Study of Surgery, Tumor Modeling, and Genomic Analysis in Gastrointestinal Stromal Tumors GISTs

What this Trial Is About

Researchers are following people with gastrointestinal stromal tumors GISTs, including wild-type WT and treatment-resistant types, to support research and improve understanding of this rare disease. GISTs often have mutations making them responsive to certain therapies, but some types resist these treatments. The study aims to evaluate patients over time, especially focusing on disease-free intervals after surgery. Participants will be monitored regularly every 6 to 12 months for up to 10 years before surgery, and if surgery is needed, it will be performed at the NIH Clinical Center. After surgery, participants will continue to be monitored every 6 to 12 months for up to 5 years. Tumor tissue samples will be collected during surgery for research purposes to help develop models and identify new treatment targets. During the study, participants will have medical history reviews, physical exams, and assessments of daily function. They may have genetic counseling and testing, blood samples, cheek swabs, and imaging scans like CT or MRI. Monitoring will continue based on surgery status, with the goal of understanding disease progression and supporting treatment research. Total participation may last up to 15 years depending on surgeries and follow-up.

Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis