Actively Recruiting
Support Tool for Antibiotic Allergy deLabeling
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2025-12-16
3000
Participants Needed
1
Research Sites
59 weeks
Total Duration
On this page
Sponsors
U
Universitaire Ziekenhuizen KU Leuven
Lead Sponsor
N
Noorderhart Pelt
Collaborating Sponsor
AI-Summary
What this Trial Is About
Antibiotic allergy labels (AAL) are reported in 7% of inpatient's charts, especially for beta-lactams (86% of AAL, i.e., prevalence of 6%). They are associated with increased length of hospital stay, and use of second-line and broad-spectrum antibiotics. Allergy workups are able to invalidate the majority of these AAL but are time-consuming and require invasive skin and provocation testing. The investigators recently evaluated, for the first time in Europa, a strictly non-invasive delabeling protocol using a questionnaire, medical file search and contact with primary care health care workers in 200 adult internal medicine inpatients with a beta-lactam AAL. Up to half of the AAL could be removed or refined, demonstrating the potential of this strategy. In this project, they aim to assess the impact of using the non-invasive 'AAL-fact-check' tool in a multicenter study, on antibiotic selection, and clinical, antimicrobial, and economic endpoints, as compared with the standard of care (i.e., no AAL-fact-check tool).
CONDITIONS
Official Title
Support Tool for Antibiotic Allergy deLabeling
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hospitalized patients
- Have an antibiotic allergy label for one or more beta-lactam antibiotics
You will not qualify if you...
- Younger than 18 years old
- Previously enrolled in this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospitals Leuven
Leuven, Belgium
Actively Recruiting
Research Team
L
Liesbeth Gilissen, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
CROSSOVER
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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