Comparing Surgery and Percutaneous Procedures for Patients with Reduced Heart Function and Multivessel Coronary Artery Disease

What this Trial Is About

Researchers are evaluating coronary artery bypass grafting CABG versus percutaneous coronary intervention PCI in patients with ischemic left ventricular systolic dysfunction LVEF less than 40% and multivessel coronary artery disease. This randomized multicenter trial involves 358 patients and aims to compare survival, major cardiovascular events, and quality of life over 4 years. The study also contributes to the international STICH 3.0 collaboration for long-term outcome analysis. Participants will be randomly assigned to receive either CABG or PCI, both aiming for full revascularization of the affected coronary vessels. CABG is a surgical procedure, while PCI is a less invasive percutaneous procedure. The study is open-label and controlled, conducted at multiple centers, ensuring careful evaluation of each treatment method in appropriate candidates. During the 4-year follow-up, researchers will measure a composite outcome including all-cause mortality, major adverse cardiovascular events, and heart failure hospitalizations. Quality of life will be assessed at 1 and 4 years using the Kansas City Cardiomyopathy Questionnaire and the Seattle Angina Questionnaire. Additional outcomes include cardiovascular mortality, procedural myocardial infarction, revascularization rates, and cost-effectiveness. Participants will be monitored closely for safety and clinical status throughout the study.

Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function (STICH 3.0-NL)