Actively Recruiting
Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function (STICH 3.0-NL)
Led by University Medical Center Groningen · Updated on 2026-05-12
358
Participants Needed
1
Research Sites
417 weeks
Total Duration
On this page
Sponsors
U
University Medical Center Groningen
Lead Sponsor
D
Dutch Heart Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This randomized multicenter trial compares coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) in 358 patients with ischemic left ventricular dysfunction and multivessel coronary disease. The study evaluates differences in survival, major cardiovascular events, and quality of life over 4 years, and contributes to the international STICH 3.0 collaboration assessing long-term outcomes.
CONDITIONS
Official Title
Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function (STICH 3.0-NL)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Left ventricular ejection fraction 40% or less
- Angina pectoris with Canadian Cardiovascular Society class 2 or higher and/or hospitalization for acute coronary syndrome or heart failure within 1 year before randomization
- Multivessel coronary artery disease with 2-3 vessel disease including lesions over 70% and involvement of proximal left anterior descending artery and/or left main stenosis over 50%
- Suitable clinical and angiographical features for isolated coronary revascularization by CABG or PCI as judged by the local Heart Team
- Written informed consent given
You will not qualify if you...
- Acute coronary syndrome less than 48 hours before randomization
- Valvular or structural heart disease requiring intervention
- Contraindications to dual antiplatelet therapy
- Non-cardiac condition with life expectancy less than 1 year
- Previous coronary artery bypass grafting
- Decompensated heart failure at the time of inclusion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Medical Center Groningen
Groningen, Netherlands
Actively Recruiting
Research Team
E
Erik Lipsic, Dr
CONTACT
R
Ruben R. De With, Dr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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