Actively Recruiting
Superselective Adrenal Arterial Embolization for Refractory Hypertension: A Proof-of-Concept Study
Led by Second Affiliated Hospital of Nanchang University · Updated on 2024-08-23
20
Participants Needed
1
Research Sites
173 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The subjects of this study were patients with essential refractory hypertension. The purpose of this study is to evaluate the safety and efficacy of superselective adrenal arterial embolization (SAAE) in patients with primary refractory hypertension and to explore the possibility of SAAE in patients with primary refractory hypertension.After the subject completes the SAAE, an 8-week follow-up will be conducted to assess the safety and effectiveness of the SAAE.
CONDITIONS
Official Title
Superselective Adrenal Arterial Embolization for Refractory Hypertension: A Proof-of-Concept Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years, any gender
- Primary refractory hypertension taking three antihypertensive drugs including a diuretic
- Average office systolic blood pressure 6150 mmHg measured three times
- Duration of hypertension longer than 6 months
- Standing plasma aldosterone and renin activity not below the unit's reference lower limit
- Signed informed consent form
You will not qualify if you...
- Morning cortisol level below 4.3 bcg/dL
- Estimated glomerular filtration rate (eGFR) below 45 mL/min/1.73 m8
- Serum potassium level above 5.5 mmol/L
- Type 1 diabetes, uncontrolled hyperthyroidism, malignant arrhythmias, malignant tumors
- Decompensated heart failure, severe liver dysfunction, severe hematologic diseases
- Severe obstructive sleep apnea syndrome
- History of myocardial infarction, syncope, cerebral hemorrhage, or cerebral infarction within 3 months
- Pregnancy or planning to conceive within the next year
- Severe organic diseases preventing tolerance of the procedure
- Adrenal mass larger than 2 cm in diameter
- Severe allergy to contrast agents
- Enrollment or planned participation in other clinical studies affecting this trial's results
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Second Affiliated Hospital of Nanchang University
Nanchang, China
Actively Recruiting
Research Team
Y
Yifei the second affiliated hospital of Nanchang university, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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