
Actively Recruiting
Research Team
M
Mengying Ding
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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