Actively Recruiting
Superiority of On-demand PrEP Versus PEP on Using Doxycycline for Preventing STI in MSM
Led by Chinese University of Hong Kong · Updated on 2025-04-04
300
Participants Needed
1
Research Sites
191 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to compare the effectiveness of doxycycline taken for on-demand pre-exposure prophylaxis (DoxyODPrEP) and its post-exposure use (DoxyPEP) in preventing bacterial sexually transmitted infections (STI), including chlamydia, gonorrhoea, and syphilis among men who have sex with men (MSM). The main questions it aims to answer are: 1. Is DoxyODPrEP superior to DoxyPEP? 2. Are both regimens safe? 3. Does the MSM community accept the use of doxycycline to prevent bacterial STI? Participants will be asked to take doxycycline according to the study arm they are randomly assigned to, and attend regular clinical follow-ups during the 2-year observation period. Researchers will compare the bacterial STI incidences between the two groups to see if DoxyODPrEP is superior to DoxyPEP.
CONDITIONS
Official Title
Superiority of On-demand PrEP Versus PEP on Using Doxycycline for Preventing STI in MSM
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Has had sex with another male in the past six months
- Normally resides in Hong Kong
- Can communicate in written and spoken Chinese or English
- Willing and able to give written informed consent
- Willing and able to attend scheduled study clinic visits
- At risk of sexually transmitted infections (had condomless sex with more than one man in the past 12 months, history of STI diagnosis in the past 12 months, inclination to have condomless sex, or other HIV-PrEP-eligible criteria)
You will not qualify if you...
- Allergic to tetracycline class medicines
- Currently taking medications that are contraindicated with doxycycline
- Using antibiotics for more than 14 days in the month before enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Stanley Ho Centre for Emerging Infectious Diseases
Shatin, Hong Kong
Actively Recruiting
Research Team
S
Secretariat
CONTACT
T
Tsz Ho Kwan, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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