Comparing Surgical Treatment of Peri-implantitis With and Without Platelet Rich Fibrin PRF A 12-Month Randomized Study

What this Trial Is About

Researchers are evaluating the use of platelet-rich fibrin PRF, a natural blood-derived product rich in growth factors, to enhance healing and bone regeneration in peri-implantitis, a chronic infection causing inflammation and bone loss around dental implants. This study aims to compare surgical cleaning of peri-implantitis defects combined with PRF application to surgical cleaning alone, assessing improvements in tissue regeneration and healing. The trial is randomized and evaluates outcomes over 12 months using clinical and radiographic measures. The study involves two groups one receiving open flap debridement with a chemo-electric device plus PRF clots and membranes applied into the defect, and the other receiving the same debridement and detoxification without PRF. Blood is drawn for PRF preparation in the treatment group, and after surgical cleaning, the flap is closed in both groups. Implants with similar defect sizes are randomly assigned to either group for comparison. Participants will undergo clinical evaluations including radiographic defect fill, probing pocket depth, bleeding on probing, and soft tissue healing indices at baseline and after 12 months. Patient-reported pain is also measured using a visual analog scale shortly after surgery. The study includes monitoring of keratinized tissue width and composite clinical indices to assess treatment effects. The total participation period includes follow-ups at multiple time points within one year post-surgery.

Surgical Treatment of Peri-implantitis With Adjunctive Application of Platelet Rich Fibrin (PRF)