Actively Recruiting
Supporting Treatment Access and Recovery in COD
Led by University of Massachusetts, Worcester · Updated on 2025-06-05
1000
Participants Needed
5
Research Sites
233 weeks
Total Duration
On this page
Sponsors
U
University of Massachusetts, Worcester
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This 4-year study will randomize 1,000 people with co-occurring opioid use and mental health disorders (COD) at medication for opioid use disorder (MOUD) clinics to evaluate the effectiveness of MISSION, a multi-component team approach, or its components with MOUD versus MOUD alone, as well as the incremental benefits of MISSION or its components for improving outcomes. We expect that individuals receiving MISSION or its parts + MOUD will show greater improvement over MOUD alone on: engagement, substance use, and mental health.
CONDITIONS
Official Title
Supporting Treatment Access and Recovery in COD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Are 18 years-old and older
- Are fluent in English or Spanish
- Have opioid use disorder and are either newly admitted to the program with OUD or have been active on medications like buprenorphine or naltrexone but experienced a recent relapse with any substance
- Able to provide consent
- May have a concurrent substance use disorder in addition to opioids
- Have a co-occurring mental health disorder including depression, anxiety, trauma-related disorders, bipolar disorder, or schizophrenia, or have worsening symptoms of these disorders even without relapse
You will not qualify if you...
- Are not fluent in English or Spanish
- Are acutely psychotic, acutely suicidal with a plan, or homicidal
- Are incompetent and unable to provide informed consent
- Have severe alcohol use disorder or high dose benzodiazepine use needing detoxification, including history of severe alcohol withdrawal or seizures
- High dose benzodiazepine use defined as Lorazepam > 10 mg/day, Diazepam > 100 mg/day, Clonazepam > 5 mg/day, or Alprazolam > 5 mg/day
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Behavioral Health Network
Holyoke, Massachusetts, United States, 01040
Actively Recruiting
2
Behavioral Health Network
Orange, Massachusetts, United States, 01364
Actively Recruiting
3
Behavioral Health Network
Springfield, Massachusetts, United States, 01104
Actively Recruiting
4
UMass Chan Road to Care Clinic
Worcester, Massachusetts, United States, 01601
Actively Recruiting
5
SaVida Health
Worcester, Massachusetts, United States, 01605
Actively Recruiting
Research Team
D
David Smelson, PsyD
CONTACT
A
Abigail Helm, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
5
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