Actively Recruiting
Supraspinal Processing of Sensory Aspects of Pain
Led by Children's Hospital Medical Center, Cincinnati · Updated on 2025-07-01
350
Participants Needed
1
Research Sites
217 weeks
Total Duration
On this page
Sponsors
C
Children's Hospital Medical Center, Cincinnati
Lead Sponsor
U
University of Barcelona
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this basic science study is to learn about the brain mechanisms of chronic pain across different chronic pain syndromes in pediatric patients. The main questions it aims to answer are: * Are there shared and distinct brain systems engaged by different forms of pediatric chronic pain? * What are predictors of recovery from chronic pain? * What brain systems are associated with the spread of pain? For this study participants will undergo: * Functional Magnetic Resonance Imaging (fMRI) * Quantitative Sensory Testing * Psychological Assessments
CONDITIONS
Official Title
Supraspinal Processing of Sensory Aspects of Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of chronic pain consistent with ICD-11 criteria for headache (migraine, daily headache), abdominal pain (FAPD), localized musculoskeletal pain, diffuse musculoskeletal pain, or complex regional pain syndrome
- Stable doses of prescribed pain and/or psychiatric medications for at least 4 weeks prior to baseline visit
- Male or female aged 10 to 17 years inclusive
- English speaking and able to complete interviews and questionnaires in English
You will not qualify if you...
- Weight or size incompatible with MRI scanner
- Presence of orthodontic braces, metallic or electronic implants, or other metal objects interfering with MRI safety or imaging
- Claustrophobia
- Pregnancy in youth
- Comorbid rheumatic disease, epilepsy, other neurological diseases, or medical conditions such as diabetes, cancer, or inflammatory bowel disease
- Present psychiatric disorders defined by DSM IV (e.g., psychosis, bipolar disorder, major depression, generalized anxiety disorder), alcohol or drug dependence, or developmental delays/impairments that interfere with study participation
- Skin conditions or past skin damage near sensory testing sites on arms or legs
- Age outside 10 to 17 years at time of consent
- History of opioid treatment longer than 1 month
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Cincinnati Children's Hospital
Cincinnati, Ohio, United States, 45229
Actively Recruiting
Research Team
C
Catherine Jackson, MSc
CONTACT
H
Hannah Schildmeyer, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
5
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