Actively Recruiting
Surgical Site Infections and the Microbiome: Understanding the Pathogenesis of Surgical Site Infections
Led by University of Minnesota · Updated on 2026-05-08
300
Participants Needed
1
Research Sites
117 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective, observational study of patients undergoing open GI surgery. At the time of operation, samples will be collected from the incision site and GI tract. The study will follow patients up to 30 days postoperatively, monitoring for signs of SSI. Samples will be taken from all patients who develop SSI. Sequencing will be performed on a subset of samples based on our specific aims. * Aim 1: conduct a case-control study of patients with SSI and age-, sex-, diagnosis-, and wound class-matched control patients without SSI, comparing microbiome alpha diversity and community composition with 16S RNA sequencing to determine the association with SSI. * Aim 2: identify the strain of bacteria isolated from SSIs using shotgun metagenomic sequencing and determine whether the specific strain was present in the skin and gut at the time of operation.
CONDITIONS
Official Title
Surgical Site Infections and the Microbiome: Understanding the Pathogenesis of Surgical Site Infections
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients aged 18 years or older
- Undergoing open abdominal surgery during the study period
- Surgery includes entry into the peritoneal cavity through a midline incision with a skin incision 5cm or greater
You will not qualify if you...
- Patients scheduled for minimally invasive surgery such as laparoscopic or robotic surgery
- Patients who have surgery converted from laparoscopic or robotic to open surgery
- Patients undergoing appendectomy or cholecystectomy
- Patients having vascular, gynecological, obstetric, urological, or transplantation surgery
- Trauma patients
- Patients without source control at the initial surgery, including those with open abdomen, no fascial closure, or temporary abdominal closure device
- Pediatric patients younger than 18 years
- Patients who decline swab or specimen collection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Minnesota
Minneapolis, Minnesota, United States, 55414
Actively Recruiting
Research Team
K
Kathryn Vera
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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