Actively Recruiting
Supramaximal High-Intensity Interval Training in People With and Without Chronic Obstructive Pulmonary Disease
Led by Umeå University · Updated on 2024-05-23
208
Participants Needed
2
Research Sites
264 weeks
Total Duration
On this page
Sponsors
U
Umeå University
Lead Sponsor
H
Hasselt University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Beyond pulmonary complications, COPD presents with extrapulmonary manifestations including reduced cognitive, cardiovascular, and muscle function. While exercise training is the cornerstone in the non-pharmacological treatment of COPD, there is a need for new exercise training methods. The COPD-HIIT trial intend to investigate the effects and mechanisms of 12 weeks supramaximal high-intensity interval-training (HIIT) compared to moderate intensive continous training (MICT) in people with COPD and matched healthy controls on important clinical outcomes. The trial also intends to compare the effects of 24 months of exercise training (supramaximal HIIT or MICT) to usual care in people with COPD on brain health, cardiorespiratory fitness and muscle power; in people with COPD.
CONDITIONS
Official Title
Supramaximal High-Intensity Interval Training in People With and Without Chronic Obstructive Pulmonary Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 60 years of age or older
- Independent in activities of daily living
- For people with COPD: Symptomatic with COPD assessment test score 6 or modified Medical Research Council dyspnea scale score 2 or not regularly physically active at moderate or high intensity over the last year
- For people with COPD: Confirmed COPD diagnosis by post-bronchodilator spirometry with FEV1/FVC ratio < 0.70
- For healthy controls: Normal lung function
You will not qualify if you...
- Unstable movement-related, cardiovascular, neuromuscular, metabolic, skeletal, or rheumatic conditions that prevent exercise or tests
- Musculoskeletal pain that prevents exercise or testing
- Recent heart events such as myocardial infarction, bypass surgery, or angioplasty
- Uncontrolled high blood pressure
- Abnormal ECG findings during exercise test
- Other lung diseases like asthma, interstitial lung disease, lung cancer, pulmonary hypertension, or pulmonary fibrosis
- Medical conditions or treatments affecting brain function or cognition, including head trauma, neurological diseases, severe cognitive impairment, recent or current cancer treatment
- MRI or PET/CT contraindications such as metal implants or claustrophobia
- Inability to read or speak Swedish (Ume� University participants), Dutch or French (Hasselt University participants), or English
- For COPD patients: Co-morbidities limiting exercise more than COPD
- Currently or recently (past 12 months) in pulmonary rehabilitation
- Recent COPD exacerbation requiring medication change within six weeks
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Hasselt University
Hasselt, Diepenbeek, Belgium, 3590
Actively Recruiting
2
Umeå University
Umeå, Sweden
Actively Recruiting
Research Team
A
André Nyberg, PhD
CONTACT
J
Johan Jakobsson, M.Sc.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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